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Title: $Silica Exposure and Risk of Lung Cancer: Pathophysiological Hypotheses in Research Amenable to Testing by Epidemiological Methods
Abstract: Abstract Abstract The selection of a design for an epidemiological study and the particular design features it incorporates are dependent on basic assumptions about pathophysiology. The study of silica-related disease and its relationship to carcinogenesis is no exception. In particular, the possible association between silica-induced fibrogenesis and silica-associated carcinogenesis is a key issue. Aspects of the pathophysiology of silicosis and other silica-related diseases were reviewed for hypotheses regarding the mechanisms of carcinogenicity. The appropriate epidemiologic approaches to testing these hypotheses are considered. Data from a major study of hard-rock miners in Guangxi province, People's Republic of China, developed in collaboration with Drs. Fu Hua, Gu Xueqi, Jin Xipeng, Yu Shunzhang, and Wu Kaiguo, are used to illustrate and test some hypotheses. The data are most consistent with a direct effect of silica exposure, with or without associated silicosis. Guidotti, T.L.: Silica Exposure and Risk of Lung Cancer: Pathophysiological Hypotheses in Research Amenable to Testing by Epidemiological Methods. Appl. Occup. Environ. Hyg. 10(12):1075–1080; 1995.