Publication Information

{'id': 'https://openalex.org/W2186552112', 'doi': None, 'title': 'Review Article Topoisomerase II Inhibitors in Cancer Treatment', 'display_name': 'Review Article Topoisomerase II Inhibitors in Cancer Treatment', 'publication_year': 2011, 'publication_date': '2011-01-01', 'ids': {'openalex': 'https://openalex.org/W2186552112', 'mag': '2186552112'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'http://www.ijpsnonline.com/Issues/1173_full.pdf', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': [], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5111370679', 'display_name': 'Devendra Thakur', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': True, 'raw_author_name': 'Devendra Singh Thakur', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 0, 'institutions_distinct_count': 0, 'corresponding_author_ids': ['https://openalex.org/A5111370679'], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 65}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12356', 'display_name': 'Bioactive Compounds and Antitumor Agents', 'score': 0.9813, 'subfield': {'id': 'https://openalex.org/subfields/3005', 'display_name': 'Toxicology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13188', 'display_name': 'Synthesis and bioactivity of alkaloids', 'score': 0.9746, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/topoisomerase-inhibitor', 'display_name': 'Topoisomerase inhibitor', 'score': 0.63799715}, {'id': 'https://openalex.org/keywords/teniposide', 'display_name': 'Teniposide', 'score': 0.6311419}, {'id': 'https://openalex.org/keywords/daunorubicin', 'display_name': 'Daunorubicin', 'score': 0.49632674}], 'concepts': [{'id': 'https://openalex.org/C147897179', 'wikidata': 'https://www.wikidata.org/wiki/Q407828', 'display_name': 'Topoisomerase', 'level': 3, 'score': 0.9385191}, {'id': 'https://openalex.org/C2778119113', 'wikidata': 'https://www.wikidata.org/wiki/Q418817', 'display_name': 'Etoposide', 'level': 3, 'score': 0.8331231}, {'id': 'https://openalex.org/C2778616834', 'wikidata': 'https://www.wikidata.org/wiki/Q281044', 'display_name': 'Topoisomerase inhibitor', 'level': 4, 'score': 0.63799715}, {'id': 'https://openalex.org/C2778707968', 'wikidata': 'https://www.wikidata.org/wiki/Q417555', 'display_name': 'Teniposide', 'level': 4, 'score': 0.6311419}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.5937742}, {'id': 'https://openalex.org/C2781021840', 'wikidata': 'https://www.wikidata.org/wiki/Q411659', 'display_name': 'Daunorubicin', 'level': 3, 'score': 0.49632674}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.47996736}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4674208}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.40399504}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.3537929}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.19862509}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.13063875}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'http://www.ijpsnonline.com/Issues/1173_full.pdf', 'pdf_url': None, 'source': None, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.8, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 55, 'referenced_works': ['https://openalex.org/W121240503', 'https://openalex.org/W1491023198', 'https://openalex.org/W1533405440', 'https://openalex.org/W1587615774', 'https://openalex.org/W1597583171', 'https://openalex.org/W1670988858', 'https://openalex.org/W1779964374', 'https://openalex.org/W1847176704', 'https://openalex.org/W1971566084', 'https://openalex.org/W1973179542', 'https://openalex.org/W1979146479', 'https://openalex.org/W1980303697', 'https://openalex.org/W2000131597', 'https://openalex.org/W2002297333', 'https://openalex.org/W2003751313', 'https://openalex.org/W2017617555', 'https://openalex.org/W2024322753', 'https://openalex.org/W2027522177', 'https://openalex.org/W2039444414', 'https://openalex.org/W2049025695', 'https://openalex.org/W2050888120', 'https://openalex.org/W2051907464', 'https://openalex.org/W2053672030', 'https://openalex.org/W2055948074', 'https://openalex.org/W2061105502', 'https://openalex.org/W2065447230', 'https://openalex.org/W2078244781', 'https://openalex.org/W2082876519', 'https://openalex.org/W2083548496', 