Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2157155969', 'doi': 'https://doi.org/10.1186/2051-5960-1-6', 'title': 'Direct detection of alpha synuclein oligomers in vivo', 'display_name': 'Direct detection of alpha synuclein oligomers in vivo', 'publication_year': 2013, 'publication_date': '2013-05-09', 'ids': {'openalex': 'https://openalex.org/W2157155969', 'doi': 'https://doi.org/10.1186/2051-5960-1-6', 'mag': '2157155969', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/24252244', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3776213'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/2051-5960-1-6', 'pdf_url': 'https://actaneurocomms.biomedcentral.com/track/pdf/10.1186/2051-5960-1-6', 'source': {'id': 'https://openalex.org/S2764650462', 'display_name': 'Acta Neuropathologica Communications', 'issn_l': '2051-5960', 'issn': ['2051-5960'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://actaneurocomms.biomedcentral.com/track/pdf/10.1186/2051-5960-1-6', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5081013988', 'display_name': 'Hemi Dimant', 'orcid': 'https://orcid.org/0000-0002-4554-7873'}, 'institutions': [{'id': 'https://openalex.org/I4210112815', 'display_name': 'MaineGeneral Medical Center', 'ror': 'https://ror.org/022nbxr62', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210112815']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hemi Dimant', 'raw_affiliation_strings': ['MassGeneral Institute for Neurodegenerative Disease, Department Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA'], 'affiliations': [{'raw_affiliation_string': 'MassGeneral Institute for Neurodegenerative Disease, Department Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA', 'institution_ids': ['https://openalex.org/I4210112815', 'https://openalex.org/I136199984', 'https://openalex.org/I4210087915']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033165479', 'display_name': 'Suneil K. Kalia', 'orcid': 'https://orcid.org/0000-0003-2054-1915'}, 'institutions': [{'id': 'https://openalex.org/I4210112815', 'display_name': 'MaineGeneral Medical Center', 'ror': 'https://ror.org/022nbxr62', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210112815']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Suneil K Kalia', 'raw_affiliation_strings': ['MassGeneral Institute for Neurodegenerative Disease, Department Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA'], 'affiliations': [{'raw_affiliation_string': 'MassGeneral Institute for Neurodegenerative Disease, Department Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA', 'institution_ids': ['https://openalex.org/I4210112815', 'https://openalex.org/I136199984', 'https://openalex.org/I4210087915']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077133037', 'display_name': 'Lorraine V. Kalia', 'orcid': 'https://orcid.org/0000-0002-9384-1305'}, 'institutions': [{'id': 'https://openalex.org/I4210112815', 'display_name': 'MaineGeneral Medical Center', 'ror': 'https://ror.org/022nbxr62', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210112815']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lorraine V Kalia', 'raw_affiliation_strings': ['MassGeneral Institute for Neurodegenerative Disease, Department Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA'], 'affiliations': [{'raw_affiliation_string': 'MassGeneral Institute for Neurodegenerative Disease, Department Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA', 'institution_ids': ['https://openalex.org/I4210112815', 'https://openalex.org/I136199984', 'https://openalex.org/I4210087915']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101676456', 'display_name': 'Liya Zhu', 'orcid': 'https://orcid.org/0009-0004-2257-8679'}, 'institutions': [{'id': 'https://openalex.org/I4210112815', 'display_name': 'MaineGeneral Medical Center', 'ror': 'https://ror.org/022nbxr62', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210112815']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Liya N Zhu', 'raw_affiliation_strings': ['MassGeneral Institute for Neurodegenerative Disease, Department Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA'], 'affiliations': [{'raw_affiliation_string': 'MassGeneral Institute for Neurodegenerative Disease, Department Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA', 'institution_ids': ['https://openalex.org/I4210112815', 'https://openalex.org/I136199984', 'https://openalex.org/I4210087915']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066994960', 'display_name': 'Laura