Publication Information

{'id': 'https://openalex.org/W2154694480', 'doi': 'https://doi.org/10.1073/pnas.1005191107', 'title': 'miR-33 links SREBP-2 induction to repression of sterol transporters', 'display_name': 'miR-33 links SREBP-2 induction to repression of sterol transporters', 'publication_year': 2010, 'publication_date': '2010-06-21', 'ids': {'openalex': 'https://openalex.org/W2154694480', 'doi': 'https://doi.org/10.1073/pnas.1005191107', 'mag': '2154694480', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20566875', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2901433'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.1005191107', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://doi.org/10.1073/pnas.1005191107', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5056664325', 'display_name': 'Tyler J. Marquart', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I47838141', 'display_name': 'Saint Louis University', 'ror': 'https://ror.org/01p7jjy08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I47838141']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Tyler J. Marquart', 'raw_affiliation_strings': ['Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University, St. Louis, MO 63104;', 'Saint Louis University School of Medicine, St. Louis, MO,'], 'affiliations': [{'raw_affiliation_string': 'Saint Louis University School of Medicine, St. Louis, MO,', 'institution_ids': ['https://openalex.org/I47838141']}, {'raw_affiliation_string': 'Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University, St. Louis, MO 63104;', 'institution_ids': ['https://openalex.org/I47838141']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049287980', 'display_name': 'Ryan M. Allen', 'orcid': 'https://orcid.org/0000-0002-8057-3436'}, 'institutions': [{'id': 'https://openalex.org/I47838141', 'display_name': 'Saint Louis University', 'ror': 'https://ror.org/01p7jjy08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I47838141']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ryan M. Allen', 'raw_affiliation_strings': ['Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University, St. Louis, MO 63104;', 'Saint Louis University School of Medicine, St. Louis, MO,'], 'affiliations': [{'raw_affiliation_string': 'Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University, St. Louis, MO 63104;', 'institution_ids': ['https://openalex.org/I47838141']}, {'raw_affiliation_string': 'Saint Louis University School of Medicine, St. Louis, MO,', 'institution_ids': ['https://openalex.org/I47838141']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060731094', 'display_name': 'Daniel S. Ory', 'orcid': 'https://orcid.org/0000-0002-9640-4901'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Daniel S. Ory', 'raw_affiliation_strings': ['Diabetic Cardiovascular Disease Center, Washington University, St. Louis, MO 63110; and'], 'affiliations': [{'raw_affiliation_string': 'Diabetic Cardiovascular Disease Center, Washington University, St. Louis, MO 63110; and', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5011059025', 'display_name': 'Ángel Baldán', 'orcid': 'https://orcid.org/0000-0003-0373-8492'}, 'institutions': [{'id': 'https://openalex.org/I47838141', 'display_name': 'Saint Louis University', 'ror': 'https://ror.org/01p7jjy08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I47838141']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Ángel Baldán', 'raw_affiliation_strings': ['Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University, St. Louis, MO 63104;', 'Saint Louis University Center for Cardiovascular Research, St. Louis, MO 63104'], 'affiliations': [{'raw_affiliation_string': 'Saint Louis University Center for Cardiovascular Research, St. Louis, MO 63104', 'institution_ids': ['https://openalex.org/I47838141']}, {'raw_affiliation_string': 'Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University, St. Louis, MO 63104;', 'institution_ids': ['https://openalex.org/I47838141']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5011059025'], 