Title: Changes of BNP, ANP, ET and CRP Levels in the Plasma of Patientswith Acute Myocardial Infarction
Abstract: To explore the pathogenesis and provide evidence for the diagnosis, therapy and prognosis of acute myocardial infarction (AMI) by observing the levels of brain natriuretic peptide(BNP), endothelins(ET), C-reactive protein(CRP) and atrial natriuretic peptide(ANP) in plasma of the patients, BNP, ET, CRP and ANP levels in plasma of 46 AMI patients before and after therapy and 30 normal controls were detected by ELISA and immunoradiometric assay, respectively.Results showed that there were significant differences in BNP, ET, CRP and ANP levels in patients with AMI before and after therapy( P 0.01), and the differences also existed in AMI group and normal controls( P 0.01).There was positive correlation between BNP and CRP before therapy( r =0.874) and after therapy( r =0.654), as well as ANP and ET before therapy. Though the ANP level returned to normal( P 0.05) after thrombolysis and other supporting therapy, the decreased BNP, ET and CRP were still significantly higher than those of control( P 0.05).The changes of BNP, ANP, ET and CRP indicate that they involved in the occurrence and development of AMI, especially in the formation and disruption of atheromatous plaquemay and thrombosis. So the detection of BNP, ANP, ET and CRP levels was significant to the diagnosis, therapy and prognosis judgement.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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