Publication Information

{'id': 'https://openalex.org/W2167306613', 'doi': 'https://doi.org/10.1073/pnas.0511034103', 'title': 'A transgenic approach for RNA interference-based genetic screening in mice', 'display_name': 'A transgenic approach for RNA interference-based genetic screening in mice', 'publication_year': 2006, 'publication_date': '2006-02-06', 'ids': {'openalex': 'https://openalex.org/W2167306613', 'doi': 'https://doi.org/10.1073/pnas.0511034103', 'mag': '2167306613', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16461920', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/1413752'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.0511034103', 'pdf_url': 'https://www.pnas.org/doi/pdf/10.1073/pnas.0511034103', 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.pnas.org/doi/pdf/10.1073/pnas.0511034103', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5110884902', 'display_name': 'Shaohua Peng', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Shaohua Peng', 'raw_affiliation_strings': ['Departments of *Molecular Physiology and Biophysics and'], 'affiliations': [{'raw_affiliation_string': 'Departments of *Molecular Physiology and Biophysics and', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062313904', 'display_name': 'J. Philippe York', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'J. Philippe York', 'raw_affiliation_strings': ['Departments of *Molecular Physiology and Biophysics and'], 'affiliations': [{'raw_affiliation_string': 'Departments of *Molecular Physiology and Biophysics and', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5049362062', 'display_name': 'Pumin Zhang', 'orcid': 'https://orcid.org/0000-0003-4063-3008'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Pumin Zhang', 'raw_affiliation_strings': ['Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030', 'Departments of *Molecular Physiology and Biophysics and'], 'affiliations': [{'raw_affiliation_string': 'Departments of *Molecular Physiology and Biophysics and', 'institution_ids': []}, {'raw_affiliation_string': 'Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030', 'institution_ids': ['https://openalex.org/I181547552']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5049362062'], 'corresponding_institution_ids': ['https://openalex.org/I181547552'], 'apc_list': None, 'apc_paid': None, 'fwci': 2.819, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 57, 'citation_normalized_percentile': {'value': 0.839017, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '103', 'issue': '7', 'first_page': '2252', 'last_page': '2256'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10878', 'display_name': 'CRISPR and Genetic Engineering', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10878', 'display_name': 'CRISPR and Genetic Engineering', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12140', 'display_name': 'Renal and related cancers', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10725', 'display_name': 'RNA Interference and Gene Delivery', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/genetic-screen', 'display_name': 'Genetic screen', 'score': 0.5852879}], 'concepts': [{'id': 'https://openalex.org/C166703698', 'wikidata': 'https://www.wikidata.org/wiki/Q201993', 'display_name': 'RNA interference', 'level': 4, 'score': 0.95921004}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.9357978}, {'id': 'https://openalex.org/C102230213', 'wikidata': 'https://www.wikidata.org/wiki/Q430117', 'display_name': 'Transgene', 'level': 3, 'score': 0.74708563}, {'id': 'https://openalex.org/C190232843', 'wikidata': 'https://www.wikidata.org/wiki/Q1950808', 'display_name': 'Small hairpin RNA', 'level': 4, 'score': 0.71377075}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6731807}, {'id': 'https://openalex.org/C207177822', 'wikidata': 'https://www.wikidata.org/wiki/Q5050812', 'display_name': 'Genetic screen', 'level': 4, 'score': 0.5852879}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.5337058}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.4565179}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.44024387}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.41774693}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.38998002}, {'id': 'https://openalex.org/C127716648', 'wikidata': 'https://www.wikidata.org/wiki/Q104053', 'display_name': 'Phenotype', 'level': 3, 'score': 0.18775174}], 'mesh': [{'descriptor_ui': 'D005820', 'descriptor_name': 'Genetic Testing', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005822', 'descriptor_name': 'Genetic Vectors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051796', 'descriptor_name': 'Inhibitor of Differentiation Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D007679', 'descriptor_name': 'Kidney Medulla', 'qualifier_ui': 'Q000002', 'qualifier_name': 'abnormalities', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009024', 'descriptor_name': 'Morphogenesis', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D034622', 'descriptor_name': 'RNA Interference', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.0511034103', 'pdf_url': 'https://www.pnas.org/doi/pdf/10.1073/pnas.0511034103', 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1413752', 'pdf_url': 'https://europepmc.org/articles/pmc1413752?