Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2151603894', 'doi': 'https://doi.org/10.1002/cncr.23473', 'title': 'Antiandrogen withdrawal in castrate‐refractory prostate cancer', 'display_name': 'Antiandrogen withdrawal in castrate‐refractory prostate cancer', 'publication_year': 2008, 'publication_date': '2008-03-28', 'ids': {'openalex': 'https://openalex.org/W2151603894', 'doi': 'https://doi.org/10.1002/cncr.23473', 'mag': '2151603894', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18383517', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3359896'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/cncr.23473', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S126033908', 'display_name': 'Cancer', 'issn_l': '0008-543X', 'issn': ['0008-543X', '1045-7410', '1097-0142'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'http://deepblue.lib.umich.edu/bitstream/2027.42/58635/1/23473_ftp.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5073246821', 'display_name': 'Oliver Sartor', 'orcid': 'https://orcid.org/0000-0002-8777-7343'}, 'institutions': [{'id': 'https://openalex.org/I81020160', 'display_name': 'Louisiana State University Health Sciences Center Shreveport', 'ror': 'https://ror.org/03151rh82', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I81020160']}, {'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'A. Oliver Sartor', 'raw_affiliation_strings': ['Department of Medicine, Louisiana State University Health Sciences Center, Shreveport, Louisiana', 'Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Louisiana State University Health Sciences Center, Shreveport, Louisiana', 'institution_ids': ['https://openalex.org/I81020160']}, {'raw_affiliation_string': 'Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts', 'institution_ids': ['https://openalex.org/I4210117453']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026563364', 'display_name': 'Catherine M. Tangen', 'orcid': 'https://orcid.org/0000-0001-8825-8660'}, 'institutions': [{'id': 'https://openalex.org/I4210101190', 'display_name': 'Cancer Research And Biostatistics', 'ror': 'https://ror.org/01575p865', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210101190']}, {'id': 'https://openalex.org/I4210165553', 'display_name': 'SWOG Cancer Research Network', 'ror': 'https://ror.org/05n6zrm60', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884', 'https://openalex.org/I4210165553']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Catherine M. Tangen', 'raw_affiliation_strings': ['Southwest Oncology Group Statistical Center, Seattle, Washington'], 'affiliations': [{'raw_affiliation_string': 'Southwest Oncology Group Statistical Center, Seattle, Washington', 'institution_ids': ['https://openalex.org/I4210101190', 'https://openalex.org/I4210165553']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041126882', 'display_name': 'Maha Hussain', 'orcid': 'https://orcid.org/0000-0003-0380-9465'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Maha H. A. Hussain', 'raw_affiliation_strings': ['Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012074439', 'display_name': 'Mario A. Eisenberger', 'orcid': 'https://orcid.org/0000-0002-8787-3271'}, 'institutions': [{'id': 'https://openalex.org/I4210150276', 'display_name': 'Sanofi (Mexico)', 'ror': 'https://ror.org/05wd66v55', 'country_code': 'MX', 'type': 'company', 'lineage': ['https://openalex.org/I3018075036', 'https://openalex.org/I4210150276']}, {'id': 'https://openalex.org/I4210122652', 'display_name': 'Ipsen (Spain)', 'ror': 'https://ror.org/021jz4j66', 'country_code': 'ES', 'type': 'company', 'lineage': ['https://openalex.org/I183367347', 'https://openalex.org/I4210122652']}], 'countries': ['ES', 'MX'], 'is_corresponding': False, 'raw_author_name': 'Mario A. Eisenberger', 'raw_affiliation_strings': ['Departments of Urology and Oncology, John Hopkins Oncology Center, Baltimore, Maryland', 'Mario A. Eisenberger is a consultant to and on the advisory boards of Sanofi-Aventis, Ipsen, and Celgene.'], 'affiliations': [{'raw_affiliation_string': 'Mario A. Eisenberger is a consultant to and on the advisory boards of Sanofi-Aventis, Ipsen, and Celgene.', 'institution_ids': ['https://openalex.org/I4210150276', 'https://openalex.org/I4210122652']}, {'raw_affiliation_string': 'Departments of Urology and Oncology, John Hopkins Oncology Center, Baltimore, Maryland', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017245324', 'display_name': 'Minoti Parab', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Minoti Parab', 'raw_affiliation_strings': ['Department of Family Medicine, Carolina Health Specialists, Myrtle Beach, South Carolina'], 'affiliations': [{'raw_affiliation_string': 'Department of Family Medicine, Carolina Health Specialists, Myrtle Beach, South Carolina', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039968524', 