Title: Clinical Value of Serum Human Epididymial Protein 4 in The Diagnosis of Ovarian Cancer
Abstract: [Purpose] To evaluate the diagnostic value of human epididymal protein 4(HE4) for ovarian cancer.[Methods] Forty-eight cases with ovarian cancer,33 cases with benign ovarian tumor and 38 cases of healthy control were enrolled.Serum HE4 and carbohydrate antigen 125(CA125) level were detected by enzyme-linked immunosorbent assay and chemiluminescence assay.[Results] The area of ROC curve of HE4 for ovarian cancer diagnosis was 0.921(95%CI: 0.887 ~0.955).The sensitivity was 66.7% and specificity was 84.5% while HE4 cut-off was 86.5pmol/L.The area of ROC curve of CA125 for ovarian cancer diagnosis was 0.902(95%CI: 0.857 ~0.947).The sensitivity was 62.57% and specificity was 81.7% while CA125 cut-off was 48.2 U/ml.The area of ROC curve of HE4 combined with CA125 for ovarian cancer diagnosis was 0.947(95%CI:0.914~0.980).Serum HE4 level in patients with stage Ⅲ~ Ⅳ or with lymph node metastasis was significantly higher than in stage Ⅰ~Ⅱ or without lymph node metastasis respectively(P0.05).[Conclusion] HE4 might be used as a serum marker in the diagnosis of ovarian cancer.It can improve the efficiency of diagnosis of ovarian cancer when combined with CA125.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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