Title: On expression of VEGF-C and its receptor in breast carcinoma tissue and in peritumoral tissue and their clinic significance
Abstract: Objective To study the expression of VEGF-C and its receptor in breast carcinoma tissue and in peritumoral tissue,as well as their clinic significance.Methods Immunohistochemistry SP method was used to examine the expression of VEGF-C and VEGFR3 in 70 cases of breast cancer and in its peritu- moral tissue.Results In all 70 cases of breast cancer,the positive expression rate of VEGF-C in breast car- cinoma tissue was 78.6 %,and its rate in peritumoral tissue was 54.3 %.There was a significant stastistic dif- ference between the two groups(P0.01).The positive lymph vessel of VEGFR3 was higher in peritumoral tis- sue(10.306±6.158)than that in breast carcinoma tissue(7.896±5.565)(P0.01).The expression of VEGFR3 was closely correlated with VEGF-C expression(r=0.66,P0.05).The positive expression rate of VEGF-C in lymph node metastasis group was 87.5 %,and in no lymph node metastasis group was 71.1%(P0.01). The VEGFR3 positive vessels in lymph node metastasis group(12.484±6.505)was significantly higher than in non-lymph node metastasis group(8.471±6.017)(P0.01).Conclusion The positive expression of VEGF-C is located in breast cancer cells,and VEGFR3,the receptors of VEGF-C is located in lymphatic vascular en- dothelial cells of tumor stroma tissue and peritumoral tissue.VEGF-C and VEGFR3 are closely correlated to the lymphangiogenesis and lymph node metastasis of breast cancer.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot