Use of Azacitidine or Decitabine for the Up-Front Setting in Acute Myeloid Leukaemia: A Systematic Review and Meta-Analysis

Name: Work Video:
Duration: 3 min 30 s
Miriam Saiz‐Rodríguez; Jorge Labrador; Beatriz Cuevas; David Martínez‐Cuadrón; Verónica Campuzano; Raquel Alcaraz; Isabel Cano; Miguel Á. Sanz; Pau Montesinos
{'id': 'https://openalex.org/W3214341925', 'doi': 'https://doi.org/10.3390/cancers13225677', 'title': 'Use of Azacitidine or Decitabine for the Up-Front Setting in Acute Myeloid Leukaemia: A Systematic Review and Meta-Analysis', 'display_name': 'Use of Azacitidine or Decitabine for the Up-Front Setting in Acute Myeloid Leukaemia: A Systematic Review and Meta-Analysis', 'publication_year': 2021, 'publication_date': '2021-11-12', 'ids': {'openalex': 'https://openalex.org/W3214341925', 'doi': 'https://doi.org/10.3390/cancers13225677', 'mag': '3214341925', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/34830832', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/8616518'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/cancers13225677', 'pdf_url': 'https://www.mdpi.com/2072-6694/13/22/5677/pdf?version=1637214031', 'source': {'id': 'https://openalex.org/S168415115', 'display_name': 'Cancers', 'issn_l': '2072-6694', 'issn': ['2072-6694'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.mdpi.com/2072-6694/13/22/5677/pdf?version=1637214031', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5083903905', 'display_name': 'Miriam Saiz‐Rodríguez', 'orcid': 'https://orcid.org/0000-0002-1660-3135'}, 'institutions': [{'id': 'https://openalex.org/I4210115949', 'display_name': 'Hospital Universitario de Burgos', 'ror': 'https://ror.org/01j5v0d02', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210115949']}, {'id': 'https://openalex.org/I46176106', 'display_name': 'Universidad de Burgos', 'ror': 'https://ror.org/049da5t36', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I46176106']}], 'countries': ['ES'], 'is_corresponding': True, 'raw_author_name': 'Miriam Saiz-Rodríguez', 'raw_affiliation_strings': ['Department of Health Sciences, University of Burgos, 09001 Burgos, Spain', 'Research Unit, Fundación Burgos por la Investigación de la Salud (FBIS), Hospital Universitario de Burgos, 09006 Burgos, Spain'], 'affiliations': [{'raw_affiliation_string': 'Research Unit, Fundación Burgos por la Investigación de la Salud (FBIS), Hospital Universitario de Burgos, 09006 Burgos, Spain', 'institution_ids': ['https://openalex.org/I4210115949']}, {'raw_affiliation_string': 'Department of Health Sciences, University of Burgos, 09001 Burgos, Spain', 'institution_ids': ['https://openalex.org/I46176106']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025193090', 'display_name': 'Jorge Labrador', 'orcid': 'https://orcid.org/0000-0002-3696-0287'}, 'institutions': [{'id': 'https://openalex.org/I4210115949', 'display_name': 'Hospital Universitario de Burgos', 'ror': 'https://ror.org/01j5v0d02', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210115949']}], 'countries': ['ES'], 'is_corresponding': True, 'raw_author_name': 'Jorge Labrador', 'raw_affiliation_strings': ['Hematology Department, Hospital Universitario de Burgos, 09006 Burgos, Spain', 'Research Unit, Fundación Burgos por la Investigación de la Salud (FBIS), Hospital Universitario de Burgos, 09006 Burgos, Spain'], 'affiliations': [{'raw_affiliation_string': 'Research Unit, Fundación Burgos por la Investigación de la Salud (FBIS), Hospital Universitario de Burgos, 09006 Burgos, Spain', 'institution_ids': ['https://openalex.org/I4210115949']}, {'raw_affiliation_string': 'Hematology Department, Hospital Universitario de Burgos, 09006 Burgos, Spain', 'institution_ids': ['https://openalex.org/I4210115949']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036922520', 'display_name': 'Beatriz Cuevas', 'orcid': 'https://orcid.org/0000-0001-7555-3361'}, 'institutions': [{'id': 'https://openalex.org/I4210115949', 'display_name': 'Hospital Universitario de Burgos', 'ror': 'https://ror.org/01j5v0d02', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210115949']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Beatriz Cuevas', 'raw_affiliation_strings': ['Hematology Department, Hospital Universitario de Burgos, 09006 Burgos, Spain'], 