Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2335896793', 'doi': 'https://doi.org/10.1073/pnas.1522612113', 'title': 'NF-κB–driven suppression of FOXO3a contributes to EGFR mutation-independent gefitinib resistance', 'display_name': 'NF-κB–driven suppression of FOXO3a contributes to EGFR mutation-independent gefitinib resistance', 'publication_year': 2016, 'publication_date': '2016-04-18', 'ids': {'openalex': 'https://openalex.org/W2335896793', 'doi': 'https://doi.org/10.1073/pnas.1522612113', 'mag': '2335896793', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/27091996', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4983816'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.1522612113', 'pdf_url': 'https://www.pnas.org/content/pnas/113/18/E2526.full.pdf', 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.pnas.org/content/pnas/113/18/E2526.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5054499877', 'display_name': 'Ching‐Feng Chiu', 'orcid': 'https://orcid.org/0000-0001-5591-0288'}, 'institutions': [{'id': 'https://openalex.org/I165441096', 'display_name': 'National Health Research Institutes', 'ror': 'https://ror.org/02r6fpx29', 'country_code': 'TW', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I165441096']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Ching-Feng Chiu', 'raw_affiliation_strings': ['National Institute of Cancer Research, National Health Research Institutes, Miaoli County 35053, Taiwan;'], 'affiliations': [{'raw_affiliation_string': 'National Institute of Cancer Research, National Health Research Institutes, Miaoli County 35053, Taiwan;', 'institution_ids': ['https://openalex.org/I165441096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109334202', 'display_name': 'Yi-Wen Chang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I165441096', 'display_name': 'National Health Research Institutes', 'ror': 'https://ror.org/02r6fpx29', 'country_code': 'TW', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I165441096']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Yi-Wen Chang', 'raw_affiliation_strings': ['National Institute of Cancer Research, National Health Research Institutes, Miaoli County 35053, Taiwan;'], 'affiliations': [{'raw_affiliation_string': 'National Institute of Cancer Research, National Health Research Institutes, Miaoli County 35053, Taiwan;', 'institution_ids': ['https://openalex.org/I165441096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058391280', 'display_name': 'Kuang-Tai Kuo', 'orcid': 'https://orcid.org/0000-0003-2754-2283'}, 'institutions': [{'id': 'https://openalex.org/I4210158385', 'display_name': 'Taipei Medical University-Shuang Ho Hospital', 'ror': 'https://ror.org/04k9dce70', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210158385']}, {'id': 'https://openalex.org/I47519274', 'display_name': 'Taipei Medical University', 'ror': 'https://ror.org/05031qk94', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I47519274']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Kuang-Tai Kuo', 'raw_affiliation_strings': ['Division of Thoracic Surgery, Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei City 110, Taiwan;', 'Division of Thoracic Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan;'], 'affiliations': [{'raw_affiliation_string': 'Division of Thoracic Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan;', 'institution_ids': ['https://openalex.org/I4210158385']}, {'raw_affiliation_string': 'Division of Thoracic Surgery, Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei City 110, Taiwan;', 'institution_ids': ['https://openalex.org/I47519274']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088451575', 'display_name': 'Yu-Shiuan Shen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I143578492', 'display_name': 'Asia University', 'ror': 'https://ror.org/038a1tp19', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I143578492']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Yu-Shiuan Shen', 'raw_affiliation_strings': ['Department of Biotechnology, Asia University, Taichung City 413, Taiwan;'], 'affiliations': [{'raw_affiliation_string': 'Department of Biotechnology, Asia University, Taichung City 413, Taiwan;', 'institution_ids': ['https://openalex.org/I143578492']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019379554', 'display_name': 'Chien‐Ying Liu', 'orcid': 'https://orcid.org/0000-0002-8521-3456'}, 'institutions': [{'id': 'https://openalex.org/I3020100970', 'display_name': 'Chang Gung Memorial