'corresponding_institution_ids': ['https://openalex.org/I47838141'], 'apc_list': None, 'apc_paid': None, 'fwci': 43.532, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 525, 'citation_normalized_percentile': {'value': 0.999979, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '107', 'issue': '27', 'first_page': '12228', 'last_page': '12232'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11618', 'display_name': 'Cholesterol and Lipid Metabolism', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11618', 'display_name': 'Cholesterol and Lipid Metabolism', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10570', 'display_name': 'Drug Transport and Resistance Mechanisms', 'score': 0.9882, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11072', 'display_name': 'Peroxisome Proliferator-Activated Receptors', 'score': 0.9738, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/abcg1', 'display_name': 'ABCG1', 'score': 0.90418094}, {'id': 'https://openalex.org/keywords/liver-x-receptor', 'display_name': 'Liver X receptor', 'score': 0.85554206}, {'id': 'https://openalex.org/keywords/efflux', 'display_name': 'Efflux', 'score': 0.53804135}, {'id': 'https://openalex.org/keywords/reverse-cholesterol-transport', 'display_name': 'Reverse cholesterol transport', 'score': 0.5248354}, {'id': 'https://openalex.org/keywords/pcsk9', 'display_name': 'PCSK9', 'score': 0.42184535}], 'concepts': [{'id': 'https://openalex.org/C2777704780', 'wikidata': 'https://www.wikidata.org/wiki/Q21115210', 'display_name': 'ABCA1', 'level': 4, 'score': 0.9715562}, {'id': 'https://openalex.org/C2776330080', 'wikidata': 'https://www.wikidata.org/wiki/Q21113668', 'display_name': 'ABCG1', 'level': 5, 'score': 0.90418094}, {'id': 'https://openalex.org/C167400880', 'wikidata': 'https://www.wikidata.org/wiki/Q3454539', 'display_name': 'Liver X receptor', 'level': 5, 'score': 0.85554206}, {'id': 'https://openalex.org/C85051948', 'wikidata': 'https://www.wikidata.org/wiki/Q416064', 'display_name': 'Sterol regulatory element-binding protein', 'level': 4, 'score': 0.84832335}, {'id': 'https://openalex.org/C119056186', 'wikidata': 'https://www.wikidata.org/wiki/Q1431332', 'display_name': 'Gene silencing', 'level': 3, 'score': 0.81185746}, {'id': 'https://openalex.org/C2778718757', 'wikidata': 'https://www.wikidata.org/wiki/Q143623', 'display_name': 'Sterol', 'level': 3, 'score': 0.68153596}, {'id': 'https://openalex.org/C2778163477', 'wikidata': 'https://www.wikidata.org/wiki/Q43656', 'display_name': 'Cholesterol', 'level': 2, 'score': 0.66495156}, {'id': 'https://openalex.org/C200082930', 'wikidata': 'https://www.wikidata.org/wiki/Q22327148', 'display_name': 'Efflux', 'level': 2, 'score': 0.53804135}, {'id': 'https://openalex.org/C76591681', 'wikidata': 'https://www.wikidata.org/wiki/Q18034995', 'display_name': 'Liver X receptor alpha', 'level': 5, 'score': 0.53425324}, {'id': 'https://openalex.org/C110459506', 'wikidata': 'https://www.wikidata.org/wiki/Q7318217', 'display_name': 'Reverse cholesterol transport', 'level': 4, 'score': 0.5248354}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.48466235}, {'id': 'https://openalex.org/C149011108', 'wikidata': 'https://www.wikidata.org/wiki/Q652985', 'display_name': 'Transporter', 'level': 3, 'score': 0.43808994}, {'id': 'https://openalex.org/C43554185', 'wikidata': 'https://www.wikidata.org/wiki/Q425649', 'display_name': 'LDL receptor', 'level': 4, 'score': 0.43298426}, {'id': 'https://openalex.org/C2780948078', 'wikidata': 'https://www.wikidata.org/wiki/Q21130010', 'display_name': 'PCSK9', 'level': 5, 'score': 0.42184535}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3968219}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.3778231}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3766912}, {'id': 'https://openalex.org/C2780072125', 'wikidata': 'https://www.wikidata.org/wiki/Q28350', 'display_name': 'Lipoprotein', 'level': 3, 'score': 