Title: Detection value of anti-cyclic citrullinated peptide antibody in early diagnosis in patients with rheumatoid arthritis
Abstract:Objective The sensitivity and specificity of anti-cyclic citrullinated peptide antibody(anti-CCP)and rheumatoid factor(RF)in patients with rheumatoid arthritis(RA)was evaluated,and to observe the ther...Objective The sensitivity and specificity of anti-cyclic citrullinated peptide antibody(anti-CCP)and rheumatoid factor(RF)in patients with rheumatoid arthritis(RA)was evaluated,and to observe the therapeutic effect of MTX on anti-CCP antibody positive early RA.Methods Elisa was used to evaluate the sensitivity and specificity of anti-cyclic citrullinated peptide antibody(anti-CCP),and rheumatoid factor(RF)in patients with rheumatoid arthritis(RA)was evaluated.MTX(10 mg a time,once a week)was used in patients with anti-CCP antibody positive early RA,and the therapeutic effect was observed after 6 months.Results The sensitivity of anti-CCP antibody was 74.91 %,with a high specificity(94.74%)in RA.The sensitivity of RF was 77.42 %,and the specificity was 76.31%.The specificity of the RF was significantly lower than anti-CCP antibody(P0.05).The positive rates of anti-CCP antibody in the early arthritis patients and advanced stage arthritis patients were 61.54% and 83.33%.There was no significant difference between them(P0.05).There was positive correlation among serum levels of anti-CCP antibody,RF and ESR(P0.05),but negative with CRP(P0.05).After 6 months of MTX treatment,the improvement rate was 50%.Conclusion Anti-CCP antibody has better sensitivity and specificity for rheumatoid arthritis,it is a useful laboratory marker for early diagnosis of rheumatoid arthritis.Read More
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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Cited By Count: 1
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