Title: Relationship between serum adiponectin,obesity and insulin resistance in nonalcoholic fatty liver disease
Abstract: [Objective] To assess the relationship between serum adiponectin, obesity and insulin resistance in nonalcoholic fatty liver disease (NAFLD). [Methods] Fasting serum adiponectin in 45 NAFLD patients and 31 matched normal control subjects was measured by ELISA. Insulin resistance by homeostasis model (HOMA), height, weight, waist circumstance, hip girth, waist to hip ratio (WHR), body mass index (BMI), blood pressure, blood glucose, total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, alanine aminotransferase (ALT), γ-glutamyl transpeptidase (GGT) and fasting insulin were measured as well. [Results] serum adiponectin levels decreased obviously in NAFLD patients as compared to controls [(7.07±1.10) ng/mL vs (10.68±1.45) ng/mL, P 0.05]. There was no significant correlation between serum adiponectin (dependent variable) and sex, age, blood pressure, and a number of biochemical variables (glucose, total cholesterol, LDL-cholesterol). Serum adiponectin level was in correlation with fasting insulin and HOMA-IR, ALT, GGT, WHR, BMI, triglyceride, HDL-cholesterol. [Conclusion] Serum adiponectin levels decreased and were in significant correlation with insulin resistance in NAFLD patients. Insulin resistance may have a direct effect on the cause of NAFLD. Furthermore, central obesity was considered as a risk factor of NAFLD. Central obesity and decreased adiponection may have influence on insulin resistance and further induce NAFLD.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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