Title: Anti-convulsant activity of methanolic extract of Butea monosperma leaves
Abstract:The Anticonvulsant activity of methanolic extract of leaves of Butea monosperma (100,200,400mg/kg;p.o) was assessed by using Maximal Electroshock seizure(MES), Pentylenetetrazole (80mg/kg;s.c) and Str...The Anticonvulsant activity of methanolic extract of leaves of Butea monosperma (100,200,400mg/kg;p.o) was assessed by using Maximal Electroshock seizure(MES), Pentylenetetrazole (80mg/kg;s.c) and Strychnine(4mg/kg;i.m) induced seizures in mice.The extract significantly delayed the onset of convulsions induced by Pentylenetetrazole(PTZ) and Maximal Electroshock seizure(MES) in a dose dependent manner. Anticonvulsant effect of the extract was comparable to clinically used antiepileptic drugs (Diazepam). But, the extract did not protect the Strychnine induced seizure at significant level even in the dose of 400mg/kg;p.o. These results suggest that the extract of Butea monosperma leaves possess anticonvulsant activity against Maximal Electroshock and Pentylenetetrazole induced seizure. The extract could have exhibited the activity by interfering with GABA, glutamatergic mechanism.Read More
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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Cited By Count: 13
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