Title: Expression of PTEN,P63 and P27 protein and its clinical pathological significance in patients with lung cancer
Abstract: Objective To detect the expression levels of PTEN,P63 and P27 protein in lung cancer tissue,and to elucidate its association with clinical pathological factors for lung cancer.Methods Immunohistochemical S-P method was used to examine the expression levels of PTEN,P63 and P27 protein in 66 cases of lung cancer tissue(lung cancer group) and 10 cases of normal lung tissue(control group).Results The positive expression rates of PTEN,P63 and P27 were significantly higher in lung cancer group than those in control group(27.3% vs 90.0%;33.3% vs 70.0%;21.2% vs 70.0%,respectively),all P0.01.The positive expression rate of PTEN and P63 were both 55.6% in well and moderately differentiated squamous carcinoma subgroup,and 0.0% in poorly differentiated squamous carcinoma subgroup.The double positive rate of PTEN and P63,PTEN and P27,as well as P63 and P27 was 13.6%,6.2% and 9.1% respectively.The expression of PTEN and P63 were positively correlative(P0.01).Multivariate Cox analysis on prognostic factors showed PTEN and P27 were negatively correlative.There was a statistical significance.Conclusion There is a low expression of PTEN,P63 and P27 protein in lung cancers while a high expression in normal lung tissues,which indicates that the low expression of PTEN,P63 and P27 gene may play a role in the pathogenesis of lung cancer.The positive expression rate of PTEN and P63 is significantly higher in well and moderately differentiated squamous carcinoma tissue than that in poorly differentiated squamous carcinoma tissue,which indicates that the expression levels of PTEN and P63 are associated with squamous cancer cell differentiation degree.The expression of PTEN and P63 are positively correlative,and the two proteins may exert a certain synergistic effect.The determination of PTEN,P63 and P27 protein can be used as an important marker in the diagnosis,evaluation of malignant degree and prognosis of lung cancer.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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