Title: Effect of Electroacupuncture on Synaptic Transmission in Hippocampal Dentate Gyrus of Rats with Cerebral Ischemic Damage
Abstract: [ Objective ] To investigate the effect of electroacupuncture ( EA) on synaptic transmission in hippocampal dentate gyrus of rats with cerebral ischemic damage. [Methods] Sixty Wistar rats were enrolled into this study. Among them, 30 were given high-frequency stimulation (HFS) and the other 30 were not. Then the HFS rats were randomized into sham-operation group (group A), model group (group B) and acupuncture group (group C); so did the non-HFS rats. Bilateral carotid arteries were exposed but not blocked in Group A, while were blocked by traction with silk thread for modeling in group B. Group C were treated with EA before and after modeling. Effects of EA on synaptic transmission in hippocampal dentate gyrus of non-HFS rats were evaluated with in-vivo long-term potential ( LTP) recorded by electrophysiological technique. Effects of EA on LTP in hippocampal dentate gyrus of HFS rats were observed after LTP was induced by HFS. [Results] In non-HFS rats, no significant changes of magnitude of population spike (PS) occurred within 120 min in group A; magnitude of PS in group B decreased at 10th min after modeling ( P 0.01 compared with group A) and then ascended to that of group A; magnitude of PS in group C showed no obvious decrease at 10th min after modeling but began to increase after 10 min ( P 0.05 or P 0.01 compared with group B). In HFS rats, magnitude of PS increased and maintained high level for 3 hours in group A after the occurrence of LTP induced by HFS; LTP occurred in group B 30 min after HFS; given EA 30 min after HFS, magnitude of PS in group C began to increase at 60 min after HFS, and it differed from that of group B at 120th min and 180th min after HFS ( P 0.05 or P 0.01) . [Conclusion] EA promotes the synaptic transmission in hippocampal dentate gyrus of non-HFS rats and increases LTP after HFS, which may be one of the therapeutic mechanisms of EA for cerebral ischemia.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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Cited By Count: 1
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