Hospital', 'ror': 'https://ror.org/02verss31', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I3020100970']}, {'id': 'https://openalex.org/I173093425', 'display_name': 'Chang Gung University', 'ror': 'https://ror.org/00d80zx46', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I173093425']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Chien-Ying Liu', 'raw_affiliation_strings': ['Division of Pulmonary Oncology and Interventional Bronchoscopy, Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taoyuan City 33305, Taiwan;', 'School of Medicine, Chang Gung University, Taoyuan City 33305, Taiwan;'], 'affiliations': [{'raw_affiliation_string': 'Division of Pulmonary Oncology and Interventional Bronchoscopy, Department of Thoracic Medicine, Chang Gung Memorial Hospital, Taoyuan City 33305, Taiwan;', 'institution_ids': ['https://openalex.org/I3020100970']}, {'raw_affiliation_string': 'School of Medicine, Chang Gung University, Taoyuan City 33305, Taiwan;', 'institution_ids': ['https://openalex.org/I173093425']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049315419', 'display_name': 'Yang‐Hao Yu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210126829', 'display_name': 'China Medical University Hospital', 'ror': 'https://ror.org/0368s4g32', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126829']}, {'id': 'https://openalex.org/I184693016', 'display_name': 'China Medical University', 'ror': 'https://ror.org/00v408z34', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I184693016']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Yang-Hao Yu', 'raw_affiliation_strings': ['Divisions of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung City 404, Taiwan;', 'School of Medicine, China Medical University, Taichung City 404, Taiwan;'], 'affiliations': [{'raw_affiliation_string': 'Divisions of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung City 404, Taiwan;', 'institution_ids': ['https://openalex.org/I4210126829', 'https://openalex.org/I184693016']}, {'raw_affiliation_string': 'School of Medicine, China Medical University, Taichung City 404, Taiwan;', 'institution_ids': ['https://openalex.org/I184693016']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5107479051', 'display_name': 'Ching-Chia Cheng', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I165441096', 'display_name': 'National Health Research Institutes', 'ror': 'https://ror.org/02r6fpx29', 'country_code': 'TW', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I165441096']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Ching-Chia Cheng', 'raw_affiliation_strings': ['National Institute of Cancer Research, National Health Research Institutes, Miaoli County 35053, Taiwan;'], 'affiliations': [{'raw_affiliation_string': 'National Institute of Cancer Research, National Health Research Institutes, Miaoli County 35053, Taiwan;', 'institution_ids': ['https://openalex.org/I165441096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5107934899', 'display_name': 'Kang‐Yun Lee', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I47519274', 'display_name': 'Taipei Medical University', 'ror': 'https://ror.org/05031qk94', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I47519274']}, {'id': 'https://openalex.org/I4210158385', 'display_name': 'Taipei Medical University-Shuang Ho Hospital', 'ror': 'https://ror.org/04k9dce70', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210158385']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Kang-Yun Lee', 'raw_affiliation_strings': ['Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei City 110, Taiwan;', 'Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan;'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei City 110, Taiwan;', 'institution_ids': ['https://openalex.org/I47519274']}, {'raw_affiliation_string': 'Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan;', 'institution_ids': ['https://openalex.org/I4210158385']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054373289', 'display_name': 'Feng‐Chi Chen', 'orcid': 'https://orcid.org/0000-0002-1437-4420'}, 'institutions': [{'id': 'https://openalex.org/I165441096', 'display_name': 'National Health Research Institutes', 'ror': 'https://ror.org/02r6fpx29', 'country_code': 'TW', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I165441096']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Feng-Chi Chen', 'raw_affiliation_strings': ['Institute of Population Health Sciences, National Health Research Institutes, Miaoli