'affiliations': [{'raw_affiliation_string': 'Hematology Department, Hospital Universitario de Burgos, 09006 Burgos, Spain', 'institution_ids': ['https://openalex.org/I4210115949']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011914281', 'display_name': 'David Martínez‐Cuadrón', 'orcid': 'https://orcid.org/0000-0001-7540-4091'}, 'institutions': [{'id': 'https://openalex.org/I3019010403', 'display_name': 'Hospital Universitari i Politècnic La Fe', 'ror': 'https://ror.org/01ar2v535', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3019010403', 'https://openalex.org/I4210166036']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'David Martínez-Cuadrón', 'raw_affiliation_strings': ['Hematology Department, Hospital Universitari i Politècnic La Fe, 46026 Valencia, Spain'], 'affiliations': [{'raw_affiliation_string': 'Hematology Department, Hospital Universitari i Politècnic La Fe, 46026 Valencia, Spain', 'institution_ids': ['https://openalex.org/I3019010403']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038259763', 'display_name': 'Verónica Campuzano', 'orcid': 'https://orcid.org/0000-0001-7862-7055'}, 'institutions': [{'id': 'https://openalex.org/I4210115949', 'display_name': 'Hospital Universitario de Burgos', 'ror': 'https://ror.org/01j5v0d02', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210115949']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Verónica Campuzano', 'raw_affiliation_strings': ['Hematology Department, Hospital Universitario de Burgos, 09006 Burgos, Spain'], 'affiliations': [{'raw_affiliation_string': 'Hematology Department, Hospital Universitario de Burgos, 09006 Burgos, Spain', 'institution_ids': ['https://openalex.org/I4210115949']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061274629', 'display_name': 'Raquel Alcaraz', 'orcid': 'https://orcid.org/0000-0002-7501-5798'}, 'institutions': [{'id': 'https://openalex.org/I4210115949', 'display_name': 'Hospital Universitario de Burgos', 'ror': 'https://ror.org/01j5v0d02', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210115949']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Raquel Alcaraz', 'raw_affiliation_strings': ['Research Unit, Fundación Burgos por la Investigación de la Salud (FBIS), Hospital Universitario de Burgos, 09006 Burgos, Spain'], 'affiliations': [{'raw_affiliation_string': 'Research Unit, Fundación Burgos por la Investigación de la Salud (FBIS), Hospital Universitario de Burgos, 09006 Burgos, Spain', 'institution_ids': ['https://openalex.org/I4210115949']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5104021368', 'display_name': 'Isabel Cano', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I3019010403', 'display_name': 'Hospital Universitari i Politècnic La Fe', 'ror': 'https://ror.org/01ar2v535', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3019010403', 'https://openalex.org/I4210166036']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Isabel Cano', 'raw_affiliation_strings': ['Hematology Department, Hospital Universitari i Politècnic La Fe, 46026 Valencia, Spain'], 'affiliations': [{'raw_affiliation_string': 'Hematology Department, Hospital Universitari i Politècnic La Fe, 46026 Valencia, Spain', 'institution_ids': ['https://openalex.org/I3019010403']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017341923', 'display_name': 'Miguel Á. Sanz', 'orcid': 'https://orcid.org/0000-0003-1489-1177'}, 'institutions': [{'id': 'https://openalex.org/I3019010403', 'display_name': 'Hospital Universitari i Politècnic La Fe', 'ror': 'https://ror.org/01ar2v535', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3019010403', 'https://openalex.org/I4210166036']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Miguel A. Sanz', 'raw_affiliation_strings': ['Hematology Department, Hospital Universitari i Politècnic La Fe, 46026 Valencia, Spain'], 'affiliations': [{'raw_affiliation_string': 'Hematology Department, Hospital Universitari i Politècnic La Fe, 46026 Valencia, Spain', 'institution_ids': ['https://openalex.org/I3019010403']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5003682435', 'display_name': 'Pau Montesinos', 'orcid': 'https://orcid.org/0000-0002-3275-5593'}, 'institutions': [{'id': 'https://openalex.org/I3019010403', 'display_name': 'Hospital