Title: Effects of high-dose ambroxol on serum TNF-α and IL-6 of patients with pulmonary injury caused by acute paraquat poisoning
Abstract: Objective:To investigate the effects of high-dose ambroxol on serum TNF-α and IL-6 of patients with pulmonary injury caused by acute paraquat poisoning. Methods:Thirty-one patients with pulmonary injury caused by acute paraquat poisoning were randomly divided into treatment group (n=16) and control group (n=15). Both groups were treated with conventional therapy. Treatment group were given ambroxol 20 mg/(kg·d)intravenously guttae every 12 h for 3 days. Serum TNF-α and IL-6 were measured by ELISA before and after treatment,and lung injury score (LIS) was also assessed in all subjects. Results:Levels of serum TNF-α and IL-6,and LIS in both groups were significantly lower after treatment(P0.01). Furthermore,treatment group showed significantly more lower than control group (P0.05). Conclusion:High-dose ambroxol can inhibit exrpression of serum TNF-α and IL-6,reduce the degree of pulmonary injury caused by acute paraquat poisoning.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot