Publication Information

{'id': 'https://openalex.org/W2301430970', 'doi': 'https://doi.org/10.1161/atvb.34.suppl_1.230', 'title': 'Abstract 230: Stimulation of Cholesterol Efflux from Human Macrophage by Liver X Receptor Agonists is a 2-Step Mechanism Requiring ARL7 and ABCA1', 'display_name': 'Abstract 230: Stimulation of Cholesterol Efflux from Human Macrophage by Liver X Receptor Agonists is a 2-Step Mechanism Requiring ARL7 and ABCA1', 'publication_year': 2014, 'publication_date': '2014-05-01', 'ids': {'openalex': 'https://openalex.org/W2301430970', 'doi': 'https://doi.org/10.1161/atvb.34.suppl_1.230', 'mag': '2301430970'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1161/atvb.34.suppl_1.230', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3485792', 'display_name': 'Arteriosclerosis Thrombosis and Vascular Biology', 'issn_l': '1079-5642', 'issn': ['1079-5642', '1524-4636'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5007197250', 'display_name': 'Alexandre Superville', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210154657', 'display_name': 'Fondation pour l’innovation en Cadiométabolisme et Nutrition', 'ror': 'https://ror.org/050c3pq49', 'country_code': 'FR', 'type': 'other', 'lineage': ['https://openalex.org/I4210097159', 'https://openalex.org/I4210121705', 'https://openalex.org/I4210154657']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I4210116645', 'display_name': 'Centre Alexandre Koyré', 'ror': 'https://ror.org/02dqsxz11', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I4210116645', 'https://openalex.org/I4210123595', 'https://openalex.org/I4210150854', 'https://openalex.org/I90669466']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Alexandre Superville', 'raw_affiliation_strings': ['Alexandre Superville', 'Institute of Cardiometabolism and Nutrition, INSERM UMRS 1166, Paris, France'], 'affiliations': [{'raw_affiliation_string': 'Institute of Cardiometabolism and Nutrition, INSERM UMRS 1166, Paris, France', 'institution_ids': ['https://openalex.org/I4210154657', 'https://openalex.org/I154526488']}, {'raw_affiliation_string': 'Alexandre Superville', 'institution_ids': ['https://openalex.org/I4210116645']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005734283', 'display_name': 'Éric Frisdal', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210154657', 'display_name': 'Fondation pour l’innovation en Cadiométabolisme et Nutrition', 'ror': 'https://ror.org/050c3pq49', 'country_code': 'FR', 'type': 'other', 'lineage': ['https://openalex.org/I4210097159', 'https://openalex.org/I4210121705', 'https://openalex.org/I4210154657']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Eric Frisdal', 'raw_affiliation_strings': ['Eric Frisdal', 'Institute of Cardiometabolism and Nutrition, INSERM UMRS 1166, Paris, France'], 'affiliations': [{'raw_affiliation_string': 'Eric Frisdal', 'institution_ids': []}, {'raw_affiliation_string': 'Institute of Cardiometabolism and Nutrition, INSERM UMRS 1166, Paris, France', 'institution_ids': ['https://openalex.org/I4210154657', 'https://openalex.org/I154526488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033556469', 'display_name': 'Carmel M. Quinn', 'orcid': 'https://orcid.org/0000-0003-1003-7766'}, 'institutions': [{'id': 'https://openalex.org/I31746571', 'display_name': 'UNSW Sydney', 'ror': 'https://ror.org/03r8z3t63', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I31746571']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Carmel M Quinn', 'raw_affiliation_strings': ['Carmel M Quinn', 'Cntr for Vascular Rsch, Univ of New South Wales, Sydney, Australia'], 'affiliations': [{'raw_affiliation_string': 'Cntr for Vascular Rsch, Univ of New South Wales, Sydney, Australia', 'institution_ids': ['https://openalex.org/I31746571']}, {'raw_affiliation_string': 'Carmel M Quinn', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071648630', 'display_name': 'Mi‐Jurng Kim', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I31746571', 'display_name': 'UNSW Sydney', 'ror': 'https://ror.org/03r8z3t63', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I31746571']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Mi-Jurng Kim', 'raw_affiliation_strings': ['Cntr for Vascular Rsch,, Univ of New South Wales, Sydney, Australia', 'Mi-Jurng Kim'], 'affiliations': [{'raw_affiliation_string': 'Cntr for Vascular Rsch,, Univ of New South Wales, Sydney, Australia', 'institution_ids': ['https://openalex.org/I31746571']}, {'raw_affiliation_string': 'Mi-Jurng Kim', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103538908', 'display_name': 'Wendy Jessup', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2800206598', 'display_name': 'William Jessup University', 'ror': 'https://ror.org/02wk2dc91', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I2800206598']}, {'id': 'https://openalex.org/I4210152689', 'display_name': 'Anzac Research Institute', 'ror': 'https://ror.org/05kf27764', 'country_code': 'AU', 'type': 'facility', 'lineage': ['https://openalex.org/I2801351115', 'https://openalex.org/I4210152689']}], 'countries': ['AU', 'US'], 'is_corresponding': False, 'raw_author_name': 'Wendy Jessup', 'raw_affiliation_strings': ['Atherosclerosis Laboratory, ANZAC Rsch Institute, Concord, Australia', 'Wendy Jessup'], 'affiliations': [{'raw_affiliation_string': 'Wendy Jessup', 'institution_ids': ['https://openalex.org/I2800206598']}, {'raw_affiliation_string': 'Atherosclerosis Laboratory, ANZAC Rsch Institute, Concord, Australia', 'institution_ids': ['https://openalex.org/I4210152689']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017225922', 'display_name': 'Philippe Lesnik', 'orcid': 'https://orcid.org/0000-0002-6909-7715'}, 'institutions': [{'id': 'https://openalex.org/I4210115546', 'display_name': 'Centre Hospitalier Philippe Pinel', 'ror': 'https://ror.org/024cn3w16', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210115546']}, {'id': 'https://openalex.org/I4210154657', 'display_name': 'Fondation pour l’innovation en Cadiométabolisme et Nutrition', 'ror': 'https://ror.org/050c3pq49', 'country_code': 'FR', 'type': 'other', 'lineage': ['https://openalex.org/I4210097159', 'https://openalex.org/I4210121705', 'https://openalex.org/I4210154657']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Philippe Lesnik', 'raw_affiliation_strings': ['Institute of Cardiometabolism and Nutrition, INSERM UMRS 1166, Paris, France', 'Philippe Lesnik'], 'affiliations': [{'raw_affiliation_string': 'Philippe Lesnik', 'institution_ids': ['https://openalex.org/I4210115546']}, {'raw_affiliation_string': 'Institute of Cardiometabolism and Nutrition, INSERM UMRS 1166, Paris, France', 'institution_ids': ['https://openalex.org/I4210154657', 'https://openalex.org/I154526488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000484969', 'display_name': 'Maryse Guérin', 'orcid': 'https://orcid.org/0000-0003-0150-1360'}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I4210154657', 'display_name': 'Fondation pour l’innovation en Cadiométabolisme et Nutrition', 'ror': 'https://ror.org/050c3pq49', 'country_code': 'FR', 'type': 'other', 'lineage': ['https://openalex.org/I4210097159', 'https://openalex.org/I4210121705', 'https://openalex.org/I4210154657']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Maryse Guérin', 'raw_affiliation_strings': ['Institute of Cardiometabolism and Nutrition, INSERM UMRS 1166, Paris, France'], 'affiliations': [{'raw_affiliation_string': 'Institute of Cardiometabolism and Nutrition, INSERM UMRS 1166, Paris, France', 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I4210154657']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5000346574', 'display_name': 'Wilfried Le Goff', 'orcid': 'https://orcid.org/0000-0002-7611-9644'}, 'institutions': [{'id': 'https://openalex.org/I4210154657', 'display_name': 'Fondation pour l’innovation en Cadiométabolisme et Nutrition', 'ror': 'https://ror.org/050c3pq49', 'country_code': 'FR', 'type': 'other', 'lineage': ['https://openalex.org/I4210097159', 'https://openalex.org/I4210121705', 'https://openalex.org/I4210154657']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Wilfried Le Goff', 'raw_affiliation_strings': ['Institute of Cardiometabolism and Nutrition, INSERM UMRS 1166, Paris, France', 'Wilfried Le Goff'], 'affiliations': [{'raw_affiliation_string': 'Institute of Cardiometabolism and Nutrition, INSERM UMRS 1166, Paris, France', 'institution_ids': ['https://openalex.org/I4210154657', 'https://openalex.org/I154526488']}, {'raw_affiliation_string': 'Wilfried Le Goff', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 7, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 66}, 'biblio': {'volume': '34', 'issue': 'suppl_1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11618', 'display_name': 'Cholesterol and Lipid Metabolism', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11618', 'display_name': 'Cholesterol and Lipid Metabolism', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12465', 'display_name': 'Cancer, Lipids, and Metabolism', 'score': 0.9683, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13736', 'display_name': 'Steroid Chemistry and Biochemistry', 'score': 0.9497, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/liver-x-receptor', 'display_name': 'Liver X receptor', 'score': 0.9460757}, {'id': 'https://openalex.org/keywords/abcg1', 'display_name': 'ABCG1', 'score': 0.93124634}, {'id': 'https://openalex.org/keywords/reverse-cholesterol-transport', 'display_name': 'Reverse cholesterol transport', 'score': 0.6906999}, {'id': 'https://openalex.org/keywords/efflux', 'display_name': 'Efflux', 'score': 0.6536457}, {'id': 'https://openalex.org/keywords/lipid-raft', 'display_name': 'Lipid raft', 'score': 0.4927514}], 'concepts': [{'id': 'https://openalex.org/C167400880', 'wikidata': 'https://www.wikidata.org/wiki/Q3454539', 'display_name': 'Liver X receptor', 'level': 5, 'score': 0.9460757}, {'id': 'https://openalex.org/C2777704780', 'wikidata': 'https://www.wikidata.org/wiki/Q21115210', 'display_name': 'ABCA1', 'level': 4, 'score': 0.9317969}, {'id': 'https://openalex.org/C2776330080', 'wikidata': 'https://www.wikidata.org/wiki/Q21113668', 'display_name': 'ABCG1', 'level': 5, 'score': 0.93124634}, {'id': 'https://openalex.org/C2778163477', 'wikidata': 'https://www.wikidata.org/wiki/Q43656', 'display_name': 'Cholesterol', 'level': 2, 'score': 0.71510327}, {'id': 'https://openalex.org/C110459506', 'wikidata': 'https://www.wikidata.org/wiki/Q7318217', 'display_name': 'Reverse cholesterol transport', 'level': 4, 'score': 0.6906999}, {'id': 'https://openalex.org/C200082930', 'wikidata': 'https://www.wikidata.org/wiki/Q22327148', 'display_name': 'Efflux', 'level': 2, 'score': 0.6536457}, {'id': 'https://openalex.org/C24998067', 'wikidata': 'https://www.wikidata.org/wiki/Q4114622', 'display_name': 'Stimulation', 'level': 2, 'score': 0.63718575}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5978083}, {'id': 'https://openalex.org/C76591681', 'wikidata': 'https://www.wikidata.org/wiki/Q18034995', 'display_name': 'Liver X receptor alpha', 'level': 5, 'score': 0.5008199}, {'id': 'https://openalex.org/C79266657', 'wikidata': 'https://www.wikidata.org/wiki/Q424178', 'display_name': 'Lipid raft', 'level': 3, 'score': 0.4927514}, {'id': 'https://openalex.org/C119056186', 'wikidata': 'https://www.wikidata.org/wiki/Q1431332', 'display_name': 'Gene silencing', 'level': 3, 'score': 0.49075684}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.4623204}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.4421512}, {'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.43924907}, {'id': 'https://openalex.org/C2778938600', 'wikidata': 'https://www.wikidata.org/wiki/Q389934', 'display_name': 'Agonist', 'level': 3, 'score': 0.42480576}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.38783094}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.3495525}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.34146476}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2783271}, {'id': 'https://openalex.org/C63932345', 'wikidata': 'https://www.wikidata.org/wiki/Q422500', 'display_name': 'Nuclear receptor', 'level': 4, 'score': 0.25494152}, {'id': 'https://openalex.org/C149011108', 'wikidata': 'https://www.wikidata.org/wiki/Q652985', 'display_name': 'Transporter', 'level': 3, 'score': 0.19828525}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.19778287}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.16336668}, {'id': 'https://openalex.org/C2780072125', 'wikidata': 'https://www.wikidata.org/wiki/Q28350', 'display_name': 'Lipoprotein', 'level': 3, 'score': 0.09162149}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.05525759}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.051702827}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1161/atvb.34.suppl_1.230', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3485792', 'display_name': 'Arteriosclerosis Thrombosis and Vascular Biology', 'issn_l': '1079-5642', 'issn': ['1079-5642', '1524-4636'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W2331166879', 'https://openalex.org/W2301430970', 'https://openalex.org/W2095613717', 'https://openalex.org/W2074070774', 'https://openalex.org/W2055712591', 'https://openalex.org/W2052657737', 'https://openalex.org/W2020349092', 'https://openalex.org/W1990488222', 'https://openalex.org/W1988868274', 'https://openalex.org/W1973373900'], 'abstract_inverted_index': {'Nuclear': [0], 'Liver': [1], 'X': [2], 'Receptors': [3], 'activation': [4, 292], 'by': [5, 129, 140, 195, 253, 325], 'synthetic': [6], 'agonists': [7], 'was': [8, 51, 197, 255], 'proven': [9], 'to': [10, 52, 121, 169, 174, 193, 211, 215, 229, 251, 298, 312], 'be': [11], 'atheroprotective': [12], 'in': [13, 31, 43, 115, 146, 202, 258, 269, 302], 'mice;': [14], 'an': [15, 86, 90], 'effect': [16, 87], 'likely': [17], 'based': [18], 'on': [19, 226], 'stimulation': [20, 125, 179, 189, 247, 279], 'of': [21, 48, 93, 124, 126, 133, 153, 190, 219, 248, 267, 280], 'cellular': [22, 55], 'cholesterol': [23, 33, 59, 97, 127, 154, 167, 191, 213, 227, 249, 270, 281, 296, 309], 'efflux': [24, 34, 60, 100, 128, 168, 192, 214, 228, 250, 271, 282], 'from': [25, 35, 40, 61, 231, 272, 283], 'arterial': [26], 'macrophages.': [27, 45], 'However,': [28, 217], 'mechanisms': [29, 56], 'involved': [30], 'free': [32, 58, 96, 166, 295, 308], 'mouse': [36], 'macrophages': [37, 63, 72, 238, 285], 'appear': [38], 'distinct': [39], 'those': [41, 207], 'operating': [42], 'human': [44, 62, 70, 273, 284], 'The': [46], 'objective': [47], 'this': [49, 319], 'study': [50], 'decipher': [53], 'precise': [54], 'controlling': [57], 'upon': [64, 178], 'LXR': [65, 77, 135, 243, 291], 'stimulation.': [66], 'In': [67], 'THP-1': [68, 147, 205, 237], 'and': [69, 103, 138, 148, 158, 173, 314], 'monocyte-derived': [71], '(HMDM),': [73], 'treatment': [74], 'with': [75, 89, 180, 242], 'the': [76, 264], 'agonist': [78], 'GW3965': [79, 196, 254], 'efficiently': [80], 'induced': [81], 'ARL7': [82, 116], 'expression': [83, 152], '(6-fold,': [84], 'p<0.05),': [85], 'associated': [88], 'increased': [91], 'amount': [92], 'plasma': [94, 299], 'membrane': [95, 307], 'available': [98], 'for': [99], '(+25%,': [101], 'p<0.05)': [102, 172, 177, 201], 'a': [104, 122, 287], 'higher': [105], 'lipid': [106, 303], 'rafts': [107], 'formation': [108], '(+10%,': [109], 'p<0.05).': [110], 'Both': [111], 'effects': [112], 'were': [113], 'abolished': [114, 257], 'Knockdown': [117], '(KD)': [118], 'macrophages,': [119, 262], 'leading': [120], 'lack': [123], 'GW3965.': [130], 'Specific': [131], 'targeting': [132], 'each': [134], 'isoforms,': [136], 'LXRα': [137, 144], 'LXRβ,': [139], 'RNAi': [141], 'revealed': [142], 'that': [143, 277], 'silencing': [145, 184, 218], 'HMDM': [149], 'reduced': [150, 199], 'significantly': [151, 198], 'transporters': [155], 'ABCA1,': [156], 'ABCG1': [157, 220], 'receptor': [159], 'SR-BI/Cla-1': [160], 'mRNA': [161], 'levels,': [162], 'as': [163, 165], 'well': [164], 'apoA1': [170, 313], '(-30%,': [171], 'HDL': [175, 194, 230, 252, 315], '(-20%,': [176], 'LXR,': [181], 'whereas': [182], 'LXRβ': [183], 'has': [185], 'no': [186, 224], 'impact.': [187], 'Interestingly,': [188], '(-50%,': [200], 'ABCA1': [203, 235, 268], 'KD': [204, 236, 261], 'macrophages;': [206], 'cells': [208], 'being': [209, 322], 'incapable': [210], 'promote': [212], 'apoA1.': [216], 'or': [221, 234, 240], 'SR-B1/Cla-1': [222], 'had': [223], 'impact': [225], 'either': [232], 'control': [233], 'treated': [239], 'not': [241], 'agonist.': [244], 'By': [245], 'contrast': [246], 'completely': [256], 'LXRα/ABCA1': [259], 'double': [260], 'highlighting': [263], 'major': [265], 'contribution': [266], 'macrophage.': [274], 'We': [275], 'conclude': [276], 'LXR-mediated': [278], 'is': [286, 310], 'two-steps': [288], 'mechanism.': [289], 'First,': [290], 'promotes': [293], 'ARL7-dependent': [294], 'transport': [297], 'membrane,': [300], 'mostly': [301], 'raft': [304], 'domains.': [305], 'Then,': [306], 'exported': [311], 'acceptors': [316], 'through': [317], 'ABCA1;': [318], 'latter': [320], 'step': [321], 'controlled': [323], 'selectively': [324], 'LXRα.': [326]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2301430970', 'counts_by_year': [], 'updated_date': '2025-01-07T08:23:45.050836', 'created_date': '2016-06-24'}