Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2338193405', 'doi': 'https://doi.org/10.1007/s00432-016-2157-9', 'title': 'Low-dose DNA-demethylating agent enhances the chemosensitivity of cancer cells by targeting cancer stem cells via the upregulation of microRNA-497', 'display_name': 'Low-dose DNA-demethylating agent enhances the chemosensitivity of cancer cells by targeting cancer stem cells via the upregulation of microRNA-497', 'publication_year': 2016, 'publication_date': '2016-04-13', 'ids': {'openalex': 'https://openalex.org/W2338193405', 'doi': 'https://doi.org/10.1007/s00432-016-2157-9', 'mag': '2338193405', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27075177'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/s00432-016-2157-9', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S10075937', 'display_name': 'Journal of Cancer Research and Clinical Oncology', 'issn_l': '0171-5216', 'issn': ['0171-5216', '1432-1335'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100383351', 'display_name': 'Lin Liu', 'orcid': 'https://orcid.org/0000-0003-4748-8755'}, 'institutions': [{'id': 'https://openalex.org/I2802939634', 'display_name': 'Chinese PLA General Hospital', 'ror': 'https://ror.org/04gw3ra78', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802939634']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lin Liu', 'raw_affiliation_strings': ['Department of General Surgery, PLA General Hospital, Beijing, 100853, China'], 'affiliations': [{'raw_affiliation_string': 'Department of General Surgery, PLA General Hospital, Beijing, 100853, China', 'institution_ids': ['https://openalex.org/I2802939634']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100762307', 'display_name': 'Lin Chen', 'orcid': 'https://orcid.org/0000-0002-8126-3333'}, 'institutions': [{'id': 'https://openalex.org/I2802939634', 'display_name': 'Chinese PLA General Hospital', 'ror': 'https://ror.org/04gw3ra78', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802939634']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lin Chen', 'raw_affiliation_strings': ['Department of General Surgery, PLA General Hospital, Beijing, 100853, China'], 'affiliations': [{'raw_affiliation_string': 'Department of General Surgery, PLA General Hospital, Beijing, 100853, China', 'institution_ids': ['https://openalex.org/I2802939634']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101827002', 'display_name': 'Xuan Wu', 'orcid': 'https://orcid.org/0000-0003-0239-7999'}, 'institutions': [{'id': 'https://openalex.org/I2802939634', 'display_name': 'Chinese PLA General Hospital', 'ror': 'https://ror.org/04gw3ra78', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802939634']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xuan Wu', 'raw_affiliation_strings': ['Department of Immunology, Institute of Basic Medicine, PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, Institute of Basic Medicine, PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China', 'institution_ids': ['https://openalex.org/I2802939634']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100331061', 'display_name': 'Xiang Li', 'orcid': 'https://orcid.org/0000-0002-5147-8368'}, 'institutions': [{'id': 'https://openalex.org/I2802939634', 'display_name': 'Chinese PLA General Hospital', 'ror': 'https://ror.org/04gw3ra78', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802939634']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiang Li', 'raw_affiliation_strings': ['Department of Immunology, Institute of Basic Medicine, PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, Institute of Basic Medicine, PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China', 'institution_ids': ['https://openalex.org/I2802939634']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048373926', 'display_name': 'Yang Song', 'orcid': 'https://orcid.org/0000-0002-2093-9387'}, 'institutions': [{'id': 'https://openalex.org/I2802939634', 'display_name': 'Chinese PLA General Hospital', 'ror': 'https://ror.org/04gw3ra78', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802939634']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yang Song', 'raw_affiliation_strings': ['Department of Microbiology, PLA General Hospital, Beijing, 100853, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, PLA General Hospital, Beijing, 100853, China', 'institution_ids': ['https://openalex.org/I2802939634']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025783245', 'display_name': 'Qian Mei', 'orcid': 'https://orcid.org/0000-0003-4648-7232'}, 'institutions': [{'id': 'https://openalex.org/I2802939634', 'display_name': 'Chinese PLA General Hospital', 'ror': 'https://ror.org/04gw3ra78', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802939634']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qian Mei', 'raw_affiliation_strings': ['Department of Immunology, Institute of Basic Medicine, PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, Institute of Basic Medicine, PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China', 'institution_ids': ['https://openalex.org/I2802939634']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102929308', 'display_name': 'Jing Nie', 'orcid': 'https://orcid.org/0000-0001-5080-6553'}, 'institutions': [{'id': 'https://openalex.org/I2802939634', 'display_name': 'Chinese PLA General Hospital', 'ror': 'https://ror.org/04gw3ra78', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802939634']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jing Nie', 'raw_affiliation_strings': ['Department of Immunology, Institute of Basic Medicine, PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, Institute of Basic Medicine, PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China', 'institution_ids': ['https://openalex.org/I2802939634']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5067287490', 'display_name': 'Weidong Han', 'orcid': 'https://orcid.org/0000-0003-3207-3899'}, 'institutions': [{'id': 'https://openalex.org/I2802939634', 'display_name': 'Chinese PLA General Hospital', 'ror': 'https://ror.org/04gw3ra78', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802939634']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Weidong Han', 'raw_affiliation_strings': ['Department of Immunology, Institute of Basic Medicine, PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Immunology, Institute of Basic