Title: Clinical significance of measurement of serum uric acid and high sensitivity C-reactive protein in patients with coronary heart disease
Abstract: Objective:To observe changes and clinical significance of levels of serum uric acid(UA) and high sensitivity C-reactive protein(hs-CRP) in patients with coronary heart disease(CHD).Methods:According to result of coronary angiography,96 CHD patients were divided into single-vessel coronary disease group(n=30),double-vessel coronary disease group(n=50) and triple-vessel coronary disease group(n=16).Levels of UA and hs-CRP of patients were measured and compared with those of 42 persons with normal coronary angiography(normal control group).Results:Compared with normal control group,UA level(329.81±42.25) mmol/L,hs-CRP level(2.69±0.81) mg/L significantly increased in CHD group(P0.001 all).As degree of coronary disease increased(single-vessel,double-vessel,triple-vessel coronary disease),its levels of UA and hs-CRP increased,UA respectively was:(359.97±32.09) mmol/L vs.(383.32±39.31) mmol/L vs.(420.81±36.47) mmol/L,hs-CRP respectively was:(4.06±1.02) mg/L vs.(6.36±0.78) mg/L vs.(8.10±0.64) mg/L,P0.05~0.001.Levels of UA and hs-CRP were positively correlated with histopathologic scores(r=0.857,P0.001;r=0.915,P0.05).Conclusion:Levels of uric acid and high sensitivity C-reactive protein are positively correlated with coronary heart disease and they are risk factors for coronary heart disease.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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