Title: DEPRESSION OF ERYTHROPOIESIS BY LOCAL IRRADIATION OF THE SPLEEN: EXPERIMENTAL STUDY IN THE RABBIT WITH THE AID OF Fe$sup 5$$sup 9$
Abstract:Bone marrow function was followed in rabbits after 300-r x irradiation of the exteriorized spleen. The function was evaluated by reticulocyte counts and the rate of removal of injected Fe/sup 59/ from...Bone marrow function was followed in rabbits after 300-r x irradiation of the exteriorized spleen. The function was evaluated by reticulocyte counts and the rate of removal of injected Fe/sup 59/ from plasma. Precisely 48 hr after splenic irradiation with 300 r, the circulating reticulocyte count fell sharply to less than 1% as compared wlth 2.5% in controls. The low count persisted for 24to 36 hr, and was followed by a rise in the count to above normal levels for about 2 days until the normal level was regained. The changes in reticulocythemia were not seen if the spleen was removed after or before irradiation. In contrast, 500-r whole-body irradiation caused a fall in the count within 36 hr to below 1%, wlth no rebound. The half time for the disappearance of injected Fe/sup 59/ from plasma was not different from the control value of 80 min when the injection was made immediately after splenic irradiation. However, it was increased to st run. Concent 125 min when Fe/sup 59/ was injected 60 hr afterwards and st run. Concent 230 min when Fe/sup 59/ was injected 48 hr after 500-r whole-body irradiation. The rapid, reversible depression of erythopoiesis after splenic irradiationmore » suggests that the irradiated spleen releases a factor, possibly humoral, which inhiblts maturation of bone marrow cells. (TCO)« lessRead More
Publication Year: 1962
Publication Date: 1962-10-20
Language: en
Type: article
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