N. Kibuuka', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210112815', 'display_name': 'MaineGeneral Medical Center', 'ror': 'https://ror.org/022nbxr62', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210112815']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Laura Kibuuka', 'raw_affiliation_strings': ['MassGeneral Institute for Neurodegenerative Disease, Department Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA'], 'affiliations': [{'raw_affiliation_string': 'MassGeneral Institute for Neurodegenerative Disease, Department Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA', 'institution_ids': ['https://openalex.org/I4210112815', 'https://openalex.org/I136199984', 'https://openalex.org/I4210087915']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041028445', 'display_name': 'Darius Ebrahimi‐Fakhari', 'orcid': 'https://orcid.org/0000-0002-0026-4714'}, 'institutions': [{'id': 'https://openalex.org/I4210112815', 'display_name': 'MaineGeneral Medical Center', 'ror': 'https://ror.org/022nbxr62', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210112815']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Darius Ebrahimi-Fakhari', 'raw_affiliation_strings': ['MassGeneral Institute for Neurodegenerative Disease, Department Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA'], 'affiliations': [{'raw_affiliation_string': 'MassGeneral Institute for Neurodegenerative Disease, Department Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA', 'institution_ids': ['https://openalex.org/I4210112815', 'https://openalex.org/I136199984', 'https://openalex.org/I4210087915']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045713119', 'display_name': 'Nikolaus R. McFarland', 'orcid': 'https://orcid.org/0000-0002-8699-8857'}, 'institutions': [{'id': 'https://openalex.org/I4210112815', 'display_name': 'MaineGeneral Medical Center', 'ror': 'https://ror.org/022nbxr62', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210112815']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nikolaus R McFarland', 'raw_affiliation_strings': ['MassGeneral Institute for Neurodegenerative Disease, Department Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA'], 'affiliations': [{'raw_affiliation_string': 'MassGeneral Institute for Neurodegenerative Disease, Department Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA', 'institution_ids': ['https://openalex.org/I4210112815', 'https://openalex.org/I136199984', 'https://openalex.org/I4210087915']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080731257', 'display_name': 'Zhanyun Fan', 'orcid': 'https://orcid.org/0009-0008-2214-188X'}, 'institutions': [{'id': 'https://openalex.org/I4210112815', 'display_name': 'MaineGeneral Medical Center', 'ror': 'https://ror.org/022nbxr62', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210112815']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Zhanyun Fan', 'raw_affiliation_strings': ['MassGeneral Institute for Neurodegenerative Disease, Department Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA'], 'affiliations': [{'raw_affiliation_string': 'MassGeneral Institute for Neurodegenerative Disease, Department Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA', 'institution_ids': ['https://openalex.org/I4210112815', 'https://openalex.org/I136199984', 'https://openalex.org/I4210087915']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068688487', 'display_name': 'Bradley T. Hyman', 'orcid': 'https://orcid.org/0000-0002-7959-9401'}, 'institutions': [{'id': 'https://openalex.org/I4210112815', 'display_name': 'MaineGeneral Medical Center', 'ror': 'https://ror.org/022nbxr62', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210112815']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Bradley T Hyman', 'raw_affiliation_strings': ['MassGeneral Institute for Neurodegenerative Disease, Department Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA'], 'affiliations': [{'raw_affiliation_string': 'MassGeneral Institute for Neurodegenerative Disease, Department Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA', 'institution_ids': ['https://openalex.org/I4210112815', 'https://openalex.org/I136199984', 'https://openalex.org/I4210087915']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5000693728', 'display_name': 'Pamela J. McLean', 'orcid': 'https://orcid.org/0000-0003-4870-5715'}, 'institutions': [{'id': 'https://openalex.org/I4210112815', 'display_name': 'MaineGeneral Medical Center', 'ror': 