Title: Intervention Effect of Gualou Xiebai(GLXB) decoction on the Superoxide Dismutase and Malondialdehyde in Serum and Bronchoalveolar Lavage Fluid during the Formation Stage of Rat's Pulmonary Fibrosis
Abstract: Objective: To explore the mechanism of intervention effect of Gualou Xiebai(GLXB) decoction on rat's pulmonary fibrosis during its Formation Stage.Methods: After the model rats with pulmonary fibrosis was made by bleomycin A 5(BLMA 5),the rats in herbal groups were administrated with the solution made by GLXB decoction from the day 14,and sacrificed on day 28.Then superoxide dismutase(SOD) activity and the contents of malondialdehyde(MDA)of rat's serum and bronchoalveolar lavage fluid(BALF) in each group were determined and compared.Results: The SOD activity of rats' serum and BALF in the model group was less than the activity of them in control group,the MDA contents of rats' serum and BALF in the model group were more than the contents of them in the control group,the SOD activity of rats' serum and BALF in GLXB decoction group were more than the activity of them in the model group,the MDA contents of rats' serum and BALF in GLXB decoction group were less than the contents of them in the model group;The SOD activity and MDA contents of rats' serum was positively correlated with the SOD activity and MDA contents of rats' BALF.Conclusion: GLXB decoction had the functions of restraining the decline of the SOD activity and the increase of MDA contents of the mode with pulmonary fibrosis and serum.The SOD activity and MDA contents of serum indirectly reflected the level of lipid peroxidation and antioxidation of the lung.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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