Title: Effect of Songling Xuemaikang Capsule on Cerebral TNF-α of Rats after Focal Cerebral Ischemia Injury
Abstract: Objective:To study the effect of Songling Xuemaikang preconditioning on the expression of tumor necrosis factor-α after focal cerebral ischemia injury in rats.Methods:36 adult male Sprague-Dawley rats were randomly divided into four groups in which the sham-operation group(n=12) and the control group(n=12) were both treated with 1ml/100g isotonic saline,and the preconditioning groups of 4w were treated with 937.50mg/kg of SL-xmk before received 2h of MCAO followed by 24h reperfusion except sham-opera-tion group.The brain water content and infarct area in right hemisphere were observed after ischemia for 2h followed by 24h reperfusion,then immunohistochemistry was used to detect the expression of TNF-α of ischemic brain tissue.Results:The pretreatment 4w periods of SL-xmk could significantly reduce ischemic brain tissue water content and infarct area in right hemisphere.Compared with the control group,the expression of TNF-α in ischemic brain tissue decreased obviously.Conclusion:SL-xmk pretreatment may have certain inhibi-tion on the expression of tumor necrosis factor-α after focal cerebral ischemia-reperfusion injury.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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