'display_name': 'Joseph A. Fontana', 'orcid': 'https://orcid.org/0000-0003-3829-3358'}, 'institutions': [{'id': 'https://openalex.org/I185443292', 'display_name': 'Wayne State University', 'ror': 'https://ror.org/01070mq45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I185443292']}, {'id': 'https://openalex.org/I2802849423', 'display_name': 'University Medical Center', 'ror': 'https://ror.org/036pt7h44', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802849423']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joseph A. Fontana', 'raw_affiliation_strings': ['Department of Medicine, Wayne State University Medical Center, Detroit, Michigan'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Wayne State University Medical Center, Detroit, Michigan', 'institution_ids': ['https://openalex.org/I185443292', 'https://openalex.org/I2802849423']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016443781', 'display_name': 'Robert A. Chapman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2803043754', 'display_name': 'Henry Ford Hospital', 'ror': 'https://ror.org/0193sb042', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I154057602', 'https://openalex.org/I2803043754']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Robert A. Chapman', 'raw_affiliation_strings': ['Department of Medical Oncolgy, Henry Ford Hospital, Detroit, Michigan'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncolgy, Henry Ford Hospital, Detroit, Michigan', 'institution_ids': ['https://openalex.org/I2803043754']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049051758', 'display_name': 'Glenn Mills', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I81020160', 'display_name': 'Louisiana State University Health Sciences Center Shreveport', 'ror': 'https://ror.org/03151rh82', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I81020160']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Glenn M. Mills', 'raw_affiliation_strings': ['Department of Medicine, Louisiana State University Health Sciences Center, Shreveport, Louisiana'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Louisiana State University Health Sciences Center, Shreveport, Louisiana', 'institution_ids': ['https://openalex.org/I81020160']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055990171', 'display_name': 'Derek Raghavan', 'orcid': 'https://orcid.org/0000-0002-7358-3994'}, 'institutions': [{'id': 'https://openalex.org/I1316902750', 'display_name': 'Cleveland Clinic', 'ror': 'https://ror.org/03xjacd83', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1316902750']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Derek Raghavan', 'raw_affiliation_strings': ['Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, Ohio'], 'affiliations': [{'raw_affiliation_string': 'Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, Ohio', 'institution_ids': ['https://openalex.org/I1316902750']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5105540602', 'display_name': 'E. David Crawford', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210087413', 'display_name': 'University of Colorado Health', 'ror': 'https://ror.org/0107w4315', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087413']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'E. David Crawford', 'raw_affiliation_strings': ['Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado'], 'affiliations': [{'raw_affiliation_string': 'Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado', 'institution_ids': ['https://openalex.org/I4210087413']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 12, 'corresponding_author_ids': ['https://openalex.org/A5073246821'], 'corresponding_institution_ids': ['https://openalex.org/I81020160', 'https://openalex.org/I4210117453'], 'apc_list': {'value': 4740, 'currency': 'USD', 'value_usd': 4740, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 6.373, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 141, 'citation_normalized_percentile': {'value': 0.999963, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '112', 'issue': '11', 'first_page': '2393', 'last_page': '2400'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10124', 'display_name': 'Prostate Cancer Diagnosis and Treatment', 'score': 0.9967, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11146', 'display_name': 'Hormonal and reproductive studies', 'score': 0.9967, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/flutamide', 'display_name': 'Flutamide', 'score': 0.81016433}, {'id': 'https://openalex.org/keywords/bicalutamide', 'display_name': 'Bicalutamide', 'score': 0.8079486}], 'concepts': [{'id': 'https://openalex.org/C2779322244', 'wikidata': 'https://www.wikidata.org/wiki/Q574820', 'display_name': 'Antiandrogen', 'level': 4, 'score': 