Title: Expression and Clinical Significance of ULBP2 in Pancreatic Adenocarcinoma
Abstract: Objective:To investigate the expression of ULBP2 in pancreatic adenocarcinoma and its clinical significance. Methods:Immunohistochemistry was used to detect the expression of ULBP2 in pancreatic adenocarcinoma tissues samples.The relation between the expression of ULBP2 and the clinical pathological factors were statistically analyzed.Results:The positive expession rate of ULBP2 in 40 pancreatic adenocarcinoma tissues samples was 87.5%(35/40).Compared to the expression of ULBP2 in normal pancreatic tissues samples,the expression of ULBP2 in pancreatic adenocarcinoma tissues samples had a statistically significant difference(X 2 =21. 865,P0.01).ULBP2 expression rate in pancreatic adenocarcinoma was related to tumor distant metastasis(X 2 =4.322,P=0.038)and histologic grade(X 2 =6.400, P=0.041).Conclusions:ULBP2 may play an important role in the tumorigenesis and progression of pancreatic adenocarcinoma.ULBP2 is expected to become a target for immunotherapy of pancreatic adenocarcinoma.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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