Title: Studies on the preventive and therapeutic effects of rhodosin on rats with Alzheimer's disease
Abstract: Objective To study the protective and therapeutic effects of Rhodosin, the extranctant of medical plants named Rhodiola Sachinsis A.Bor, on the model rats of Alzheimer's disease(AD). Methods D galactose was intraperitoneally injected in Rats for 6 weeks and Aβ 1 40 was injected into both sides of the hippocampus to make AD models. Rhodosin was intraperitoneally injected in rats for 4 weeks to determine the protective and therapeutic effects on rats with AD.Y maze test and step though test were used to determine the ability of learning and memory. The content of lipofuscin in central cortex, the viscous coefficient of mitochondrial membrane, the activity of superoxide dismutase and the content of malondialdehyde in hippocampus were determined. And the apoptosis of hippocampus neurons was determined with transmission electron microscopy(TEM). Results The Rhodosin as an antioxidant significantly improved learning and memory deficits in rats with AD and reduced the increase in the activity of SOD, the content of MDA, the viscous coefficient and the content of lipofuscin to their normal levels, and it also showed the protective effects of apoptosis. Conclusion Rhodosin had preventive and therapeutic effects on rats with AD probably by affecting the free radical levels in rats.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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Cited By Count: 2
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