0.35145932}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.30175716}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.28385663}, {'id': 'https://openalex.org/C63932345', 'wikidata': 'https://www.wikidata.org/wiki/Q422500', 'display_name': 'Nuclear receptor', 'level': 4, 'score': 0.28075367}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.20347205}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.113074005}], 'mesh': [{'descriptor_ui': 'D018528', 'descriptor_name': 'ATP-Binding Cassette Transporters', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D051782', 'descriptor_name': 'Sterol Regulatory Element Binding Protein 2', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D020121', 'descriptor_name': "5' Untranslated Regions", 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020121', 'descriptor_name': "5' Untranslated Regions", 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D064286', 'descriptor_name': 'ATP Binding Cassette Transporter 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000070998', 'descriptor_name': 'ATP Binding Cassette Transporter, Subfamily G, Member 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018528', 'descriptor_name': 'ATP-Binding Cassette Transporters', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018528', 'descriptor_name': 'ATP-Binding Cassette Transporters', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002784', 'descriptor_name': 'Cholesterol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002784', 'descriptor_name': 'Cholesterol', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D002784', 'descriptor_name': 'Cholesterol', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008076', 'descriptor_name': 'Cholesterol, HDL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008076', 'descriptor_name': 'Cholesterol, HDL', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008077', 'descriptor_name': 'Lipoproteins, LDL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008077', 'descriptor_name': 'Lipoproteins, LDL', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D008077', 'descriptor_name': 'Lipoproteins, LDL', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011973', 'descriptor_name': 'Receptors, LDL', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011973', 'descriptor_name': 'Receptors, LDL', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011973', 'descriptor_name': 'Receptors, LDL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020218', 'descriptor_name': 'Response Elements', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D020218', 'descriptor_name': 'Response Elements', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051782', 'descriptor_name': 'Sterol Regulatory Element Binding Protein 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051782', 'descriptor_name': 'Sterol Regulatory Element Binding Protein 2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015533', 'descriptor_name': 'Transcriptional Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.1005191107', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2901433', 'pdf_url': 'https://europepmc.org/articles/pmc2901433?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901433', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20566875', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.1005191107', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.47, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 39, 'referenced_works': ['https://openalex.org/W120220131', 'https://openalex.org/W1650965741', 'https://openalex.org/W1964844389', 'https://openalex.org/W1975998449', 'https://openalex.org/W1981003642', 'https://openalex.org/W1982715024', 'https://openalex.org/W2003840075', 'https://openalex.org/W2006921001', 'https://openalex.org/W2009789367', 'https://openalex.org/W2020889176', 'https://openalex.org/W2023864554', 'https://openalex.org/W2025165872', 'https://openalex.org/W2030341081', 'https://openalex.org/W2039528004', 'https://openalex.org/W2039999119', 'https://openalex.org/W2041631804', 