Title: Clinical Significance of Urinary Monocyte Chemoattractant Protein-1 and Serum Cystatin C in the Early Diagnosis of Diabetic Nephropathy
Abstract: Objective To explore the clinical significance of urinary monocyte chemoattractant protein-1(UMCP-1) and serum cystatin C(CysC)in the early diagnosis of diabetic nephropathy.Methods Based on urinary albumin excretion rate(UAER),137 patients with type 2 diabetes were divided into three groups:diabetic nephropathy group(clinical group,46 cases),early group of diabetic nephropathy(early group,48 cases),and pre-diabetic nephropathy group(pre-stage group,43 cases).Fifty healthy subjects were enrolled as controls.UMCP-1[in the form of UMCP-1/urinary creatinine(UMCP-1/UCr)],serum CysC,microalbuminuria(UMA) and serum creatinine(SCr) concentrations were detected in all groups.Results Levels of UMCP-1 and serum CysC were significantly higher in the pre-stage group than in the control group(P0.05).Levels of UMCP-1,serum CysC and UMA were higher in the early group and the clinical group than in the pre-stage group and the control group(P0.01).Relation analysis revealed that both UMCP-1/UCr and CysC were positively correlated with UMA(P0.05).Conclusion The combination of urinary UMCP-1 and serum CysC detection is helpful to the early diagnosis of diabetic nephropathy.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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