County 35053, Taiwan;'], 'affiliations': [{'raw_affiliation_string': 'Institute of Population Health Sciences, National Health Research Institutes, Miaoli County 35053, Taiwan;', 'institution_ids': ['https://openalex.org/I165441096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066586451', 'display_name': 'Min-Kung Hsu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I148366613', 'display_name': 'National Yang Ming Chiao Tung University', 'ror': 'https://ror.org/00se2k293', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I148366613']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Min-Kung Hsu', 'raw_affiliation_strings': ['Department of Biological Science and Technology, National Chiao Tung University, Hsinchu City 300, Taiwan;'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Science and Technology, National Chiao Tung University, Hsinchu City 300, Taiwan;', 'institution_ids': ['https://openalex.org/I148366613']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037168708', 'display_name': 'Tsang‐Chih Kuo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I16733864', 'display_name': 'National Taiwan University', 'ror': 'https://ror.org/05bqach95', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I16733864']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Tsang-Chih Kuo', 'raw_affiliation_strings': ['Institute of Biochemical Sciences, College of Life Science, National Taiwan University, Taipei City 10617, Taiwan;'], 'affiliations': [{'raw_affiliation_string': 'Institute of Biochemical Sciences, College of Life Science, National Taiwan University, Taipei City 10617, Taiwan;', 'institution_ids': ['https://openalex.org/I16733864']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063190209', 'display_name': 'Jui‐Ti Ma', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I165441096', 'display_name': 'National Health Research Institutes', 'ror': 'https://ror.org/02r6fpx29', 'country_code': 'TW', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I165441096']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Jui-Ti Ma', 'raw_affiliation_strings': ['National Institute of Cancer Research, National Health Research Institutes, Miaoli County 35053, Taiwan;'], 'affiliations': [{'raw_affiliation_string': 'National Institute of Cancer Research, National Health Research Institutes, Miaoli County 35053, Taiwan;', 'institution_ids': ['https://openalex.org/I165441096']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5112905008', 'display_name': 'Jen-Liang Su', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I165441096', 'display_name': 'National Health Research Institutes', 'ror': 'https://ror.org/02r6fpx29', 'country_code': 'TW', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I165441096']}, {'id': 'https://openalex.org/I143578492', 'display_name': 'Asia University', 'ror': 'https://ror.org/038a1tp19', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I143578492']}, {'id': 'https://openalex.org/I184693016', 'display_name': 'China Medical University', 'ror': 'https://ror.org/00v408z34', 'country_code': 'TW', 'type': 'education', 'lineage': ['https://openalex.org/I184693016']}, {'id': 'https://openalex.org/I4210126829', 'display_name': 'China Medical University Hospital', 'ror': 'https://ror.org/0368s4g32', 'country_code': 'TW', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126829']}], 'countries': ['TW'], 'is_corresponding': False, 'raw_author_name': 'Jen-Liang Su', 'raw_affiliation_strings': ['Center for Molecular Medicine, China Medical University Hospital, Taichung City 404, Taiwan', 'Department of Biotechnology, Asia University, Taichung City 413, Taiwan;', 'Graduate Institute of Cancer Biology, China Medical University, Taichung City 404, Taiwan;', 'National Institute of Cancer Research, National Health Research Institutes, Miaoli County 35053, Taiwan;'], 'affiliations': [{'raw_affiliation_string': 'National Institute of Cancer Research, National Health Research Institutes, Miaoli County 35053, Taiwan;', 'institution_ids': ['https://openalex.org/I165441096']}, {'raw_affiliation_string': 'Department of Biotechnology, Asia University, Taichung City 413, Taiwan;', 'institution_ids': ['https://openalex.org/I143578492']}, {'raw_affiliation_string': 'Graduate Institute of Cancer Biology, China Medical University, Taichung City 404, Taiwan;', 'institution_ids': ['https://openalex.org/I184693016']}, {'raw_affiliation_string': 'Center for Molecular Medicine, China Medical University Hospital, Taichung City 