'https://ror.org/022nbxr62', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210112815']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Pamela J McLean', 'raw_affiliation_strings': ['MassGeneral Institute for Neurodegenerative Disease, Department Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA'], 'affiliations': [{'raw_affiliation_string': 'MassGeneral Institute for Neurodegenerative Disease, Department Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA', 'institution_ids': ['https://openalex.org/I4210112815', 'https://openalex.org/I136199984', 'https://openalex.org/I4210087915']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2390, 'currency': 'GBP', 'value_usd': 2931, 'provenance': 'doaj'}, 'apc_paid': {'value': 2390, 'currency': 'GBP', 'value_usd': 2931, 'provenance': 'doaj'}, 'fwci': 4.849, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 72, 'citation_normalized_percentile': {'value': 0.999908, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '1', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10085', 'display_name': "Pathophysiology of Parkinson's Disease", 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10085', 'display_name': "Pathophysiology of Parkinson's Disease", 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10483', 'display_name': 'Roles of Neurotrophins in Nervous System Function', 'score': 0.9966, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10949', 'display_name': 'Molecular Mechanisms of Neurodegenerative Diseases', 'score': 0.9945, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pars-compacta', 'display_name': 'Pars compacta', 'score': 0.8661749}, {'id': 'https://openalex.org/keywords/neuromelanin', 'display_name': 'Neuromelanin', 'score': 0.5614574}, {'id': 'https://openalex.org/keywords/a-synuclein', 'display_name': 'a-Synuclein', 'score': 0.48}], 'concepts': [{'id': 'https://openalex.org/C2780938664', 'wikidata': 'https://www.wikidata.org/wiki/Q753278', 'display_name': 'Substantia nigra', 'level': 4, 'score': 0.9767945}, {'id': 'https://openalex.org/C2776773494', 'wikidata': 'https://www.wikidata.org/wiki/Q3366041', 'display_name': 'Pars compacta', 'level': 5, 'score': 0.8661749}, {'id': 'https://openalex.org/C2781449126', 'wikidata': 'https://www.wikidata.org/wiki/Q288591', 'display_name': 'Alpha-synuclein', 'level': 4, 'score': 0.8214069}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.6001272}, {'id': 'https://openalex.org/C43310041', 'wikidata': 'https://www.wikidata.org/wiki/Q1981297', 'display_name': 'Neuromelanin', 'level': 5, 'score': 0.5614574}, {'id': 'https://openalex.org/C2779734285', 'wikidata': 'https://www.wikidata.org/wiki/Q11085', 'display_name': "Parkinson's disease", 'level': 3, 'score': 0.54910445}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.51528287}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5037603}, {'id': 'https://openalex.org/C137183658', 'wikidata': 'https://www.wikidata.org/wiki/Q461076', 'display_name': 'Dopaminergic', 'level': 3, 'score': 0.4777288}, {'id': 'https://openalex.org/C513476851', 'wikidata': 'https://www.wikidata.org/wiki/Q170304', 'display_name': 'Dopamine', 'level': 2, 'score': 0.44619754}, {'id': 'https://openalex.org/C2780062018', 'wikidata': 'https://www.wikidata.org/wiki/Q1319792', 'display_name': 'Striatum', 'level': 3, 'score': 0.4257167}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.33644965}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.31242922}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.25129658}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.06313962}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.05766332}], 'mesh': [{'descriptor_ui': 'D003342', 'descriptor_name': 'Corpus Striatum', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D020734', 'descriptor_name': 'Parkinsonian Disorders', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013378', 'descriptor_name': 'Substantia Nigra', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D051844', 'descriptor_name': 'alpha-Synuclein', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001426', 'descriptor_name': 'Bacterial Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003342', 'descriptor_name': 'Corpus Striatum', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D003342', 'descriptor_name': 'Corpus Striatum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000229', 'descriptor_name': 'Dependovirus', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000229', 'descriptor_name': 'Dependovirus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059290', 'descriptor_name': 'Dopaminergic