Title: Contrast enhanced ultrasound in evaluating the therapeutic effects of microwave coagulation on hepatic cellular cancer
Abstract: Objective:To investigate the role of contrast enhanced ultrasound (CEUS) in evaluating the therapeutic effects of microwave coagulation on hepatic cellular cancer. Methods: Thirty patients (20 men, 10 women) with 33 tumors, which were confirmed by pathological findings, were examined by CEUS at low MI (0.05-0.08) after intravenous injection of SonoVue, 0.5 hour and 2 weeks after microwave coagulation to evaluate the therapeutic effect. The results were recorded and compared with those from enhanced CT. Twelve therapy areas which were diagnosed as tumor residual with CEUS or enhanced CT were examined by biopsy pathology,and the 18 left areas were followed up for a period of more than six months. Results: Twenty-two lesions after microwave coagulation examined with CEUS showed complete necrosis. The other eleven lesions which showed early-stage marginal local enhancement were diagnosed as tumor residua. According to biopsy pathology at more than 6 months of follow-up, two lesions under the combination-therapy with microwave coagulation and TACE were misdiagnosed with enhanced CT. The accuracy of enhanced CT and CEUS was 94% (31/33) and 97% (32/33), respectively, and the difference was not statistically significant (P0.05). Conclusion:Contrast enhanced ultrasound can not only help to assess the therapeutic effect of microwave coagulation on HCC but can effectively assess the effect of microwave coagulation combined with TACE. And the latter effect may be superior to that of enhanced CT, for the evaluating effect of CEUS is not influenced by retention of iodized oil.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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