Title: The protective effects of Ginkgo biloba extract phosphatidylcholide complex on the learning and memory impairment in cerebral ischemia rats
Abstract: OBJECTIVE To study the protective effects of Ginkgo biloba extract phosphatidylcholide complex (Gb-PC) on the learning and memory impairment in rats of vascular dementia (VD) , and discuss the relevant mechanisms. METHODS VD model rats were made by repeated cerebral ischemia-reperfusion. Step-through and morris water maze experiments were used to detect the learning and memory ability. The activities of monoamine oxidase (MAO) and superoxide dismutase (SOD) and the contents of malonyldialdehyde (MDA) in the hippocampus tissues were measured to explore the possible mechanisms. RESULTS Gb-PC obviously improved the learning and memory ability of VD rats, and lowered the content of MDA, restored the lowered activity of SOD and inhibited the activity of MAO in the hippocampus tissues. CONCLUSION It was concluded that Gb-PC, to a certain degree, improved the learning and memory ability of VD rats. The relevant mechanisms may be related to increasing antioxidase activities, decreasing of damage of lipid peroxidative to biomembrane and inhibiting the activity of MAO in the hippocampus tissues.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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