'https://openalex.org/W2056761658', 'https://openalex.org/W2057680047', 'https://openalex.org/W2061672799', 'https://openalex.org/W2064366700', 'https://openalex.org/W2071713779', 'https://openalex.org/W2075728036', 'https://openalex.org/W2093296161', 'https://openalex.org/W2094900419', 'https://openalex.org/W2098292729', 'https://openalex.org/W2102901373', 'https://openalex.org/W2109320834', 'https://openalex.org/W2127791131', 'https://openalex.org/W2127949914', 'https://openalex.org/W2144275895', 'https://openalex.org/W2147359941', 'https://openalex.org/W2149731417', 'https://openalex.org/W2155290141', 'https://openalex.org/W2157682988', 'https://openalex.org/W2162674813', 'https://openalex.org/W2247997571', 'https://openalex.org/W2615043561', 'https://openalex.org/W4256475235', 'https://openalex.org/W57115353'], 'related_works': ['https://openalex.org/W4237878070', 'https://openalex.org/W4211188852', 'https://openalex.org/W2405007220', 'https://openalex.org/W2362188974', 'https://openalex.org/W2301430970', 'https://openalex.org/W2154694480', 'https://openalex.org/W2074070774', 'https://openalex.org/W2055712591', 'https://openalex.org/W2052657737', 'https://openalex.org/W1984008992'], 'abstract_inverted_index': {'The': [0, 29], 'sterol': [1, 89], 'regulatory': [2], 'element': [3], 'binding': [4], 'protein': [5, 135], '2': [6], '(SREBP-2)': [7], 'and': [8, 23, 25, 56, 71, 87, 115, 134, 136], 'the': [9, 59, 82], 'liver': [10], 'X': [11], 'receptor': [12], '(LXR)': [13], 'control': [14], 'antagonistic': [15], 'transcriptional': [16], 'programs': [17], 'that': [18, 65, 72, 108, 131], 'stimulate': [19], 'cellular': [20], 'cholesterol': [21, 26, 48, 110], 'uptake': [22], 'synthesis,': [24], 'efflux,': [27], 'respectively.': [28], 'clinical': [30], 'importance': [31], 'of': [32, 54, 85, 144], 'SREBP-2': [33, 55, 70], 'is': [34, 67, 117], 'revealed': [35], 'in': [36, 81], 'patients': [37], 'with': [38, 41], 'hypercholesterolemia': [39], 'treated': [40], 'statins,': [42], 'which': [43], 'reduce': [44], 'low-density': [45], 'lipoprotein': [46], '(LDL)': [47], 'levels': [49, 139], 'by': [50, 98, 119, 125], 'increasing': [51], 'hepatic': [52, 142, 150], 'expression': [53], 'its': [57], 'target,': [58], 'LDL': [60], 'receptor.': [61], 'Here': [62], 'we': [63, 129], 'show': [64, 107, 130], 'miR-33': [66, 120, 126, 151], 'encoded': [68], 'within': [69], 'both': [73, 92, 113], 'mRNAs': [74], 'are': [75], 'coexpressed.': [76], 'We': [77], 'also': [78], 'identify': [79], 'sequences': [80], '3′': [83], 'UTR': [84], 'ABCA1': [86, 132], 'ABCG1,': [88], 'transporter': [90], 'genes': [91], 'previously': [93], 'shown': [94], 'to': [95, 112, 158], 'be': [96], 'regulated': [97], 'LXR,': [99], 'as': [100], 'targets': [101], 'for': [102], 'miR-33–mediated': [103], 'silencing.': [104, 127, 152], 'Our': [105], 'data': [106], 'LXR-dependent': [109], 'efflux': [111], 'ApoAI': [114], 'serum': [116], 'ameliorated': [118], 'overexpression': [121, 143], 'and,': [122], 'conversely,': [123], 'stimulated': [124], 'Finally,': [128], 'mRNA': [133], 'plasma': [137], 'HDL': [138], 'decline': [140], 'after': [141, 149], 'miR-33,': [145], 'whereas': [146], 'they': [147], 'increase': [148], 'These': [153], 'results': [154], 'suggest': [155], 'novel': [156], 'ways': [157], 'manage': [159], 'hypercholesterolemic': [160], 'patients.': [161]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2154694480', 'counts_by_year': [{'year': 2024, 'cited_by_count': 11}, {'year': 2023, 'cited_by_count': 19}, {'year': 2022, 'cited_by_count': 22}, {'year': 2021, 'cited_by_count': 39}, {'year': 2020, 'cited_by_count': 28}, {'year': 2019, 'cited_by_count': 31}, {'year': 2018, 'cited_by_count': 40}, {'year': 2017, 'cited_by_count': 33}, {'year': 2016, 'cited_by_count': 61}, {'year': 2015, 'cited_by_count': 54}, {'year': 2014, 'cited_by_count': 46}, {'year': 2013, 'cited_by_count': 63}, {'year': 2012, 'cited_by_count': 41}], 'updated_date': '2025-01-06T13:08:41.634098', 'created_date': '2016-06-24'}