Publication Information

{'id': 'https://openalex.org/W2127851369', 'doi': 'https://doi.org/10.1080/10428190701882146', 'title': 'Activity of decitabine in patients with myelodysplastic syndrome previously treated with azacitidine', 'display_name': 'Activity of decitabine in patients with myelodysplastic syndrome previously treated with azacitidine', 'publication_year': 2008, 'publication_date': '2008-01-01', 'ids': {'openalex': 'https://openalex.org/W2127851369', 'doi': 'https://doi.org/10.1080/10428190701882146', 'mag': '2127851369', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18398735', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3702160'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/10428190701882146', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S27064115', 'display_name': 'Leukemia & lymphoma/Leukemia and lymphoma', 'issn_l': '1026-8022', 'issn': ['1026-8022', '1029-2403', '1042-8194'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc3702160?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5055045706', 'display_name': 'Gautam Borthakur', 'orcid': 'https://orcid.org/0000-0001-7679-6453'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gautam Borthakur', 'raw_affiliation_strings': ['Department of Leukemia, M.D. Anderson Cancer Center, Houston, TX, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Leukemia, M.D. Anderson Cancer Center, Houston, TX, USA.', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072223724', 'display_name': 'Samih El Ahdab', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Samih El Ahdab', 'raw_affiliation_strings': ['Department of Leukemia, M.D. Anderson Cancer Center, Houston, TX, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Leukemia, M.D. Anderson Cancer Center, Houston, TX, USA.', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000750846', 'display_name': 'Farhad Ravandi', 'orcid': 'https://orcid.org/0000-0002-7621-377X'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Farhad Ravandi', 'raw_affiliation_strings': ['Department of Leukemia, M.D. Anderson Cancer Center, Houston, TX, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Leukemia, M.D. Anderson Cancer Center, Houston, TX, USA.', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046097970', 'display_name': 'Stefan Faderl', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Stefan Faderl', 'raw_affiliation_strings': ['Department of Leukemia, M.D. Anderson Cancer Center, Houston, TX, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Leukemia, M.D. Anderson Cancer Center, Houston, TX, USA.', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028845635', 'display_name': 'Alessandra Ferrajoli', 'orcid': 'https://orcid.org/0000-0001-9547-4193'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alessandra Ferrajoli', 'raw_affiliation_strings': ['Department of Leukemia, M.D. Anderson Cancer Center, Houston, TX, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Leukemia, M.D. Anderson Cancer Center, Houston, TX, USA.', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002417102', 'display_name': 'Beth Newman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Beth Newman', 'raw_affiliation_strings': ['Department of Leukemia, M.D. Anderson Cancer Center, Houston, TX, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Leukemia, M.D. Anderson Cancer Center, Houston, TX, USA.', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062330946', 'display_name': 'Jean‐Pierre J. Issa', 'orcid': 'https://orcid.org/0000-0003-2258-5030'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jean-Pierre Issa', 'raw_affiliation_strings': ['Department of Leukemia, M.D. Anderson Cancer Center, Houston, TX, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Leukemia, M.D. Anderson Cancer Center, Houston, TX, USA.', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5090435894', 'display_name': 'Hagop M. Kantarjian', 'orcid': 'https://orcid.org/0000-0002-1908-3307'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hagop Kantarjian', 'raw_affiliation_strings': ['Department of Leukemia, M.D. Anderson Cancer Center, Houston, TX, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Leukemia, M.D. Anderson Cancer Center, Houston, TX, USA.', 'institution_ids': ['https://openalex.org/I1343551460']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 5.901, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 99, 'citation_normalized_percentile': {'value': 0.999838, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '49', 'issue': '4', 'first_page': '690', 'last_page': '695'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10309', 'display_name': 'Acute Myeloid Leukemia Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10309', 'display_name': 'Acute Myeloid Leukemia Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12369', 'display_name': 'Pneumocystis jirovecii pneumonia detection and treatment', 'score': 0.9978, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9941, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/azacitidine', 'display_name': 'Azacitidine', 'score': 0.9799096}, {'id': 'https://openalex.org/keywords/decitabine', 'display_name': 'Decitabine', 'score': 0.97865885}, {'id': 'https://openalex.org/keywords/hypomethylating-agent', 'display_name': 'Hypomethylating agent', 'score': 0.71333116}], 'concepts': [{'id': 'https://openalex.org/C2776239401', 'wikidata': 'https://www.wikidata.org/wiki/Q416451', 'display_name': 'Azacitidine', 'level': 5, 'score': 0.9799096}, {'id': 'https://openalex.org/C2780235182', 'wikidata': 'https://www.wikidata.org/wiki/Q1181878', 'display_name': 'Decitabine', 'level': 5, 'score': 0.97865885}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.82384264}, {'id': 'https://openalex.org/C2780817109', 'wikidata': 'https://www.wikidata.org/wiki/Q954625', 'display_name': 'Myelodysplastic syndromes', 'level': 3, 'score': 0.7448485}, {'id': 