Title: The Concentration of Plasma Homocysteine in the Patients with Acute Cerebral Infarction
Abstract: Objective To analyze the relationship between plasma homocysteine and cerebral infarction. Methods Plasma homocysteine was determined by fluorescence polarization immunoassay in 136 patients with acute cerebral infarction and 70 controls. 15 patients with hyperhomocysteinemia received remedy of vitamin supplement. Multivariate regression analysis was used to determine the risk factors for cerebral infarction. Results Plasma homocysteine of patients with CI was higher than that of controls (P0.001). The prevalence of hyperhomocysteinemia in patients with cerebral infarction and controls was 18.4% and 4.3%, respectively (χ2=7.819, P=0.005). Median contents of homocysteine for mild, moderate, and severe CI was 10.94±4.93, 14.69±6.51, 15.80±6.89 μmol/L, respectively (P0.05). Logistic regression found plasma homocysteine was independently associated with CI (P0.001). After two weeks treatment with vitamins supplement, the content of plasma homocysteine of that 15 patients with hyperhomocysteinemia was lowered (P0.001), while plasma folate and vitamin B12 were increased (P0.05). Conclusions Mild-moderate hyperhomocysteinemia was common in the patients with CI, it was an independent risk factor for CI. Plasma homocysteine was associated with the patient's condition. The level of plasma homocysteine could be lowered effectively by vitamin supplement.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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