Neurons', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D059290', 'descriptor_name': 'Dopaminergic Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059290', 'descriptor_name': 'Dopaminergic Neurons', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D005822', 'descriptor_name': 'Genetic Vectors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005911', 'descriptor_name': 'Gliosis', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005911', 'descriptor_name': 'Gliosis', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D005911', 'descriptor_name': 'Gliosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008164', 'descriptor_name': 'Luminescent Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008164', 'descriptor_name': 'Luminescent Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008164', 'descriptor_name': 'Luminescent Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009434', 'descriptor_name': 'Neural Pathways', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D009434', 'descriptor_name': 'Neural Pathways', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009434', 'descriptor_name': 'Neural Pathways', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015213', 'descriptor_name': 'Neuroimmunomodulation', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D015213', 'descriptor_name': 'Neuroimmunomodulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020734', 'descriptor_name': 'Parkinsonian Disorders', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D020734', 'descriptor_name': 'Parkinsonian Disorders', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013378', 'descriptor_name': 'Substantia Nigra', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D013378', 'descriptor_name': 'Substantia Nigra', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051844', 'descriptor_name': 'alpha-Synuclein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051844', 'descriptor_name': 'alpha-Synuclein', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051844', 'descriptor_name': 'alpha-Synuclein', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 6, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/2051-5960-1-6', 'pdf_url': 'https://actaneurocomms.biomedcentral.com/track/pdf/10.1186/2051-5960-1-6', 'source': {'id': 'https://openalex.org/S2764650462', 'display_name': 'Acta Neuropathologica Communications', 'issn_l': '2051-5960', 'issn': ['2051-5960'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3776213', 'pdf_url': 'https://europepmc.org/articles/pmc3776213?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://nrs.harvard.edu/urn-3:HUL.InstRepos:11879148', 'pdf_url': 'https://dash.harvard.edu/bitstream/1/11879148/1/3776213.pdf', 'source': {'id': 'https://openalex.org/S4306401540', 'display_name': 'Digital Access to Scholarship at Harvard (DASH) (Harvard University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I136199984', 'host_organization_name': 'Harvard University', 'host_organization_lineage': ['https://openalex.org/I136199984'], 'host_organization_lineage_names': ['Harvard University'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/1807/86937', 'pdf_url': 'https://tspace.library.utoronto.ca/bitstream/1807/86937/1/40478_2013_Article_13.pdf', 'source': {'id': 'https://openalex.org/S4306400261', 'display_name': 'TSpace (University of Toronto)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I185261750', 'host_organization_name': 'University of Toronto', 'host_organization_lineage': ['https://openalex.org/I185261750'], 'host_organization_lineage_names': ['University of Toronto'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776213', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24252244', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/2051-5960-1-6', 'pdf_url': 'https://actaneurocomms.biomedcentral.com/track/pdf/10.1186/2051-5960-1-6', 'source': {'id': 'https://openalex.org/S2764650462', 'display_name': 'Acta Neuropathologica Communications', 'issn_l': '2051-5960', 'issn': ['2051-5960'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 39, 'referenced_works': ['https://openalex.org/W1252751620', 'https://openalex.org/W1482464462', 'https://openalex.org/W1588992473', 'https://openalex.org/W1971274336', 'https://openalex.org/W1971599063', 'https://openalex.org/W1984156308', 'https://openalex.org/W1989734945', 'https://openalex.org/W1995191747', 'https://openalex.org/W1997524825', 'https://openalex.org/W2006157687', 'https://openalex.org/W2009556855', 'https://openalex.org/W2014413787', 