Title: Evaluation of Erythropoietic Damage and Recuperation Following X-irradiation
Abstract:It has been shown that the total uptake of Fe59 following X-irradiation is dependent not only upon the irradiation dose received, but also upon the time of isotope injection. When animals are injected...It has been shown that the total uptake of Fe59 following X-irradiation is dependent not only upon the irradiation dose received, but also upon the time of isotope injection. When animals are injected 24 hr after X-irradiation, they show, for all X-ray dose levels studied, decreased uptake of the Fe59 both at 1 day following injection and at 2 weeks postinjection. However, when the injection of radioiron is done at 5 days post-irradiation, there is no significant depression at the same sampling periods for irradiation doses of 300r or less. In addition, it was noted that the general shape of the uptake vs. X-ray dose curve at 14 days after injection closely paralleled the curve obtained when sampling was done 1 day' after injection. The only significant difference in this case being that the total uptake at 14 days was consistently greater than at 1 day, as might be expected. Comparison of the curves for the 24-hr injection with the fifth day injection curves demonstrated that radioiron uptake following injection at 5 days could not be predicted from the data obtained from a 24-hr injection, and vice versa. It was also found, in both cases, that when the first injection was followed by a second 17 days later, the uptake curves of the two injections showed a marked divergence up to the point of lethal irradiation dosages. At or near the point of lethal X-ray dosage the curve from the second injection showed a marked change in slope culminating in noticeably lower Fe59 uptake. While giving no absolute index of the total physical X-ray dose administered, this latter phenomenum could be utilized to give an approximate indication of both the amount of irradiation received and the ability of the individual animal to recover.Read More
Publication Year: 1964
Publication Date: 1964-02-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 3
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