Synergistic Interaction between Histone Deacetylase and Topoisomerase II Inhibitors Is Mediated through Topoisomerase IIβ

Name: Work Video:
Duration: 3 min 30 s
Douglas C. Marchion; Elona Biçaku; Joel G. Turner; Adil Daud; Daniel M. Sullivan; Pamela N. Münster
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[103], 'selectively': [104], 'depleted': [105], 'using': [106], 'small': [107], 'interfering': [108], 'RNA': [109], 'antisense.': [111], 'Drug-induced': [112], 'formation': [113], 'cleavable': [115, 188], 'complexes': [116], 'involving': [117], 'by': [125], 'trapped-in-agarose': [126], 'immunostaining': [128], 'band': [130], 'depletion': [131], 'assays': [132], 'presence': [135], 'absence': [137], 'HDACi.': [139], 'Results:': [140], 'Preexposure': [141], 'increased': [144], 'cytotoxicity': [146, 182], 'poisons.': [150, 205], 'This': [151], 'down-regulation': [156], 'but': [161], 'had': [162], 'no': [163], 'IIβ.': [167], 'In': [168], 'setting': [170], 'HDACi-induced': [172, 192], 'chromatin': [173], 'decondensation': [174], 'depletion,': [178], 'poison': [181], 'mediated': [184], 'through': [185], 'complex': [189], 'formation.': [190], 'sensitization': [193], 'also': [195], 'observed': [196], 'target-specific': [200], 'Conclusions:': [206], 'recruitment': [208], 'target': [214], 'may': [215, 228], 'overcome': [216], 'primary': [217], 'emergent': [219], 'hence': [227], 'broaden': [229], 'applicability': [231], 'this': [233], 'important': [234], 'anticancer': [237]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2118195221', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-09T04:48:02.130414', 'created_date': '2016-06-24'}
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