404, Taiwan', 'institution_ids': ['https://openalex.org/I184693016', 'https://openalex.org/I4210126829']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 10, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 4.75, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 75, 'citation_normalized_percentile': {'value': 0.999984, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '113', 'issue': '18', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12835', 'display_name': 'FOXO transcription factor regulation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12835', 'display_name': 'FOXO transcription factor regulation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13779', 'display_name': 'Cancer Mechanisms and Therapy', 'score': 0.994, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10062', 'display_name': 'MicroRNA in disease regulation', 'score': 0.9835, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/erlotinib-hydrochloride', 'display_name': 'Erlotinib Hydrochloride', 'score': 0.44207895}], 'concepts': [{'id': 'https://openalex.org/C2780580887', 'wikidata': 'https://www.wikidata.org/wiki/Q417824', 'display_name': 'Gefitinib', 'level': 4, 'score': 0.98041904}, {'id': 'https://openalex.org/C2778087573', 'wikidata': 'https://www.wikidata.org/wiki/Q418369', 'display_name': 'Erlotinib', 'level': 4, 'score': 0.78881395}, {'id': 'https://openalex.org/C2776256026', 'wikidata': 'https://www.wikidata.org/wiki/Q47912', 'display_name': 'Lung cancer', 'level': 2, 'score': 0.72920763}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.6891767}, {'id': 'https://openalex.org/C2779438470', 'wikidata': 'https://www.wikidata.org/wiki/Q424401', 'display_name': 'Epidermal growth factor receptor', 'level': 3, 'score': 0.66989416}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.489978}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.47825682}, {'id': 'https://openalex.org/C2909325608', 'wikidata': 'https://www.wikidata.org/wiki/Q418369', 'display_name': 'Erlotinib Hydrochloride', 'level': 5, 'score': 0.44207895}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.36842835}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.29109287}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.2720878}], 'mesh': [{'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000071316', 'descriptor_name': 'Forkhead Box Protein O3', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016328', 'descriptor_name': 'NF-kappa B', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011799', 'descriptor_name': 'Quinazolines', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D066246', 'descriptor_name': 'ErbB Receptors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071316', 'descriptor_name': 'Forkhead Box Protein O3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077156', 'descriptor_name': 'Gefitinib', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016328', 'descriptor_name': 'NF-kappa B', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011799', 'descriptor_name': 'Quinazolines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.1522612113', 'pdf_url': 'https://www.pnas.org/content/pnas/113/18/E2526.full.pdf', 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4983816', 'pdf_url': 'https://europepmc.org/articles/pmc4983816?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983816', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/27091996', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.1522612113', 'pdf_url': 'https://www.pnas.org/content/pnas/113/18/E2526.full.pdf', 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.86}], 'grants': [{'funder': 'https://openalex.org/F4320322795', 'funder_display_name': 'Ministry of Science and Technology, Taiwan', 'award_id': '101-2320-B-400-016-MY3'}, {'funder': 'https://openalex.org/F4320322795', 'funder_display_name': 'Ministry of Science and Technology, Taiwan', 'award_id': '103-2314-B-038-059'}, {'funder': 'https://openalex.org/F4320322795', 'funder_display_name': 'Ministry of Science and Technology, Taiwan', 'award_id': '104-2320-B-400-015-MY3'}, {'funder': 'https://openalex.org/F4320322795', 'funder_display_name': 'Ministry of Science and Technology, Taiwan', 'award_id': '102-2314-B-038-028-MY3'}, {'funder': 'https://openalex.org/F4320322845', 'funder_display_name': 'National Health Research Institutes', 'award_id': 'CA-103-PP-35'}, {'funder': 'https://openalex.org/F4320322845', 'funder_display_name': 'National Health Research Institutes', 'award_id': 'MOHW104-TDU-B-212-124-008'}, {'funder': 