Title: Studies on the intestinal absorption kinetics of mycophenolatemofetil in rats
Abstract: Objective:To study the absorptivecharacters of MMF and MPAin rats' intestines.Methods:An in situ intestinal perfusion model was employed to investigate systemically the absorptive characterof MMF and MPA.The effects of pH value,absorption site and drug concentration on drug absorption were studied.Results:The absorption rate constant(Ka)of MMF were 0.0176,0.0219,0.0311,0.0333 h-1 at duodenum,jejunum,ileum,and colon respectively(P0.05).Within the range of 5.4-7.4,pH value had no influence on absorption of drug.The Ka of MMF were 0.0964,0.1325,0.1655,0.1222 h-1 at the concentration of 65,135,200,300 μg·mL-1 while the Ka of MPA were kept unvaried basically.Conclusion:MMFwere absorbed at all the segment of intestine in rats.It was suggested that MMF could be designed as sustained-release dosage form.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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