Title: Effect of FK506 on peripheral nerve collateral generation
Abstract: Objective To study the effect of FK506 on peripheral nerve collateral generation after end-to-side anastomosis.Methods In 26 Wistar rats,peroneal nerve was transacted on the right side of all the animals.The proximal end of peroneal nerve was turned back and ligated,and the distal end was sutured to the side of tibial nerve with perineurial window.No operation was done on the left side.The animals were divided into two groups(each group having 13 animals).FK506 was injected into the right tibial muscle(2mg/kg/d),once a day within 2 weeks in the experimental group,and saline was used in control group.Three months after operation,the peroneal nerve and the tibial muscle were taken out for histological exmination,and the muscle wet weight was examed.Results Peroneal nerve regenerated in both groups.In constrast,there was significant difference between the two groups in the number of regen- erated nerve fiber,the muscle wet weight,the muscle fiber cross sectional area,and the motet endplate area and color.Conclusion FK506 can promote peripheral nerve collateral generation in end-to-side anastomosis.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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