0.95808613}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8830559}, {'id': 'https://openalex.org/C2778313021', 'wikidata': 'https://www.wikidata.org/wiki/Q418669', 'display_name': 'Flutamide', 'level': 5, 'score': 0.81016433}, {'id': 'https://openalex.org/C2780962315', 'wikidata': 'https://www.wikidata.org/wiki/Q1988832', 'display_name': 'Bicalutamide', 'level': 5, 'score': 0.8079486}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.58007956}, {'id': 'https://openalex.org/C126894567', 'wikidata': 'https://www.wikidata.org/wiki/Q105650', 'display_name': 'Urology', 'level': 1, 'score': 0.552722}, {'id': 'https://openalex.org/C2779343474', 'wikidata': 'https://www.wikidata.org/wiki/Q3109175', 'display_name': 'Context (archaeology)', 'level': 2, 'score': 0.43989208}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.37794843}, {'id': 'https://openalex.org/C141071460', 'wikidata': 'https://www.wikidata.org/wiki/Q40821', 'display_name': 'Surgery', 'level': 1, 'score': 0.32503602}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.31123734}, {'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.09236497}, {'id': 'https://openalex.org/C151730666', 'wikidata': 'https://www.wikidata.org/wiki/Q7205', 'display_name': 'Paleontology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D000726', 'descriptor_name': 'Androgen Antagonists', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D001859', 'descriptor_name': 'Bone Neoplasms', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D017430', 'descriptor_name': 'Prostate-Specific Antigen', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D013375', 'descriptor_name': 'Substance Withdrawal Syndrome', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000813', 'descriptor_name': 'Anilides', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D018572', 'descriptor_name': 'Disease-Free Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005485', 'descriptor_name': 'Flutamide', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D007987', 'descriptor_name': 'Gonadotropin-Releasing Hormone', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048289', 'descriptor_name': 'Imidazolidines', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009570', 'descriptor_name': 'Nitriles', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D009919', 'descriptor_name': 'Orchiectomy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011446', 'descriptor_name': 'Prospective Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015996', 'descriptor_name': 'Survival Rate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014105', 'descriptor_name': 'Tosyl Compounds', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/cncr.23473', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S126033908', 'display_name': 'Cancer', 'issn_l': '0008-543X', 'issn': ['0008-543X', '1045-7410', '1097-0142'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/2027.42/58635', 'pdf_url': 'http://deepblue.lib.umich.edu/bitstream/2027.42/58635/1/23473_ftp.pdf', 'source': {'id': 'https://openalex.org/S4306400393', 'display_name': 'Deep Blue (University of Michigan)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I27837315', 'host_organization_name': 'University of Michigan–Ann Arbor', 'host_organization_lineage': ['https://openalex.org/I27837315'], 'host_organization_lineage_names': ['University of Michigan–Ann Arbor'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3359896', 'pdf_url': 'https://europepmc.org/articles/pmc3359896?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359896', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/18383517', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/2027.42/58635', 'pdf_url': 'http://deepblue.lib.umich.edu/bitstream/2027.42/58635/1/23473_ftp.pdf', 'source': {'id': 'https://openalex.org/S4306400393', 'display_name': 'Deep Blue (University of Michigan)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I27837315', 'host_organization_name': 'University of Michigan–Ann Arbor', 'host_organization_lineage': ['https://openalex.org/I27837315'], 'host_organization_lineage_names': ['University of Michigan–Ann Arbor'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [{'score': 0.85, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 30, 'referenced_works': ['https://openalex.org/W122252942', 'https://openalex.org/W190198475', 'https://openalex.org/W1976637321', 'https://openalex.org/W2002810934', 'https://openalex.org/W2003985632', 'https://openalex.org/W2013614953', 'https://openalex.org/W2036951632', 'https://openalex.org/W2037234796', 'https://openalex.org/W2037934639', 'https://openalex.org/W2055825014', 'https://openalex.org/W2057714429', 'https://openalex.org/W2092991204', 'https://openalex.org/W2093514382', 'https://openalex.org/W2103090668', 'https://openalex.org/W2104422467', 'https://openalex.org/W2117296712', 