Medicine, PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China', 'institution_ids': ['https://openalex.org/I2802939634']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3190, 'currency': 'EUR', 'value_usd': 4190, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.188, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 16, 'citation_normalized_percentile': {'value': 0.833945, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '142', 'issue': '7', 'first_page': '1431', 'last_page': '1439'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10062', 'display_name': 'MicroRNA in disease regulation', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10515', 'display_name': 'Cancer-related molecular mechanisms research', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/decitabine', 'display_name': 'Decitabine', 'score': 0.95821273}, {'id': 'https://openalex.org/keywords/demethylating-agent', 'display_name': 'Demethylating agent', 'score': 0.77594155}, {'id': 'https://openalex.org/keywords/azacitidine', 'display_name': 'Azacitidine', 'score': 0.5471843}], 'concepts': [{'id': 'https://openalex.org/C2780235182', 'wikidata': 'https://www.wikidata.org/wiki/Q1181878', 'display_name': 'Decitabine', 'level': 5, 'score': 0.95821273}, {'id': 'https://openalex.org/C2779277951', 'wikidata': 'https://www.wikidata.org/wiki/Q5255196', 'display_name': 'Demethylating agent', 'level': 5, 'score': 0.77594155}, {'id': 'https://openalex.org/C2778239845', 'wikidata': 'https://www.wikidata.org/wiki/Q412415', 'display_name': 'Cisplatin', 'level': 3, 'score': 0.70605546}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.69156224}, {'id': 'https://openalex.org/C55427017', 'wikidata': 'https://www.wikidata.org/wiki/Q1638475', 'display_name': 'Cancer stem cell', 'level': 3, 'score': 0.62642485}, {'id': 'https://openalex.org/C2777292972', 'wikidata': 'https://www.wikidata.org/wiki/Q423762', 'display_name': 'Paclitaxel', 'level': 3, 'score': 0.5834929}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.54987454}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.5472153}, {'id': 'https://openalex.org/C2776239401', 'wikidata': 'https://www.wikidata.org/wiki/Q416451', 'display_name': 'Azacitidine', 'level': 5, 'score': 0.5471843}, {'id': 'https://openalex.org/C145059251', 'wikidata': 'https://www.wikidata.org/wiki/Q310899', 'display_name': 'microRNA', 'level': 3, 'score': 0.53776115}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.46797305}, {'id': 'https://openalex.org/C190727270', 'wikidata': 'https://www.wikidata.org/wiki/Q874745', 'display_name': 'DNA methylation', 'level': 4, 'score': 0.45053998}, {'id': 'https://openalex.org/C127561419', 'wikidata': 'https://www.wikidata.org/wiki/Q224527', 'display_name': 'Downregulation and upregulation', 'level': 3, 'score': 0.43143916}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.38858315}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.37522614}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.33613288}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.27841443}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.25547484}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.10379973}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.078757346}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.058059096}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000964', 'descriptor_name': 'Antimetabolites, Antineoplastic', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D001374', 'descriptor_name': 'Azacitidine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D015854', 'descriptor_name': 'Up-Regulation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000964', 'descriptor_name': 'Antimetabolites, Antineoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001374', 'descriptor_name': 'Azacitidine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001374', 'descriptor_name': 'Azacitidine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077209', 'descriptor_name': 'Decitabine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015854', 'descriptor_name': 'Up-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/s00432-016-2157-9', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S10075937', 'display_name': 'Journal of Cancer Research and Clinical Oncology', 'issn_l': '0171-5216', 'issn': ['0171-5216', '1432-1335'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27075177', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.82}], 'grants': [{'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '81472838'}, {'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '81302166'}], 'datasets': [], 'versions': [], 'referenced_works_count': 33, 'referenced_works': ['https://openalex.org/W1160100415', 'https://openalex.org/W1584810294', 'https://openalex.org/W1609108695', 'https://openalex.org/W1677634170', 'https://openalex.org/W1842991947', 'https://openalex.org/W1905278501', 'https://openalex.org/W1953890763', 'https://openalex.org/W1975616657', 'https://openalex.org/W1976731741', 'https://openalex.org/W2000156285', 'https://openalex.org/W2007757039', 'https://openalex.org/W2020131167', 'https://openalex.org/W2022388990', 'https://openalex.org/W2029197798', 'https://openalex.org/W2032462913', 'https://openalex.org/W2034194189', 'https://openalex.org/W2036446168', 'https://openalex.org/W2055197339', 'https://openalex.org/W2062069198', 'https://openalex.org/W2063756587', 'https://openalex.org/W2064442490', 'https://openalex.org/W2067311782', 'https://openalex.org/W2081279521', 'https://openalex.org/W2089801128', 'https://openalex.org/W2098897152', 'https://openalex.org/W2102217668', 'https://openalex.org/W2111265707', 'https://openalex.org/W2114479600', 'https://openalex.org/W2115175226', 'https://openalex.org/W2116991842', 'https://openalex.org/W2147516356', 'https://openalex.org/W2161553369', 'https://openalex.org/W2397393155'], 'related_works': ['https://openalex.org/W4391645188', 'https://openalex.org/W4220981828', 'https://openalex.org/W3214341925', 'https://openalex.org/W2999114056', 'https://openalex.org/W2750605634', 'https://openalex.org/W2167485228', 'https://openalex.org/W2127851369', 'https://openalex.org/W2127289529', 'https://openalex.org/W2083462343', 'https://openalex.org/W2054507167'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2338193405', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 2}], 'updated_date': '2024-12-15T22:58:08.183684', 'created_date': '2016-06-24'}