Title: Analysis on the therapeutic effect of thalidomide combined with routine chemotherapy for acute leukemia
Abstract: Objective To explore the therapeutic effect of thalidomide combined with routine chemotherapy for acute leukemia.Methods Forty patients with acute leukemia were randomly divided into trial group and conventional group,20 cases in each group.Meanwhile,another 20healthy people by physical examination were selected as control group.The conventional group was given conventional chemotherapy,while the trial group was added thalidomide based on the treatment of the conventional group.The clinical effects and incidence of adverse reactions of trial group and conventional group were compared,and the changes of vascular endothelial growth factor(VEGF),VEGF receptor,basic fibroblast growth factor(bFGF)and micro vascula density(MVD)levels were observed in three groups.Results The total effectiveness rate in trial group was notably higher than that in conventional group.After treatment,the levels of VEGF,VEGFR and MVD decreased significantly compared with treatment before,and the decreased degreesof trial group were bigger.The levels of VEGF and bFGF in trial group and conventional group as well as VEGFR level in trial group before treatment were all higher than those of the control group evidently.The patients in two groups suffered from bone marrow suppression,nausea and vomiting to varying degrees.Linear correlation analysis revealed that the levelsof VEGF,VEGFRand MVD in plasma had a certain correlation with clinical effects.Conclusion Thalidomide combined with routine chemotherapy can effectively improve the clinical effect,inhibit the expression of plasma VEGF and VEGFRaswell as the generation of capillariesin bone marrow,and has a significant therapeutic effect in resisting the angiogenesis of acute leukemia.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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