'https://openalex.org/W2024041381', 'https://openalex.org/W2028955297', 'https://openalex.org/W2029000167', 'https://openalex.org/W2034210468', 'https://openalex.org/W2034887565', 'https://openalex.org/W2044849627', 'https://openalex.org/W2050786534', 'https://openalex.org/W2052885679', 'https://openalex.org/W2052930127', 'https://openalex.org/W2056675110', 'https://openalex.org/W2057358353', 'https://openalex.org/W2061466239', 'https://openalex.org/W2073852487', 'https://openalex.org/W2084307273', 'https://openalex.org/W2086357928', 'https://openalex.org/W2086483799', 'https://openalex.org/W2091265794', 'https://openalex.org/W2111405228', 'https://openalex.org/W2114835861', 'https://openalex.org/W2142297263', 'https://openalex.org/W2143604504', 'https://openalex.org/W2145294211', 'https://openalex.org/W2150656456', 'https://openalex.org/W2154737306', 'https://openalex.org/W2157102136', 'https://openalex.org/W2162079087', 'https://openalex.org/W2178984859'], 'related_works': ['https://openalex.org/W4240942801', 'https://openalex.org/W3049065873', 'https://openalex.org/W2903786868', 'https://openalex.org/W2630340255', 'https://openalex.org/W2160509226', 'https://openalex.org/W2139856185', 'https://openalex.org/W2086361121', 'https://openalex.org/W2073396373', 'https://openalex.org/W1654412445', 'https://openalex.org/W1558984540'], 'abstract_inverted_index': {'Rat': [0], 'models': [1, 75], 'of': [2, 56, 65, 101, 162, 182], "Parkinson's": [3, 222], 'disease': [4, 13, 223], 'are': [5], 'widely': [6], 'used': [7], 'to': [8, 16, 30, 49, 86, 95, 125, 202, 228], 'elucidate': [9], 'the': [10, 41, 51, 60, 69, 96, 112, 122, 145, 152, 177, 180, 188, 199, 208, 221], 'mechanisms': [11], 'underlying': [12], 'etiology': [14], 'or': [15, 28, 44, 98], 'investigate': [17], 'therapeutic': [18, 238], 'approaches.': [19], 'Models': [20], 'were': [21], 'developed': [22, 211], 'using': [23, 46, 81], 'toxins': [24], 'such': [25], 'as': [26], 'MPTP': [27], '6-OHDA': [29], 'specifically': [31], 'target': [32], 'dopaminergic': [33, 173], 'neurons': [34], 'resulting': [35], 'in': [36, 40, 59, 73, 103, 136, 140, 151, 158, 163, 176, 187, 194, 198, 207, 234], 'acute': [37], 'neuronal': [38], 'loss': [39, 175], 'substantia': [42, 61, 105, 153, 178], 'nigra': [43, 106, 154], 'by': [45], 'viral': [47, 117], 'vectors': [48], 'induce': [50], 'specific': [52], 'and': [53, 76, 109, 128, 135, 155, 185, 236], 'gradual': [54], 'expression': [55], 'alpha': [57, 130], 'synuclein': [58, 67, 131, 232], 'nigra.': [62], 'The': [63], 'detection': [64], 'alpha-': [66, 231], 'oligomers,': [68], 'presumed': [70], 'toxic': [71], 'species,': [72], 'these': [74], 'others': [77], 'has': [78], 'been': [79], 'possible': [80], 'only': [82], 'indirect': [83], 'biochemical': [84], 'approaches': [85, 239], 'date.': [87], 'Here': [88], 'we': [89, 191], 'coinjected': [90], 'AAVs': [91], 'encoding': [92], 'alpha-synuclein': [93, 165, 171, 205, 241], 'fused': [94], 'N-': [97], 'C-terminal': [99], 'half': [100], 'VenusYFP': [102, 142], 'rat': [104], 'pars': [107], 'compacta': [108], 'describe': [110], 'for': [111, 220], 'first': [113], 'time': [114], 'a': [115, 212, 218], 'novel': [116], 'vector': [118], 'rodent': [119], 'model': [120, 215], 'with': [121, 226], 'unique': [123, 213], 'ability': [124], 'directly': [126, 203, 229], 'detect': [127, 230], 'track': [129], 'oligomers': [132, 166, 206, 233], 'ex': [133], 'vivo': [134, 164, 195, 235], 'vivo.Viral': [137], 'coinjection': [138], 'resulted': [139], 'widespread': [141], 'signal': [143], 'within': [144], 'nigrostriatal': [146], 'pathway,': [147], 'including': [148], 'cell': [149], 'bodies': [150], 'synaptic': [156], 'accumulation': [157], 'striatal': [159], 'terminals,': [160], 'suggestive': [161], 'formation.': [167], 'Transduced': [168], 'rats': [169], 'showed': [170], 'induced': [172], 'neuron': [174], 'nigra,': [179], 'appearance': [181], 'dystrophic': [183], 'neurites,': [184], 'gliosis': [186], 'striatum.': [189], 'Moreover,': [190], 'have': [192, 210], 'applied': [193], 'imaging': [196], 'techniques': [197], 'living': [200], 'mouse': [201], 'image': [204], 'cortex.We': [209], 'animal': [214], 'that': [216], 'provides': [217], 'tool': [219], 'research': [224], 'community': [225], 'which': [227], 'screen': [237], 'targeting': [240], 'oligomers.': [242]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2157155969', 'counts_by_year': [{'year': 2024, 'cited_by_count': 16}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-09-01T04:20:50.227683', 'created_date': '2016-06-24'}