'https://openalex.org/W2087847676', 'https://openalex.org/W2090511435', 'https://openalex.org/W2092415563', 'https://openalex.org/W2093574265', 'https://openalex.org/W2094570498', 'https://openalex.org/W2102345056', 'https://openalex.org/W2103489107', 'https://openalex.org/W2110496778', 'https://openalex.org/W2116968980', 'https://openalex.org/W2119861722', 'https://openalex.org/W2122696814', 'https://openalex.org/W2124013844', 'https://openalex.org/W2135222446', 'https://openalex.org/W2139716252', 'https://openalex.org/W2147092104', 'https://openalex.org/W2156567288', 'https://openalex.org/W2160893557', 'https://openalex.org/W2171177278', 'https://openalex.org/W2171319481', 'https://openalex.org/W2318091958', 'https://openalex.org/W2320919288', 'https://openalex.org/W2328379078', 'https://openalex.org/W2406125082', 'https://openalex.org/W2428578210', 'https://openalex.org/W2440063679', 'https://openalex.org/W2885877184'], 'related_works': ['https://openalex.org/W3152458788', 'https://openalex.org/W3081451859', 'https://openalex.org/W2870769047', 'https://openalex.org/W2592234216', 'https://openalex.org/W2469477907', 'https://openalex.org/W2385696846', 'https://openalex.org/W2187779662', 'https://openalex.org/W2118195221', 'https://openalex.org/W2071095008', 'https://openalex.org/W2067825902', 'https://openalex.org/W2063989721', 'https://openalex.org/W2010676078', 'https://openalex.org/W1990766453', 'https://openalex.org/W1971545552', 'https://openalex.org/W1849296542', 'https://openalex.org/W1825832082', 'https://openalex.org/W1485383', 'https://openalex.org/W144631857', 'https://openalex.org/W111665831', 'https://openalex.org/W107474509'], 'abstract_inverted_index': {'Topoisomerase': [0, 55], 'II': [1, 33, 56, 103, 109], 'constitutes': [2], 'a': [3, 24, 63, 98], 'family': [4], 'of': [5, 17, 65, 101, 119, 130, 138, 143, 157, 178], 'nuclear': [6], 'enzymes': [7, 14], 'essential': [8], 'to': [9, 113, 152], 'all': [10], 'living': [11], 'cells.': [12], 'These': [13, 89], 'are': [15, 45, 160], 'capable': [16], 'transferring': [18], 'one': [19], 'DNA': [20, 29, 39, 48, 105, 122, 134], 'double': [21, 30], 'helix': [22], 'through': [23], 'transient': [25, 99], 'break': [26], 'in': [27, 38, 42, 47, 71, 106, 181], 'another': [28], 'helix.': [31], 'Type': [32], 'topoisomerases': [34], 'play': [35], 'important': [36], 'roles': [37], 'metabolic': [40, 135], 'processes,': [41], 'which': [43, 96, 107], 'they': [44], 'involved': [46], 'replication,': [49], 'transcription,': [50], 'chromosome': [51], 'condensation': [52], 'and': [53, 79, 84, 86, 154, 166], 'de-condensation.': [54], 'is': [57, 97, 110, 150], 'also': [58], 'the': [59, 76, 81, 87, 92, 117, 128, 140, 176], 'cellular': [60], 'target': [61], 'for': [62], 'number': [64], 'widely': [66], 'used': [67], 'anticancer': [68], 'agents': [69, 90, 149], 'currently': [70], 'clinical': [72, 141], 'use,': [73], 'such': [74, 131], 'as': [75, 147], 'anthracyclines': [77], '(daunorubicin': [78], 'doxorubicin),': [80], 'epipodophyllotoxins': [82], '(etoposide': [83], 'teniposide),': [85], 'aminoacridines.': [88], 'stimulate': [91], 'topoisomerase': [93, 102, 108, 145, 179], 'II-cleavable': [94], 'complex,': [95], 'configuration': [100], 'on': [104], 'covalently': [111], 'attached': [112], 'DNA.': [114], 'This': [115, 173], 'causes': [116], 'accumulation': [118], 'cytotoxic': [120], 'nonreversible': [121], 'double-': [123], 'strand': [124], 'breaks': [125], 'generated': [126], 'by': [127, 133], 'processing': [129], 'complexes': [132], 'processes.': [136], 'As': [137], 'present,': [139], 'use': [142], 'catalytic': [144], 'inhibitors': [146, 180], 'antineoplastic': [148], 'limited': [151, 168], 'aclarubicin': [153], 'MST-16.': [155], 'Both': [156], 'these': [158], 'compounds': [159], 'preferentially': [161], 'active': [162], 'toward': [163, 170], 'hematological': [164], 'malignancies': [165], 'show': [167], 'activity': [169], 'solid': [171], 'tumors.': [172], 'review': [174], 'explains': [175], 'role': [177], 'cancer': [182], 'therapy.': [183]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2186552112', 'counts_by_year': [], 'updated_date': '2024-12-09T22:34:59.074428', 'created_date': '2016-06-24'}