Publication Information

{'id': 'https://openalex.org/W2139684752', 'doi': 'https://doi.org/10.1152/physiol.00002.2007', 'title': 'Transgenic RNA Interference in Mice', 'display_name': 'Transgenic RNA Interference in Mice', 'publication_year': 2007, 'publication_date': '2007-06-01', 'ids': {'openalex': 'https://openalex.org/W2139684752', 'doi': 'https://doi.org/10.1152/physiol.00002.2007', 'mag': '2139684752', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17557936'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/physiol.00002.2007', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S88977973', 'display_name': 'Physiology', 'issn_l': '1548-9221', 'issn': ['1548-9221', '1548-9213'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320155', 'host_organization_name': 'American Physiological Society', 'host_organization_lineage': ['https://openalex.org/P4310320155'], 'host_organization_lineage_names': ['American Physiological Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101456403', 'display_name': 'Xue Gao', 'orcid': 'https://orcid.org/0000-0002-9083-6658'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Xue Gao', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology, and'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology, and', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5049362062', 'display_name': 'Pumin Zhang', 'orcid': 'https://orcid.org/0000-0003-4063-3008'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Pumin Zhang', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology, and', 'Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology, and', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas', 'institution_ids': ['https://openalex.org/I181547552']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.568, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 37, 'citation_normalized_percentile': {'value': 0.299431, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '22', 'issue': '3', 'first_page': '161', 'last_page': '166'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10725', 'display_name': 'RNA Interference and Gene Delivery', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10725', 'display_name': 'RNA Interference and Gene Delivery', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10613', 'display_name': 'Virus-based gene therapy research', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10207', 'display_name': 'Advanced biosensing and bioanalysis techniques', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/rna-silencing', 'display_name': 'RNA Silencing', 'score': 0.489932}], 'concepts': [{'id': 'https://openalex.org/C166703698', 'wikidata': 'https://www.wikidata.org/wiki/Q201993', 'display_name': 'RNA interference', 'level': 4, 'score': 0.95193243}, {'id': 'https://openalex.org/C190232843', 'wikidata': 'https://www.wikidata.org/wiki/Q1950808', 'display_name': 'Small hairpin RNA', 'level': 4, 'score': 0.94736874}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.8122934}, {'id': 'https://openalex.org/C102230213', 'wikidata': 'https://www.wikidata.org/wiki/Q430117', 'display_name': 'Transgene', 'level': 3, 'score': 0.72630864}, {'id': 'https://openalex.org/C22615655', 'wikidata': 'https://www.wikidata.org/wiki/Q203221', 'display_name': 'Small interfering RNA', 'level': 4, 'score': 0.6620232}, {'id': 'https://openalex.org/C119056186', 'wikidata': 'https://www.wikidata.org/wiki/Q1431332', 'display_name': 'Gene silencing', 'level': 3, 'score': 0.6342108}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.57353866}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.49972796}, {'id': 'https://openalex.org/C2191507', 'wikidata': 'https://www.wikidata.org/wiki/Q7277185', 'display_name': 'RNA silencing', 'level': 5, 'score': 0.489932}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.45834136}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.45680872}, {'id': 'https://openalex.org/C141035611', 'wikidata': 'https://www.wikidata.org/wiki/Q5532934', 'display_name': 'Genetically modified mouse', 'level': 4, 'score': 0.43718866}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.4031751}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.17291963}], 'mesh': [{'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D008967', 'descriptor_name': 'Molecular Biology', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D034622', 'descriptor_name': 'RNA Interference', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008967', 'descriptor_name': 'Molecular Biology', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1152/physiol.00002.2007', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S88977973', 