Title: Correlation and clinical significance between expression of PIK3CA and drug resistance in colorectal carcinoma tissues
Abstract: OBJECTIVE:To explor the correlation and clinical significance between the expression of PIK3CA and multidrug resistance gene products LRP,GST-π and Topo Ⅱ in colorectal carcinoma tissues.METHODS:The expressions of PIK3CA,LRP,GST-π and Topo Ⅱ in 108 patients with colorectal carcinoma were detected by Max VisionTM immunohistochemical technique.The relationship of PIK3CA and drug resistance in colorectal cancer was analyzed.RESULTS:1)The PIK3CA expression was correlated with the degree of tumor differentiation,TNM stage and lymph node metastasis(P0.05);2)The PIK3CA expression was correlated with GST-π and Topo Ⅱ.CONCLUSION:The PIK3CA expression is correlated with MDR,therefore,detecting the expressions of PIK3CA has the important significance with regard to choosing the individual chemotherapy and prediction of prognosis.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot