Publication Information

{'id': 'https://openalex.org/W1592598587', 'doi': 'https://doi.org/10.1111/j.1442-2042.2007.01681.x', 'title': 'Effects of flutamide as a second‐line agent for maximum androgen blockade of hormone refractory prostate cancer', 'display_name': 'Effects of flutamide as a second‐line agent for maximum androgen blockade of hormone refractory prostate cancer', 'publication_year': 2007, 'publication_date': '2007-03-01', 'ids': {'openalex': 'https://openalex.org/W1592598587', 'doi': 'https://doi.org/10.1111/j.1442-2042.2007.01681.x', 'mag': '1592598587', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17430272'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1442-2042.2007.01681.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S134892809', 'display_name': 'International Journal of Urology', 'issn_l': '0919-8172', 'issn': ['0919-8172', '1442-2042'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5108691058', 'display_name': 'Kenji Nishimura', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210154519', 'display_name': 'Hyogo Prefectural Nishinomiya Hospital', 'ror': 'https://ror.org/04xhnr923', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210154519']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kenji Nishimura', 'raw_affiliation_strings': ['Department of Urology, Hyogo Prefectural Nishinomiya Hospital, Nishinomiya, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, Hyogo Prefectural Nishinomiya Hospital, Nishinomiya, Japan', 'institution_ids': ['https://openalex.org/I4210154519']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059410766', 'display_name': 'Naoko Arichi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210154519', 'display_name': 'Hyogo Prefectural Nishinomiya Hospital', 'ror': 'https://ror.org/04xhnr923', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210154519']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Naoko Arichi', 'raw_affiliation_strings': ['Department of Urology, Hyogo Prefectural Nishinomiya Hospital, Nishinomiya, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, Hyogo Prefectural Nishinomiya Hospital, Nishinomiya, Japan', 'institution_ids': ['https://openalex.org/I4210154519']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076759658', 'display_name': 'S. Tokugawa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210154519', 'display_name': 'Hyogo Prefectural Nishinomiya Hospital', 'ror': 'https://ror.org/04xhnr923', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210154519']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shigeki Tokugawa', 'raw_affiliation_strings': ['Department of Urology, Hyogo Prefectural Nishinomiya Hospital, Nishinomiya, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, Hyogo Prefectural Nishinomiya Hospital, Nishinomiya, Japan', 'institution_ids': ['https://openalex.org/I4210154519']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050522887', 'display_name': 'Iwao Yoshioka', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210154519', 'display_name': 'Hyogo Prefectural Nishinomiya Hospital', 'ror': 'https://ror.org/04xhnr923', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210154519']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Iwao Yoshioka', 'raw_affiliation_strings': ['Department of Urology, Hyogo Prefectural Nishinomiya Hospital, Nishinomiya, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, Hyogo Prefectural Nishinomiya Hospital, Nishinomiya, Japan', 'institution_ids': ['https://openalex.org/I4210154519']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108634781', 'display_name': 'Hidefumi Kishikawa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210154519', 'display_name': 'Hyogo Prefectural Nishinomiya Hospital', 'ror': 'https://ror.org/04xhnr923', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210154519']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hidefumi Kishikawa', 'raw_affiliation_strings': ['Department of Urology, Hyogo Prefectural Nishinomiya Hospital, Nishinomiya, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, Hyogo Prefectural Nishinomiya Hospital, Nishinomiya, Japan', 'institution_ids': ['https://openalex.org/I4210154519']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5035283083', 'display_name': 'Yasuji Ichikawa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210154519', 'display_name': 'Hyogo Prefectural Nishinomiya Hospital', 'ror': 'https://ror.org/04xhnr923', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210154519']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yasuji Ichikawa', 'raw_affiliation_strings': ['Department of Urology, Hyogo Prefectural Nishinomiya Hospital, Nishinomiya, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Urology, Hyogo Prefectural Nishinomiya Hospital, Nishinomiya, Japan', 'institution_ids': ['https://openalex.org/I4210154519']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3400, 'currency': 'USD', 'value_usd': 3400, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.596, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 29, 'citation_normalized_percentile': {'value': 0.897638, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '14', 'issue': '3', 'first_page': '264', 'last_page': '267'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11146', 'display_name': 'Hormonal and reproductive studies', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10124', 'display_name': 'Prostate Cancer Diagnosis and Treatment', 'score': 0.9965, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/flutamide', 'display_name': 'Flutamide', 'score': 0.98089635}, {'id': 'https://openalex.org/keywords/bicalutamide', 'display_name': 'Bicalutamide', 'score': 0.9790614}, {'id': 'https://openalex.org/keywords/refractory', 'display_name': 'Refractory (planetary science)', 'score': 0.42407608}], 'concepts': [{'id': 'https://openalex.org/C2778313021', 'wikidata': 'https://www.wikidata.org/wiki/Q418669', 'display_name': 'Flutamide', 'level': 5, 'score': 0.98089635}, {'id': 'https://openalex.org/C2780962315', 'wikidata': 'https://www.wikidata.org/wiki/Q1988832', 'display_name': 'Bicalutamide', 'level': 5, 'score': 0.9790614}, {'id': 'https://openalex.org/C2779322244', 'wikidata': 'https://www.wikidata.org/wiki/Q574820', 'display_name': 'Antiandrogen', 'level': 4, 'score': 0.90323293}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8597651}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.7127643}, {'id': 'https://openalex.org/C2778468042', 'wikidata': 'https://www.wikidata.org/wiki/Q273976', 'display_name': 'Blockade', 'level': 3, 'score': 0.61759955}, {'id': 'https://openalex.org/C126894567', 'wikidata': 'https://www.wikidata.org/wiki/Q105650', 'display_name': 'Urology', 'level': 1, 'score': 0.5798963}, {'id': 'https://openalex.org/C2777911890', 'wikidata': 'https://www.wikidata.org/wiki/Q62614', 'display_name': 'Androgen', 'level': 3, 'score': 0.55185795}, {'id': 'https://openalex.org/C2776235491', 'wikidata': 'https://www.wikidata.org/wiki/Q9625', 'display_name': 'Prostate', 'level': 3, 'score': 0.49557245}, {'id': 'https://openalex.org/C2781406297', 'wikidata': 'https://www.wikidata.org/wiki/Q409450', 'display_name': 'Prostate-specific antigen', 'level': 4, 'score': 0.48068509}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.4722421}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.4695286}, {'id': 'https://openalex.org/C142424586', 'wikidata': 'https://www.wikidata.org/wiki/Q7307572', 'display_name': 'Refractory (planetary science)', 'level': 2, 'score': 0.42407608}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.42080784}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.3226896}, {'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.26646554}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.044988126}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.04341334}, {'id': 'https://openalex.org/C87355193', 'wikidata': 'https://www.wikidata.org/wiki/Q411', 'display_name': 'Astrobiology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000726', 'descriptor_name': 'Androgen Antagonists', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D005485', 'descriptor_name': 'Flutamide', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000726', 'descriptor_name': 'Androgen Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000813', 'descriptor_name': 'Anilides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000813', 'descriptor_name': 'Anilides', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D018931', 'descriptor_name': 'Antineoplastic Agents, Hormonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018931', 'descriptor_name': 'Antineoplastic Agents, Hormonal', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D001707', 'descriptor_name': 'Biopsy, Needle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004359', 'descriptor_name': 'Drug Therapy, Combination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019160', 'descriptor_name': 'Endosonography', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005485', 'descriptor_name': 'Flutamide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005500', 'descriptor_name': 'Follow-Up Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007987', 'descriptor_name': 'Gonadotropin-Releasing Hormone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007987', 'descriptor_name': 'Gonadotropin-Releasing Hormone', 'qualifier_ui': 'Q000819', 'qualifier_name': 'agonists', 'is_major_topic': False}, {'descriptor_ui': 'D017273', 'descriptor_name': 'Goserelin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017273', 'descriptor_name': 'Goserelin', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016729', 'descriptor_name': 'Leuprolide', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D016729', 