'https://openalex.org/C2776012956', 'wikidata': 'https://www.wikidata.org/wiki/Q17125294', 'display_name': 'Hypomethylating agent', 'level': 5, 'score': 0.71333116}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5771088}, {'id': 'https://openalex.org/C29730261', 'wikidata': 'https://www.wikidata.org/wiki/Q274160', 'display_name': 'Toxicity', 'level': 2, 'score': 0.48996225}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.42950884}, {'id': 'https://openalex.org/C190727270', 'wikidata': 'https://www.wikidata.org/wiki/Q874745', 'display_name': 'DNA methylation', 'level': 4, 'score': 0.19384342}, {'id': 'https://openalex.org/C2780007613', 'wikidata': 'https://www.wikidata.org/wiki/Q546523', 'display_name': 'Bone marrow', 'level': 2, 'score': 0.14282605}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001374', 'descriptor_name': 'Azacitidine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D001374', 'descriptor_name': 'Azacitidine', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D009190', 'descriptor_name': 'Myelodysplastic Syndromes', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D016879', 'descriptor_name': 'Salvage Therapy', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001374', 'descriptor_name': 'Azacitidine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001374', 'descriptor_name': 'Azacitidine', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D019175', 'descriptor_name': 'DNA Methylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019175', 'descriptor_name': 'DNA Methylation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D000077209', 'descriptor_name': 'Decitabine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009190', 'descriptor_name': 'Myelodysplastic Syndromes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016879', 'descriptor_name': 'Salvage Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017211', 'descriptor_name': 'Treatment Failure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/10428190701882146', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S27064115', 'display_name': 'Leukemia & lymphoma/Leukemia and lymphoma', 'issn_l': '1026-8022', 'issn': ['1026-8022', '1029-2403', '1042-8194'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3702160', 'pdf_url': 'https://europepmc.org/articles/pmc3702160?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702160', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/18398735', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3702160', 'pdf_url': 'https://europepmc.org/articles/pmc3702160?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.75, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 19, 'referenced_works': ['https://openalex.org/W1528346173', 'https://openalex.org/W1541216017', 'https://openalex.org/W187238933', 'https://openalex.org/W1968263601', 'https://openalex.org/W1987152779', 'https://openalex.org/W2022240113', 'https://openalex.org/W2029595590', 'https://openalex.org/W2081279521', 'https://openalex.org/W2106401558', 'https://openalex.org/W2106584820', 'https://openalex.org/W2109895173', 'https://openalex.org/W2118119661', 'https://openalex.org/W2121710010', 'https://openalex.org/W2129510594', 'https://openalex.org/W2140908643', 'https://openalex.org/W2147083172', 'https://openalex.org/W2159507916', 'https://openalex.org/W2181468201', 'https://openalex.org/W2337125650'], 'related_works': ['https://openalex.org/W4286817035', 'https://openalex.org/W3203236595', 'https://openalex.org/W3157575545', 'https://openalex.org/W2409251897', 'https://openalex.org/W2189342016', 'https://openalex.org/W2167485228', 'https://openalex.org/W2054507167', 'https://openalex.org/W2051650123', 'https://openalex.org/W1983754555', 'https://openalex.org/W1974512900'], 'abstract_inverted_index': {'Azacitidine': [0], 'and': [1, 12, 54, 82, 122], 'decitabine': [2, 131], 'are': [3], 'the': [4, 10, 16, 31, 68], 'two': [5, 78], 'hypomethylating': [6], 'agents': [7], 'approved': [8], 'by': [9], 'Food': [11], 'Drug': [13], 'Administration': [14], 'for': [15, 60, 79, 84], 'treatment': [17, 106], 'of': [18, 26, 30, 41, 65, 103], 'patients': [19, 36, 49, 136], 'with': [20, 37, 45, 107, 130], 'myelodysplastic': [21], 'syndrome': [22], '(MDS).': [23], 'The': [24], 'efficacy': [25], 'one': [27, 55, 70, 83], 'agent': [28], 'post-failure': [29], 'other': [32], 'is': [33], 'unknown.': [34], 'Fourteen': [35], 'MDS': [38], 'post-azacitidine': [39, 137], 'failure/lack': [40], 'response/intolerance': [42], 'were': [43, 93], 'treated': [44], 'decitabine.': [46, 108], 'Overall': [47], 'three': [48], 'achieved': [50], 'a': [51], 'complete': [52], 'remission,': [53], 'patient': [56, 99], 'had': [57], 'hematologic': [58], 'improvement,': [59], 'an': [61], 'overall': [62], 'response': [63, 81], 'rate': [64], '28%.': [66], 'Of': [67], 'responders,': [69], 'stopped': [71], 'prior': [72], '5-azacitidine': [73], 'owing': [74], 'to': [75], 'disease': [76], 'progression,': [77], 'no': [80, 116], 'severe': [85], 'skin': [86], 'toxicity.': [87, 141], 'Grade': [88], '3-4': [89], 'drug': [90], 'related': [91], 'side-effects': [92], 'minimal.': [94], 'Global': [95], 'methylation': [96, 104], 'studies': [97], 'in': [98, 110, 118, 135], 'samples': [100], 'showed': [101], 'decrease': [102], 'after': [105], 'As': [109], 'our': [111], 'previous': [112], 'studies,': [113], 'there': [114], 'was': [115], 'difference': [117], 'hypomethylation': [119], 'between': [120], 'responders': [121], 'nonresponders.': [123], 'We': [124], 'conclude': [125], 'that': [126], 'clinically': [127], 'significant': [128, 140], 'responses': [129], 'can': [132], 'be': [133], 'seen': [134], 'failure': [138], 'without': [139]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2127851369', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 12}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-08T06:58:21.412943', 'created_date': '2016-06-24'}