Title: Nonalcoholic Fatty Liver Disease and Insulin Resistance in Obese Children
Abstract: Objective To investigate the relationship between nonalcoholic fatty liver disease (NAFLD) and insulin resistance in obese children.Methods The contractive study was taken to measure the height and weight of the body,and the levels of blood sugar,lipid and uric acid of the children patients in the NAFLD group and simple obese group.Oral glucose tolerance test and insulin releasing test were performed.The body mass index (BMI) and homeostasis model assessment-insulin resistance (HOMA-IR) were calculated.Results The BMI,total cholesterol (TC),triglyceride (TG),lower density lipoprotein-cholesterol (LDL-C) and uric acid of children in NAFLD group were obviously higher than those in simple obese group,while the value of 2-h postprandial blood glucose (2h-PG) in oral glucose tolerance test and HOMA-IR were significantly elevated in the NAFLD compared with those in simple obese group (P0.05).Conclusion The obese children complicated by NAFLD have a severe insulin resistance and an metabolite disturbance of serum lipid,and insulin resistance may be one of the significant pathogenesis for NAFLD.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot