Title: Effect of Intensive Insulin Treatment on β-cell Function of Newly Diagnosed Type 2 Diabetics
Abstract: Objective To investigate the effect of intensive insulin treatment on β-cell function in type 2 diabetes mellitus (DM Ⅱ) patients newly diagnosed.Methods Totally 41newly diagnosed DMⅡpatients with fasting blood glucose (FBG) above 11.1mmol/L were treated with short-acting insulin subcutaneous injection 3 min of pre-meals and mid-acting insulin subcutaneous injection before bedtime.The initial dose of short acting and mid-acting insulin were 0.5 IU·kg-1·d-1 and the initial dosage mid-acting insulin accounted fro 20% of the total insulin dosage.The aim of target BG is set up as follow: FBG 4.4~6.1 mmol/L,2-h postprandial blood glucose (PPG) 4.4~8.0 mmol/L.The insulin dose was modified according to target BG,the treatment was applied for 3 weeks.Twenty-four hours later of insulin injection stop,FPG,PBG,HbA1c,OGTT and IRT were measured for contrast before and after treatment.The HOMA-β cell secretion index (HOMAβ) and Homa insulin resistance index (Homa-IR) were calculated according to the homeostasis model.Results Before treatment,the levels of FPG,PPG,HbA1c,FINS,HOMA-β,and HOMA-IR were respectively (12.36±0.75)mmol/L,(20.1±2.3)mmol/L,(10.7±0.5)%,(5.7±0.7)μU/ml,(52±11),and (3.2±0.5); after treatment they were respectively (5.67±0.25)mmol/L,(7.8±1.4)mmol/L,(7.1±0.4),(10.4±1.2)μU/ml,(103±33),and (2.6±0.3),with significant differences before and after treatment (P0.01).Conclusion The intensive insulin treatment can improve β-cell secretion function and decrease insulin resistance for newly diagnosed DM Ⅱpatients with high fasting blood glucose.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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