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1413752', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16461920', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.0511034103', 'pdf_url': 'https://www.pnas.org/doi/pdf/10.1073/pnas.0511034103', 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.69, 'id': 'https://metadata.un.org/sdg/15', 'display_name': 'Life on land'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 38, 'referenced_works': ['https://openalex.org/W1488480791', 'https://openalex.org/W1586462640', 'https://openalex.org/W1611419331', 'https://openalex.org/W1647075334', 'https://openalex.org/W1979765208', 'https://openalex.org/W2006117889', 'https://openalex.org/W2019387053', 'https://openalex.org/W2036853011', 'https://openalex.org/W2038783205', 'https://openalex.org/W2045406127', 'https://openalex.org/W2048607934', 'https://openalex.org/W2048690485', 'https://openalex.org/W2052312685', 'https://openalex.org/W2055085859', 'https://openalex.org/W2058705034', 'https://openalex.org/W2059829192', 'https://openalex.org/W2061623553', 'https://openalex.org/W2064690626', 'https://openalex.org/W2078317229', 'https://openalex.org/W2084828626', 'https://openalex.org/W2087099947', 'https://openalex.org/W2094697218', 'https://openalex.org/W2096018896', 'https://openalex.org/W2101722758', 'https://openalex.org/W2114406978', 'https://openalex.org/W2125164793', 'https://openalex.org/W2126669746', 'https://openalex.org/W2127639335', 'https://openalex.org/W2128491398', 'https://openalex.org/W2135151730', 'https://openalex.org/W2139103260', 'https://openalex.org/W2144654038', 'https://openalex.org/W2150809319', 'https://openalex.org/W2159511823', 'https://openalex.org/W2318718797', 'https://openalex.org/W4211039187', 'https://openalex.org/W4285719527', 'https://openalex.org/W4323238746'], 'related_works': ['https://openalex.org/W4391126805', 'https://openalex.org/W4390297994', 'https://openalex.org/W2413319726', 'https://openalex.org/W2289304380', 'https://openalex.org/W2167306613', 'https://openalex.org/W2139684752', 'https://openalex.org/W2093213574', 'https://openalex.org/W2076785949', 'https://openalex.org/W2021611122', 'https://openalex.org/W1963563485'], 'abstract_inverted_index': {'Genetic': [0], 'screening': [1, 48, 91, 122], 'is': [2], 'the': [3, 67, 96, 106, 109, 115], 'most': [4], 'powerful': [5], 'method': [6], 'through': [7, 60], 'which': [8], 'to': [9], 'uncover': [10], 'gene': [11, 55], 'function.': [12], 'It': [13], 'has': [14], 'been': [15], 'applied': [16], 'very': [17], 'successfully': [18], 'in': [19, 25, 46, 49, 84, 95, 105, 123], 'lower': [20], 'organisms': [21], 'but': [22], 'seldom': [23], 'attempted': [24], 'mammalian': [26], 'species': [27], 'because': [28], 'of': [29, 103, 108, 117], 'their': [30], 'long': [31], 'generation': [32], 'time.': [33], 'In': [34, 88], 'this': [35], 'study,': [36], 'we': [37, 98], 'exploit': [38], 'RNA': [39], 'interference': [40], '(RNAi)': [41], 'for': [42, 81, 92, 120], 'its': [43], 'potential': [44, 101], 'use': [45], 'genetic': [47, 121], 'mice.': [50, 124], 'We': [51], 'show': [52], 'that': [53], 'RNAi-induced': [54], 'knockdown': [56, 76], 'can': [57, 78], 'be': [58, 79], 'generated': [59], 'introducing': [61], 'small': [62], 'hairpin': [63], 'RNA-expressing': [64], 'constructs': [65], 'into': [66], 'mouse': [68], 'as': [69], 'transgenes': [70], 'via': [71], 'conventional': [72], 'pronuclear': [73], 'injection.': [74], 'The': [75], 'effect': [77], 'transmitted': [80], 'many': [82], 'generations': [83], 'these': [85], 'transgenic': [86], 'animals.': [87], 'a': [89, 100], 'small-scale': [90], 'developmental': [93], 'defects': [94], 'kidney,': [97], 'uncovered': [99], 'role': [102], 'Id4': [104], 'formation': [107], 'renal': [110], 'medulla.': [111], 'Our': [112], 'results': [113], 'demonstrate': [114], 'feasibility': [116], 'using': [118], 'RNAi': [119]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2167306613', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-17T09:50:57.239545', 'created_date': '2016-06-24'}