'display_name': 'Physiology', 'issn_l': '1548-9221', 'issn': ['1548-9221', '1548-9213'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320155', 'host_organization_name': 'American Physiological Society', 'host_organization_lineage': ['https://openalex.org/P4310320155'], 'host_organization_lineage_names': ['American Physiological Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17557936', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.44, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 51, 'referenced_works': ['https://openalex.org/W144423133', 'https://openalex.org/W1488480791', 'https://openalex.org/W1523024660', 'https://openalex.org/W1586462640', 'https://openalex.org/W1611419331', 'https://openalex.org/W1647075334', 'https://openalex.org/W1931443173', 'https://openalex.org/W1974861468', 'https://openalex.org/W1980017221', 'https://openalex.org/W1988967884', 'https://openalex.org/W1992941735', 'https://openalex.org/W1999596958', 'https://openalex.org/W2002615250', 'https://openalex.org/W2006117889', 'https://openalex.org/W2016272344', 'https://openalex.org/W2019387053', 'https://openalex.org/W2020923434', 'https://openalex.org/W2022501852', 'https://openalex.org/W2022939912', 'https://openalex.org/W2032216015', 'https://openalex.org/W2036853011', 'https://openalex.org/W2037402545', 'https://openalex.org/W2038783205', 'https://openalex.org/W2048607934', 'https://openalex.org/W2048690485', 'https://openalex.org/W2052312685', 'https://openalex.org/W2057627686', 'https://openalex.org/W2084828626', 'https://openalex.org/W2086177466', 'https://openalex.org/W2096018896', 'https://openalex.org/W2101713927', 'https://openalex.org/W2101722758', 'https://openalex.org/W2109623486', 'https://openalex.org/W2110029412', 'https://openalex.org/W2114406978', 'https://openalex.org/W2126669746', 'https://openalex.org/W2128491398', 'https://openalex.org/W2133898735', 'https://openalex.org/W2135151730', 'https://openalex.org/W2144654038', 'https://openalex.org/W2150809319', 'https://openalex.org/W2151922790', 'https://openalex.org/W2153747430', 'https://openalex.org/W2155797717', 'https://openalex.org/W2156067308', 'https://openalex.org/W2160129372', 'https://openalex.org/W2167306613', 'https://openalex.org/W2167557255', 'https://openalex.org/W4211039187', 'https://openalex.org/W4248378708', 'https://openalex.org/W4285719527'], 'related_works': ['https://openalex.org/W4295095065', 'https://openalex.org/W3144044208', 'https://openalex.org/W3140077495', 'https://openalex.org/W2981114495', 'https://openalex.org/W2884140292', 'https://openalex.org/W2289304380', 'https://openalex.org/W2139684752', 'https://openalex.org/W2119212619', 'https://openalex.org/W2073840770', 'https://openalex.org/W153428622'], 'abstract_inverted_index': {'The': [0, 19], 'discovery': [1, 25], 'that': [2, 70], 'small': [3], 'interfering': [4], 'RNA': [5, 71], 'duplexes': [6], '(siRNA)': [7], 'can': [8, 74], 'silence': [9], 'gene': [10, 30], 'expression': [11], 'in': [12, 32, 78, 99, 116], 'mammalian': [13], 'cells': [14, 101], 'has': [15, 26], 'revolutionized': [16], 'biomedical': [17], 'research.': [18], 'most': [20], 'successful': [21], 'application': [22], 'of': [23, 42, 67, 94, 119], 'the': [24, 39, 92, 114, 117], 'been': [27], 'to': [28], 'study': [29, 93], 'function': [31], 'cultured': [33, 100], 'human': [34], 'or': [35], 'mouse': [36], 'cells.': [37], 'However,': [38], 'knockdown': [40], 'effect': [41], 'siRNA': [43], 'is': [44, 62, 69], 'only': [45, 90], 'transient.': [46], 'To': [47], 'achieve': [48], 'a': [49, 60], 'more': [50], 'sustained': [51], 'gene-silencing': [52], 'effect,': [53], 'shRNA': [54, 68], '(small': [55], 'hairpin': [56], 'RNA)': [57], 'expressed': [58], 'from': [59], 'vector': [61], 'preferred.': [63], 'An': [64], 'additional': [65], 'benefit': [66], 'interference': [72], '(RNAi)': [73], 'now': [75], 'be': [76], 'applied': [77], 'vivo': [79], 'through': [80], 'delivering': [81], 'shRNA-expressing': [82], 'vectors': [83], 'by': [84], 'transgenic': [85, 120], 'technology.': [86], 'Transgenic': [87], 'RNAi': [88, 121], 'not': [89, 97], 'allows': [91], 'biological': [95], 'processes': [96], 'present': [98], 'but': [102], 'also': [103], 'offers': [104], 'chronic': [105], 'therapeutic': [106], 'potentials.': [107], 'In': [108], 'this': [109], 'review,': [110], 'we': [111], 'will': [112], 'summarize': [113], 'developments': [115], 'generation': [118], 'mice.': [122]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2139684752', 'counts_by_year': [{'year': 2018, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-17T16:14:50.878108', 'created_date': '2016-06-24'}