Title: Study of the effect of end to side coaptation on rat common peroneal nerve by HRP tracing method
Abstract: Objective To compare the effect of end to side coaptation with that of end to end
coaptation on peripheral nerve regeneration in rats,by means of horseradish peroxidase(HRP)
tracing. Methods 36 Wistar rats were randomly divided into three groups after the right
common peroneal nerve was transected. In group A,the distal end of the right common peroneal
nerve was sutured to the side of the tibial nerve through a perineurial window. In group B, the
distal end of the right common peroneal nerve was sutured to the proximal end.No
neurorrhaphy of the common peroneal nerve was performed in group C (control group). 0.1 l of
30 % HRP was injected into the trunk of the right common peroneal nerve distal to the suture
site. 72 hours later, the rats were sacrificed to harvest the spinal cord segment and the dorsal
root ganglion of T12 to L6 segments for histological study. Results Positive HRP marked cells
were found in the spinal ganglion, the posterior horn and the anterior horn of the spinal cord on
the twelfth postoperative week in group A. Compared with those in group B, postive HRP marked
cells in group A appeared 6 weeks later, and the number was 45.7 % fewer. No positive HRP
marked cells was found in group C. ConclusionsPeripheral nerve regeneration could be
achieved after end to side coaptation, but was inferior to that obtained after end to end
coaptation.
Publication Year: 1999
Publication Date: 1999-01-01
Language: en
Type: article
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