Universitari i Politècnic La Fe', 'ror': 'https://ror.org/01ar2v535', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3019010403', 'https://openalex.org/I4210166036']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Pau Montesinos', 'raw_affiliation_strings': ['Hematology Department, Hospital Universitari i Politècnic La Fe, 46026 Valencia, Spain'], 'affiliations': [{'raw_affiliation_string': 'Hematology Department, Hospital Universitari i Politècnic La Fe, 46026 Valencia, Spain', 'institution_ids': ['https://openalex.org/I3019010403']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5083903905', 'https://openalex.org/A5025193090'], 'corresponding_institution_ids': ['https://openalex.org/I4210115949', 'https://openalex.org/I46176106', 'https://openalex.org/I4210115949'], 'apc_list': {'value': 2400, 'currency': 'CHF', 'value_usd': 2598, 'provenance': 'doaj'}, 'apc_paid': {'value': 2400, 'currency': 'CHF', 'value_usd': 2598, 'provenance': 'doaj'}, 'fwci': 0.512, 'has_fulltext': False, 'cited_by_count': 10, 'citation_normalized_percentile': {'value': 0.449817, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '13', 'issue': '22', 'first_page': '5677', 'last_page': '5677'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10309', 'display_name': 'Acute Myeloid Leukemia Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10309', 'display_name': 'Acute Myeloid Leukemia Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10649', 'display_name': 'Multiple Myeloma Research and Treatments', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11736', 'display_name': 'Histone Deacetylase Inhibitors Research', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/decitabine', 'display_name': 'Decitabine', 'score': 0.97603244}, {'id': 'https://openalex.org/keywords/azacitidine', 'display_name': 'Azacitidine', 'score': 0.9750478}], 'concepts': [{'id': 'https://openalex.org/C2780235182', 'wikidata': 'https://www.wikidata.org/wiki/Q1181878', 'display_name': 'Decitabine', 'level': 5, 'score': 0.97603244}, {'id': 'https://openalex.org/C2776239401', 'wikidata': 'https://www.wikidata.org/wiki/Q416451', 'display_name': 'Azacitidine', 'level': 5, 'score': 0.9750478}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8748003}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.57664347}, {'id': 'https://openalex.org/C2778729363', 'wikidata': 'https://www.wikidata.org/wiki/Q11688946', 'display_name': 'Myeloid leukemia', 'level': 2, 'score': 0.51157147}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.44997817}, {'id': 'https://openalex.org/C190727270', 'wikidata': 'https://www.wikidata.org/wiki/Q874745', 'display_name': 'DNA methylation', 'level': 4, 'score': 0.06725758}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/cancers13225677', 'pdf_url': 'https://www.mdpi.com/2072-6694/13/22/5677/pdf?version=1637214031', 'source': {'id': 'https://openalex.org/S168415115', 'display_name': 'Cancers', 'issn_l': '2072-6694', 'issn': ['2072-6694'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8616518', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/34830832', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/cancers13225677', 'pdf_url': 'https://www.mdpi.com/2072-6694/13/22/5677/pdf?version=1637214031', 'source': {'id': 'https://openalex.org/S168415115', 'display_name': 'Cancers', 'issn_l': '2072-6694', 'issn': ['2072-6694'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.84, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 51, 'referenced_works': ['https://openalex.org/W1537972189', 'https://openalex.org/W1556454749', 'https://openalex.org/W1600365609', 'https://openalex.org/W1764888106', 'https://openalex.org/W1966327132', 'https://openalex.org/W1986993506', 'https://openalex.org/W2025667794', 'https://openalex.org/W2041356430', 'https://openalex.org/W2057051793', 'https://openalex.org/W2058188142', 'https://openalex.org/W2065268593', 'https://openalex.org/W2081391009', 'https://openalex.org/W2097035477', 'https://openalex.org/W2106084333', 'https://openalex.org/W2109895173', 'https://openalex.org/W2110893339', 'https://openalex.org/W2117954942', 'https://openalex.org/W2119148496', 'https://openalex.org/W2128168358', 'https://openalex.org/W2139033044', 'https://openalex.org/W2148660548', 