Title: Therapeutic effect evaluation of recombinant tissue plasminogen activator in hyper acute cerebral infarction
Abstract: Objective: To evaluate the efficacy and safety of recombinant tissue plasminogen activator in hyper acute cere-bral infarction. Methods: 128 patients within 6 hours after the onset of stroke were divided into two groups randomly. The people in one group were cured by traditional therapeutic means, while people in another group were given rt-PA in addi -tion to the traditional therapeutic means. Concretely speaking, the total dosage was 0.9 mg/kg, and the maximum dosage was 90 mg. Firstly, 10% of the dosage was injected into vein within 1 minute, then the rest was dropped into vein within 60 minutes. The CSS scores and BI were used to evaluate effects before treatment and at 2 h, 12 h, 24 h, 3 d, 7 d, 14 d, 30 d and 90 d after treatment in two groups. Results: The CSS scores and BI of group two which was given rt-PA were improved at these evaluated time points (P0.01), and efficiency of this group was obviously higher than that of another (P0.01), also the bleeding rate was lower. Conclusion: rt-PA in the treatment of ACI patients within 6 hours after the onset is efficient and safe.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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