'descriptor_name': 'Leuprolide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008279', 'descriptor_name': 'Magnetic Resonance Imaging', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009367', 'descriptor_name': 'Neoplasm Staging', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009570', 'descriptor_name': 'Nitriles', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D009570', 'descriptor_name': 'Nitriles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017430', 'descriptor_name': 'Prostate-Specific Antigen', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D017430', 'descriptor_name': 'Prostate-Specific Antigen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012189', 'descriptor_name': 'Retrospective Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014057', 'descriptor_name': 'Tomography, X-Ray Computed', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014105', 'descriptor_name': 'Tosyl Compounds', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D014105', 'descriptor_name': 'Tosyl Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1442-2042.2007.01681.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S134892809', 'display_name': 'International Journal of Urology', 'issn_l': '0919-8172', 'issn': ['0919-8172', '1442-2042'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17430272', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.86}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 10, 'referenced_works': ['https://openalex.org/W2014145760', 'https://openalex.org/W2019053369', 'https://openalex.org/W2026830074', 'https://openalex.org/W2034424013', 'https://openalex.org/W2078814775', 'https://openalex.org/W2082677806', 'https://openalex.org/W2105922775', 'https://openalex.org/W2134080318', 'https://openalex.org/W2156408482', 'https://openalex.org/W2464502417'], 'related_works': ['https://openalex.org/W4229984084', 'https://openalex.org/W3148026613', 'https://openalex.org/W2589605293', 'https://openalex.org/W2165611177', 'https://openalex.org/W2065112594', 'https://openalex.org/W2033996255', 'https://openalex.org/W2013301667', 'https://openalex.org/W2010412515', 'https://openalex.org/W1978560708', 'https://openalex.org/W1592598587'], 'abstract_inverted_index': {'Abstract:': [0], 'We': [1, 96], 'analyzed': [2], 'clinical': [3], 'effects': [4], 'of': [5, 68, 87, 94, 107, 117, 135, 150, 195], 'flutamide': [6, 59, 175, 209], 'as': [7, 25, 63, 84, 130, 177], 'a': [8, 85, 112, 122, 147, 156, 178, 192], 'second‐line': [9, 64, 161, 179, 213], 'agent': [10], 'for': [11, 52, 188], 'maximum': [12], 'androgen': [13], 'blockade': [14], '(MAB)': [15], 'in': [16, 75, 114], 'patients': [17, 34, 110, 167], 'with': [18, 35, 45, 81, 173], 'relapsing': [19], 'prostate': [20, 37, 165], 'cancer': [21, 38, 166], 'who': [22, 39, 145, 168, 190], 'received': [23], 'bicalutamide': [24, 46], 'the': [26, 92, 108, 198], 'first‐line': [27, 43, 153, 171, 199], 'MAB': [28, 154, 172, 207], 'agent.': [29], 'This': [30], 'study': [31], 'included': [32], '13': [33, 109], 'progressive': [36], 'had': [40, 121, 146, 155], 'relapsed': [41], 'after': [42], 'MAB,': [44], 'at': [47, 60], '80': [48], 'mg/day.': [49], 'After': [50], 'checking': [51], 'antiandrogen': [53, 180], 'withdrawal': [54], 'syndrome,': [55], 'they': [56], 'were': [57, 128], 'given': [58], '375': [61], 'mg/day': [62], 'MAB.': [65, 162, 200], 'The': [66, 132], 'effectiveness': [67], 'that': [69, 206], 'therapy': [70], 'was': [71, 138, 181], 'evaluated': [72], 'by': [73], 'changes': [74], 'prostatic': [76], 'specific': [77], 'antigen': [78], '(PSA)': [79], 'levels,': [80, 116], 'response': [82, 137, 151, 159, 196], 'defined': [83, 129], 'decrease': [86, 113, 126], 'greater': [88, 123, 158], 'than': [89, 124], '50%': [90, 125], 'from': [91], 'start': [93], 'therapy.': [95, 215], 'also': [97], 'compared': [98], 'several': [99], 'factors': [100], 'between': [101], 'responders': [102], 'and': [103, 127], 'non‐responders.': [104], 'Nine': [105], '(69.2%)': [106], 'showed': [111, 191], 'PSA': [115, 136], 'whom': [118], 'five': [119], '(38.5%)': [120], 'responders.': [131], 'median': [133], 'duration': [134, 149, 194], '11.0': [139], 'months': [140], '(range': [141], '5–20': [142], 'months).': [143], 'Patients': [144], 'longer': [148, 193], 'to': [152, 160, 183, 197], 'significantly': [157], 'For': [163], 'advanced': [164], 'progressed': [169], 'on': [170], 'bicalutamide,': [174], 'administration': [176], 'found': [182], 'be': [184], 'relatively': [185], 'effective,': [186], 'especially': [187], 'those': [189], 'Our': [201], 'results': [202], 'confirm': [203], 'previous': [204], 'findings': [205], 'using': [208], 'is': [210], 'an': [211], 'effective': [212], 'hormonal': [214]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1592598587', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-09T08:36:53.202221', 'created_date': '2016-06-24'}