'https://openalex.org/W2149058047', 'https://openalex.org/W2156098321', 'https://openalex.org/W2157287007', 'https://openalex.org/W2159738043', 'https://openalex.org/W2159792943', 'https://openalex.org/W2160968219', 'https://openalex.org/W2162700652', 'https://openalex.org/W2436188093', 'https://openalex.org/W2468996569', 'https://openalex.org/W2526458734', 'https://openalex.org/W2549790759', 'https://openalex.org/W2559537906', 'https://openalex.org/W2748257537', 'https://openalex.org/W2766970124', 'https://openalex.org/W2803589961', 'https://openalex.org/W2898284215', 'https://openalex.org/W2902869527', 'https://openalex.org/W2904032061', 'https://openalex.org/W2905325447', 'https://openalex.org/W2946108656', 'https://openalex.org/W2964697010', 'https://openalex.org/W2969217862', 'https://openalex.org/W3012563958', 'https://openalex.org/W3028372384', 'https://openalex.org/W3048827006', 'https://openalex.org/W3090882367', 'https://openalex.org/W3093265084', 'https://openalex.org/W3095201154', 'https://openalex.org/W3131481795', 'https://openalex.org/W3133019439'], 'related_works': ['https://openalex.org/W4391645188', 'https://openalex.org/W4388673960', 'https://openalex.org/W3214341925', 'https://openalex.org/W2999114056', 'https://openalex.org/W2750605634', 'https://openalex.org/W2167485228', 'https://openalex.org/W2127851369', 'https://openalex.org/W2127289529', 'https://openalex.org/W2083462343', 'https://openalex.org/W2054507167'], 'abstract_inverted_index': {'Irruption': [0], 'of': [1, 14, 43, 56, 77, 87, 91], 'decitabine': [2, 57, 106, 125, 189], 'and': [3, 51, 58, 70, 89, 124, 179, 187, 202], 'azacitidine': [4, 59, 88, 99, 118, 140, 147, 209], 'has': [5], 'led': [6], 'to': [7, 105, 159], 'profound': [8], 'changes': [9], 'in': [10, 27, 46, 61, 199, 204], 'the': [11, 39, 54, 160], 'upfront': [12], 'management': [13], 'older': [15], 'acute': [16], 'myeloid': [17], 'leukaemia': [18], '(AML).': [19], 'However,': [20], 'they': [21], 'have': [22], 'not': [23, 182], 'been': [24], 'directly': [25], 'compared': [26, 104, 158], 'a': [28, 142], 'randomised': [29], 'clinical': [30], 'trial.': [31], 'In': [32], 'addition,': [33], 'there': [34], 'are': [35], 'no': [36, 197], 'studies': [37, 72], 'comparing': [38], 'optimal': [40], 'treatment': [41], 'schedule': [42, 163], 'each': [44], 'drug': [45], 'AML.': [47], 'A': [48, 75], 'systematic': [49], 'review': [50], 'meta-analysis': [52], 'on': [53], 'efficacy': [55], 'monotherapy': [60], 'newly': [62], 'diagnosed': [63], 'AML': [64, 205], 'was': [65, 131, 148], 'conducted.': [66], 'Randomised': [67], 'controlled': [68], 'trials': [69], 'retrospective': [71], 'were': [73, 83, 96, 181], 'included.': [74], 'total': [76], '2743': [78], 'patients': [79, 173, 206], 'from': [80], '23': [81], 'cohorts': [82, 86], 'analysed': [84], '(10': [85], '13': [90], 'decitabine).': [92], 'Similar': [93], 'response': [94, 177, 200], 'rates': [95, 178, 201], 'observed': [97], 'for': [98, 150], '(38%,': [100], '95%': [101, 108, 121, 128, 155, 166], 'CI:': [102, 109, 122, 129, 156, 167], '30–47%)': [103], '(40%,': [107], '32–48%)': [110], '(p': [111, 134], '=': [112, 135, 170], '0.825).': [113], 'Overall': [114], 'survival': [115], '(OS)': [116], 'between': [117, 185, 193], '(10.04': [119], 'months,': [120, 127, 154, 165], '8.36–11.72)': [123], '(8.79': [126], '7.62–9.96)': [130], 'also': [132], 'similar': [133], '0.386).': [136], 'Patients': [137], 'treated': [138, 174, 207], 'with': [139, 175, 208], 'showed': [141], 'lower': [143], 'median': [144], 'OS': [145, 180, 203], 'when': [146], 'administered': [149], '5': [151], 'days': [152], '(6.28': [153], '4.23–8.32)': [157], 'standard': [161], '7-day': [162], '(10.83': [164], '9.07–12.59,': [168], 'p': [169], '0.002).': [171], 'Among': [172], 'decitabine,': [176], 'significantly': [183], 'different': [184], '5-day': [186], '10-day': [188], 'regimens.': [190], 'Despite': [191], 'heterogeneity': [192], 'studies,': [194], 'we': [195], 'found': [196], 'differences': [198], 'or': [210], 'decitabine.': [211]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3214341925', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 3}], 'updated_date': '2024-12-08T13:57:44.226282', 'created_date': '2021-11-22'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