'https://openalex.org/F4320322845', 'funder_display_name': 'National Health Research Institutes', 'award_id': 'CA-105-PP-12'}, {'funder': 'https://openalex.org/F4320322845', 'funder_display_name': 'National Health Research Institutes', 'award_id': 'CA-102-PP-41'}, {'funder': 'https://openalex.org/F4320322845', 'funder_display_name': 'National Health Research Institutes', 'award_id': 'CA-104-PP-12'}], 'datasets': [], 'versions': [], 'referenced_works_count': 51, 'referenced_works': ['https://openalex.org/W1594203091', 'https://openalex.org/W1919718700', 'https://openalex.org/W1965710516', 'https://openalex.org/W1966828006', 'https://openalex.org/W1967394241', 'https://openalex.org/W1970685293', 'https://openalex.org/W1972896630', 'https://openalex.org/W1974198249', 'https://openalex.org/W1983357205', 'https://openalex.org/W1986907203', 'https://openalex.org/W1991084052', 'https://openalex.org/W2019607817', 'https://openalex.org/W2029218729', 'https://openalex.org/W2031285399', 'https://openalex.org/W2032550506', 'https://openalex.org/W2032630075', 'https://openalex.org/W2034201098', 'https://openalex.org/W2035704783', 'https://openalex.org/W2041869770', 'https://openalex.org/W2042108179', 'https://openalex.org/W2044509984', 'https://openalex.org/W2045476312', 'https://openalex.org/W2051488121', 'https://openalex.org/W2055579579', 'https://openalex.org/W2058822154', 'https://openalex.org/W2076046722', 'https://openalex.org/W2081730209', 'https://openalex.org/W2083837182', 'https://openalex.org/W2087955215', 'https://openalex.org/W2091134276', 'https://openalex.org/W2094057765', 'https://openalex.org/W2094205550', 'https://openalex.org/W2098208011', 'https://openalex.org/W2098395191', 'https://openalex.org/W2110354540', 'https://openalex.org/W2110935705', 'https://openalex.org/W2114570899', 'https://openalex.org/W2117986690', 'https://openalex.org/W2132157071', 'https://openalex.org/W2134029343', 'https://openalex.org/W2137035181', 'https://openalex.org/W2139959086', 'https://openalex.org/W2143913849', 'https://openalex.org/W2152636515', 'https://openalex.org/W2158158246', 'https://openalex.org/W2158386218', 'https://openalex.org/W2160921084', 'https://openalex.org/W2161821474', 'https://openalex.org/W2168854899', 'https://openalex.org/W2169532116', 'https://openalex.org/W2171981784'], 'related_works': ['https://openalex.org/W3147989365', 'https://openalex.org/W2575565717', 'https://openalex.org/W2557772662', 'https://openalex.org/W2254126652', 'https://openalex.org/W2168841302', 'https://openalex.org/W2154670277', 'https://openalex.org/W2154226624', 'https://openalex.org/W2142865455', 'https://openalex.org/W2088932689', 'https://openalex.org/W2028069016'], 'abstract_inverted_index': {'Significance': [0], 'Gefitinib': [1], 'is': [2, 59], 'a': [3, 18, 51, 104], 'small': [4], 'molecular': [5], 'inhibitor': [6], 'that': [7, 56], 'targets': [8], 'EGFR': [9, 80], 'tyrosine': [10], 'kinases': [11], '(EGFR-TKI)': [12], 'and': [13, 35, 72, 84], 'has': [14, 39], 'been': [15, 40], 'used': [16], 'as': [17, 103], 'first-line': [19], 'treatment': [20, 49, 71], 'for': [21, 42, 50, 108], 'advanced': [22], 'lung': [23, 28, 43, 63, 109], 'cancer.': [24], 'However,': [25], 'not': [26], 'all': [27], 'cancer': [29, 44, 64, 82, 110], 'patients': [30, 45, 65], 'respond': [31], 'to': [32, 37, 69, 116], 'gefitinib': [33, 38, 85], 'treatment,': [34], 'resistance': [36, 86, 115], 'apparent': [41], 'who': [46, 66], 'have': [47], 'undergone': [48], 'few': [52], 'months.': [53], 'We': [54], 'observed': [55], 'FOXO3a': [57, 78], 'expression': [58], 'inversely': [60], 'correlated': [61], 'with': [62, 111], 'responded': [67], 'poorly': [68], 'EGFR-TKI': [70], 'identified': [73], 'an': [74], 'underlying': [75], 'mechanism': [76], 'of': [77, 91, 98, 114], 'in': [79], 'mutation-independent': [81], 'stemness': [83], 'through': [87], 'the': [88, 96, 100, 112], 'epigenetic': [89], 'regulation': [90], 'NF-κB/miR-155.': [92], 'This': [93], 'finding': [94], 'highlights': [95], 'potential': [97], 'targeting': [99], 'NF-κB/miR-155/FOXO3a': [101], 'pathway': [102], 'novel': [105], 'therapeutic': [106], 'strategy': [107], 'acquisition': [113], 'EGFR-TKIs.': [117]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2335896793', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 12}, {'year': 2018, 'cited_by_count': 14}, {'year': 2017, 'cited_by_count': 9}, {'year': 2016, 'cited_by_count': 5}], 'updated_date': '2025-01-06T07:10:41.260411', 'created_date': '2016-06-24'}