Title: Correlation of expression of heparanase with clinicopathologic parameters and microvessel density in gallbladder cancer
Abstract: Objective To study the correlation of heparanase expression in gallbladder cancer with clinicopathologic parameters and microvessel density(MVD).Methods The expressions of heparanase and CD34 were detected by immunohistochemistry SP method in 61 cases with gallbladder cancer.The correlation of heparanase expression and clinicopathologic parameters and MVD was analysed.Results The positive expression rate of heparanase in gallbladder cancer was higher in the patients with lymph node metastasis and TNM stage Ⅲ-Ⅴ than that in those without lymph node metastasis and TNM stage Ⅰ-Ⅱ(P0.05).MVD in gallbladder cancer was higher in the cases with positive expression of heparanase than that in those with negetive expression(P0.05).ConclusionHeparanase is highly expressed in gallbladder cancer,which is related to metastasis and clinical stages of gallbladder cancer.Heparanase can promote the metastasis and angiogenesis of gallbladder cancer.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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