'https://openalex.org/W2136456463', 'https://openalex.org/W2144841689', 'https://openalex.org/W2151545764', 'https://openalex.org/W2155679349', 'https://openalex.org/W2159778569', 'https://openalex.org/W2160064859', 'https://openalex.org/W2165611177', 'https://openalex.org/W2165631552', 'https://openalex.org/W2166912270', 'https://openalex.org/W2407462782', 'https://openalex.org/W2416163692', 'https://openalex.org/W3208750504', 'https://openalex.org/W4300619205', 'https://openalex.org/W61945152'], 'related_works': ['https://openalex.org/W4229984084', 'https://openalex.org/W3148026613', 'https://openalex.org/W2589605293', 'https://openalex.org/W2165611177', 'https://openalex.org/W2065112594', 'https://openalex.org/W2033996255', 'https://openalex.org/W2013301667', 'https://openalex.org/W2010412515', 'https://openalex.org/W1978560708', 'https://openalex.org/W1592598587'], 'abstract_inverted_index': {'Abstract': [0], 'BACKGROUND.': [1], 'Antiandrogen': [2], 'withdrawal': [3, 22, 168], 'is': [4], 'a': [5, 28, 100, 229], 'potential': [6], 'therapeutic': [7], 'maneuver': [8], 'for': [9, 176], 'patients': [10, 45, 98, 108, 123, 237], 'with': [11, 50, 178, 208], 'progressive': [12, 37], 'prostate': [13, 38], 'cancer.': [14], 'This': [15], 'study': [16, 204], 'was': [17, 144, 169, 217], 'designed': [18], 'to': [19, 65, 133, 151], 'examine': [20], 'antiandrogen': [21, 52, 167, 194, 215, 241], 'effects': [23], 'within': [24], 'the': [25, 118, 218], 'context': [26], 'of': [27, 67, 70, 80, 93, 103, 107, 122, 128, 183, 193, 222, 233, 254], 'large': [29], 'multi‐institutional': [30], 'prospective': [31], 'trial.': [32], 'METHODS.': [33], 'Eligibility': [34], 'criteria': [35], 'included': [36], 'adenocarcinoma': [39], 'despite': [40], 'combined': [41], 'androgen': [42], 'blockade.': [43], 'Eligible': [44], 'received': [46, 110], 'prior': [47, 84], 'initial': [48], 'treatment': [49], 'an': [51], 'plus': [53], 'orchiectomy': [54], 'or': [55, 75, 78, 158], 'luteinizing': [56], 'hormone‐releasing': [57], 'hormone': [58], '(LHRH)': [59], 'agonist.': [60], 'Patients': [61], 'were': [62, 138, 206, 239], 'stratified': [63], 'according': [64], 'type': [66, 69], 'antiandrogen,': [68], 'progression': [71, 202], '(prostate‐specific': [72], 'antigen': [73], '[PSA]': [74], 'radiographic),': [76], 'presence': [77], 'absence': [79], 'metastatic': [81, 184], 'disease,': [82, 185], 'and': [83, 96, 114, 173, 179, 200, 212], 'LHRH': [85], 'agonist': [86], 'versus': [87], 'surgical': [88], 'castration.': [89], 'RESULTS.': [90], 'A': [91], 'total': [92], '210': [94, 119], 'eligible': [95], 'evaluable': [97], 'had': [99, 124, 156], 'median': [101], 'follow‐up': [102], '5.0': [104], 'years;': [105], '64%': [106], 'previously': [109], 'flutamide,': [111], '32%': [112], 'bicalutamide,': [113], '3%': [115], 'nilutamide.': [116], 'Of': [117], 'patients,': [120], '21%': [121], 'confirmed': [125], 'PSA': [126, 197, 223, 234], 'decreases': [127], '≥50%': [129], '(95%': [130, 147], 'CI,': [131, 148], '16%': [132], '27%).': [134], 'No': [135], 'radiographic': [136, 181], 'responses': [137], 'recorded.': [139], 'Median': [140, 162], 'progression‐free': [141, 160], 'survival': [142, 164], '(PFS)': [143], '3': [145], 'months': [146, 150, 171, 175], '2': [149], '4': [152], 'months);': [153], 'however,': [154, 243], '19%': [155, 253], '12‐month': [157], 'greater': [159], 'intervals.': [161], 'overall': [163], '(OS)': [165], 'after': [166], '22': [170], '(20': [172], '40': [174], 'those': [177], 'without': [180], 'evidence': [182], 'respectively).': [186], 'Multivariate': [187], 'analyses': [188], 'indicated': [189], 'that': [190], 'longer': [191, 210], 'duration': [192], 'use,': [195], 'lower': [196], 'at': [198, 203], 'baseline,': [199], 'PSA‐only': [201], 'entry': [205], 'associated': [207], 'both': [209], 'PFS': [211, 244], 'OS.': [213], 'Longer': [214], 'use': [216], 'only': [219], 'significant': [220], 'predictor': [221], 'response.': [224], 'CONCLUSIONS.': [225], 'These': [226], 'data': [227], 'indicate': [228], 'relatively': [230, 247], 'modest': [231], 'rate': [232], 'response': [235], 'in': [236, 251], 'who': [238], 'undergoing': [240], 'withdrawal;': [242], 'can': [245], 'be': [246], 'prolonged': [248], '(≥1': [249], 'year)': [250], 'approximately': [252], 'patients.': [255], 'Cancer': [256, 261], '2008.': [257], '©': [258], '2008': [259], 'American': [260], 'Society.': [262]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2151603894', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 9}, {'year': 2017, 'cited_by_count': 9}, {'year': 2016, 'cited_by_count': 11}, {'year': 2015, 'cited_by_count': 13}, {'year': 2014, 'cited_by_count': 19}, {'year': 2013, 'cited_by_count': 15}, {'year': 2012, 'cited_by_count': 19}], 'updated_date': '2024-12-12T19:49:02.996475', 'created_date': '2016-06-24'}