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[52], 'involving': [53], 'heart': [54, 95, 102], 'skeletal': [56], 'muscles.': [57], 'Moreover,': [58], 'well‐known': [60], 'disease': [61], 'called': [62], 'Hutchinson–Gilford': [63], 'Progeria': [64], 'Syndrome': [65], 'due': [66], 'extensive': [68], 'gene,': [72], 'addition': [74], 'systemic': [77], 'phenotype': [78], 'premature': [80], 'aging,': [81], 'characterised': [83], 'by': [84, 191], 'death': [86], 'patients': [88], 'at': [89], 'around': [90], '13': [91], 'typically': [92], 'for': [93], 'attack': [96], 'or': [97], 'stroke,': [98], 'again': [100], 'as': [103], 'main': [105], 'site': [106], 'sensitive': [107], 'disfunction.': [111], 'Indeed,': [112], 'identification': [114], 'roles': [117, 136], 'function': [124, 172], 'key': [127], 'area': [128], 'exploration.': [130], 'One': [131], 'primary': [134], 'biological': [135], 'recently': [137], 'conferred': [138], 'affect': [144], 'contractile': [145], 'cells': [146], 'lineage': [147], 'determination': [148], 'senescence.': [150], 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