Title: Expression of cyclooxygenase-2 in meningioma and its relationship with microvessel density
Abstract: Objective To investigate the expression of cyclooxygenase 2(COX 2) and microvessel density(MVD). in meningioma and its significance. Methods The COX 2 protein and MVD were examined by immunohistochemicalstain. in 72 brain meningioma tissues and 15 non tumor brain tissues. COX 2 of expression to be measured by score table.Results Tile expression of COX 2 protein in meningioma tissues(average 3 24) was significantly higher than that in non tumor brain tissues(average 0 43), and it increased parallel with the elevation of malignant degree. Meningioma, there was appositive correlation between COX 2 and MVD( r =0 627, P 0 05). Conclusion The overexpression of COX 2 perhapse associated with the occurrence and development of meningioma, and it may be contributes to tumor angiogenesis.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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