Title: Effect of Electroacupuncture on Hippocampal Neurogenesis in Epilepsy Rats
Abstract: Objective: To observe the possible effect of hippocampal neurogenesis on electroacupuncture (EA) in treating epilepsy rats. Methods: Epilepsy rats models were induced with lithium chloride-pilocarpine. The frequency of spontaneous recurrent seizures (SRS) was observed after EA for 1,3 and 4 week(s). Immunohistochemical assay was used to detect the number of neoformative neurons with 5-bromo-2-deoxyuridine (Brdu) positive in hippocampal dentate gyrus. Results: Earliest SRS occurred in the survival rats at epileptic state 3 days after the onset of epilepsy. From the second week,SRS was found in the model group and EA group. After EA for 3 and 4 weeks,the frequency of SRS was reduced in EA group ( P 0. 05 compared with the model group).The number of Brdu-positive neurons was increased in the model group one week and 3 weeks after the onset of epilepsy( P 0. 01 compared with the blank group),and decreased to the level of blank group from the fourth week. On the first week of EA,the number of Brdu-positive neurons was decreased,but the difference was insignificant as compared with the model group ( P 0. 05 ),and then the decrease was obvious on the third week ( P 0. 05).The number of Brdu-positive neurons in EA group arrived to the level in the model group and blank group on the fourth week of EA. Conclusion: EA can inhibit the hippocampal neurogenesis in the hippocampal dentate gyrus of epilepsy rats,indicating that hippocampal neurogenesis plays an important role in the therapeutic effect of EA.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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