Title: Investigation on the application value of human sapiens epididymis specific protein 4 and cancer antigen 125 in the diagnosis for ovarian cancer
Abstract: Objective To investigate the application value of human sapiens epididymis specific protein 4(HE4)and carbohydrate antigen 125(CA125)in the diagnosis of ovarian cancer.Methods The serum levels of HE4 and CA125in 574 adnexal mass patients or post-operation patients were detected by automatic electrochemical luminescence immunity analyzer of Roche Cobase 601.According to clinical and pathological diagnosis,the 574 female patients were divided into three groups,18 patients in ovarian cancer group,12 patients accepted ovarian cancer operation in post-operation group,544 patients with benign tumor in benign disease group.The differences on the levels of HE4 and CA125in the three groups were compared,and the performances of HE4 and CA125in the diagnosis of ovarian cancer were determined by the receiver operating characteristic(ROC)curve.Results The median levels of HE4 and CA125in the ovarian cancer group,benign disease group and post-operation group were 262.0pmol/L and373.3U/mL,48.0pmol/L and 17.2U/mL,49.2pmol/L and 18.4U/mL respectively.The upper limit of normal for HE4 in diagnosing for ovarian cancer was 115.7pmol/L,and the sensitivity was 94.4%,the specificity was96.94%,the area under the ROC curve was 0.984.The sensitivity,specificity and area under the ROC curve of CA125 were 83.3%,75.4%and 0.911 respectively.Conclusion The detection of HE4 is superior to the detection of CA125,and could be used in the assist diagnosis of ovarian cancer separately.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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