Title: Transient insulin pump intensive treatment for newly diagnosed type 2 diabetes mellitus without first phase insulin secretion
Abstract: Objective To evaluate the hypoglycemic efficacy of continuous subcutaneous insulin infusion(CSII) with transient insulin pump and its influences on beta cells in patients with newly diagnosed type 2 diabetes mellitus(2-DM) associated with hyperglycemia.Methods 20 patients with newly diagnosed 2-DM with fasting plasma glucose(FPG)≥11.1 mmol/L received CSII intensive treatment for 2 weeks.Before and after treatment,the levels of FPG and 2hPG were measured.An intravenous glucose tolerance test(IGTT) was performed.The first phase insulin secretion was observed,and the area under the curve(AUC) of insulin and C peptide were calculated.The beta cell exponents(Homa β) and insulin resistance indexes(Homer IR) were also calculated.Results After 2-week CSII intensive treatment,decreased FPG and 2hPG were found in 20 patients(P0.01),and they reached to the blood glucose control standard on day 4.2±1.7.During IGTT,most patients were found with different degree of first phase insulin secretion,and AUC and Homa β increased significantly,and Homer IR decreased significantly(P0.01).Conclusion Transient CSII intensive treatment of newly diagnosed 2-DM patients associated with hyperglycemia can rapidly and stably control the blood glucose and improve the beta cell function and insulin resistance.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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