Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2133617154', 'doi': 'https://doi.org/10.1124/jpet.106.111237', 'title': 'Inhibition of Nicotine Metabolism by Methoxysalen: Pharmacokinetic and Pharmacological Studies in Mice', 'display_name': 'Inhibition of Nicotine Metabolism by Methoxysalen: Pharmacokinetic and Pharmacological Studies in Mice', 'publication_year': 2006, 'publication_date': '2006-10-04', 'ids': {'openalex': 'https://openalex.org/W2133617154', 'doi': 'https://doi.org/10.1124/jpet.106.111237', 'mag': '2133617154', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17021260'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1124/jpet.106.111237', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S102125482', 'display_name': 'Journal of Pharmacology and Experimental Therapeutics', 'issn_l': '0022-3565', 'issn': ['0022-3565', '1521-0103'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316283', 'host_organization_name': 'American Society for Pharmacology and Experimental Therapeutics', 'host_organization_lineage': ['https://openalex.org/P4310316283'], 'host_organization_lineage_names': ['American Society for Pharmacology and Experimental Therapeutics'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5036036065', 'display_name': 'M. Imad Damaj', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I72019824', 'display_name': 'Virginia Commonwealth University Medical Center', 'ror': 'https://ror.org/057xmsr27', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I72019824']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'M. I. Damaj', 'raw_affiliation_strings': ['Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Box 980613, Richmond, VA 23298-0613, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Box 980613, Richmond, VA 23298-0613, USA', 'institution_ids': ['https://openalex.org/I72019824']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040608063', 'display_name': 'Eric Siu', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'E. C. K. Siu', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013791504', 'display_name': 'Edward M. Sellers', 'orcid': 'https://orcid.org/0000-0002-0669-2373'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'E. M. Sellers', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060841302', 'display_name': 'Rachel F. Tyndale', 'orcid': 'https://orcid.org/0000-0003-1297-2053'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'R. F. Tyndale', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5108459067', 'display_name': 'Billy R. Martin', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'B. R. Martin', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.477, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 33, 'citation_normalized_percentile': {'value': 0.802231, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '320', 'issue': '1', 'first_page': '250', 'last_page': '257'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11818', 'display_name': 'Nicotinic Acetylcholine Receptors Study', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11818', 'display_name': 'Nicotinic Acetylcholine Receptors Study', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13160', 'display_name': 'Synthesis and Biological Evaluation', 'score': 0.9974, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/methoxsalen', 'display_name': 'Methoxsalen', 'score': 0.83901274}], 'concepts': [{'id': 'https://openalex.org/C2779547902', 'wikidata': 'https://www.wikidata.org/wiki/Q28086552', 'display_name': 'Nicotine', 'level': 2, 'score': 0.9445846}, {'id': 'https://openalex.org/C2779175014', 'wikidata': 'https://www.wikidata.org/wiki/Q408570', 'display_name': 'Methoxsalen', 'level': 3, 'score': 0.83901274}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.8312513}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.66789985}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.6203227}, {'id': 'https://openalex.org/C112705442', 'wikidata': 'https://www.wikidata.org/wiki/Q323936', 'display_name': 'Pharmacokinetics', 'level': 2, 'score': 0.5718873}, {'id': 'https://openalex.org/C62231903', 'wikidata': 'https://www.wikidata.org/wiki/Q1057', 'display_name': 'Metabolism', 'level': 2, 'score': 0.44349357}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.21724927}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.19189465}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.17845452}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.14950576}, {'id': 'https://openalex.org/C2780564577', 'wikidata': 'https://www.wikidata.org/wiki/Q179945', 'display_name': 'Psoriasis', 'level': 2, 'score': 0.11028078}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.052981317}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001189', 'descriptor_name': 'Aryl Hydrocarbon Hydroxylases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D008730', 'descriptor_name': 'Methoxsalen', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D006899', 'descriptor_name': 'Mixed Function Oxygenases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D009538', 'descriptor_name': 'Nicotine', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001189', 'descriptor_name': 'Aryl Hydrocarbon Hydroxylases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003367', 'descriptor_name': 'Cotinine', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D003367', 'descriptor_name': 'Cotinine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D065637', 'descriptor_name': 'Cytochrome P-450 CYP2A6', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072467', 'descriptor_name': 'Cytochrome P450 Family 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008730', 'descriptor_name': 'Methoxsalen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008813', 'descriptor_name': 'Mice, Inbred ICR', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008861', 'descriptor_name': 'Microsomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008861', 'descriptor_name': 'Microsomes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006899', 'descriptor_name': 'Mixed Function Oxygenases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009538', 'descriptor_name': 'Nicotine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D009538', 'descriptor_name': 'Nicotine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010084', 'descriptor_name': 'Oxidation-Reduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1124/jpet.106.111237', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S102125482', 'display_name': 'Journal of Pharmacology and Experimental Therapeutics', 'issn_l': '0022-3565', 'issn': ['0022-3565', '1521-0103'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316283', 'host_organization_name': 'American Society for Pharmacology and Experimental Therapeutics', 'host_organization_lineage': ['https://openalex.org/P4310316283'], 'host_organization_lineage_names': ['American Society for Pharmacology and Experimental Therapeutics'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17021260', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.67}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 31, 'referenced_works': ['https://openalex.org/W1838732593', 'https://openalex.org/W1867313983', 'https://openalex.org/W1938084083', 'https://openalex.org/W1963675326', 'https://openalex.org/W1963994399', 'https://openalex.org/W1981217835', 'https://openalex.org/W1987502189', 'https://openalex.org/W1987867942', 'https://openalex.org/W1991912173', 'https://openalex.org/W1992120911', 'https://openalex.org/W2001565143', 'https://openalex.org/W2006643633', 'https://openalex.org/W2007281876', 'https://openalex.org/W2032491398', 'https://openalex.org/W2039748447', 'https://openalex.org/W2044196805', 'https://openalex.org/W2049324875', 'https://openalex.org/W2056617807', 'https://openalex.org/W2059978315', 'https://openalex.org/W2074464806', 'https://openalex.org/W2083243707', 'https://openalex.org/W2106933588', 'https://openalex.org/W2111761092', 'https://openalex.org/W2117343856', 'https://openalex.org/W2118392101', 'https://openalex.org/W2121888318', 'https://openalex.org/W2122894113', 'https://openalex.org/W2131356514', 'https://openalex.org/W2206043426', 'https://openalex.org/W2264449916', 'https://openalex.org/W2415034427'], 'related_works': ['https://openalex.org/W2315729517', 'https://openalex.org/W2133617154', 'https://openalex.org/W2090356052', 'https://openalex.org/W2074255357', 'https://openalex.org/W2035618520', 'https://openalex.org/W2027373380', 'https://openalex.org/W2022811442', 'https://openalex.org/W1990635175', 'https://openalex.org/W1988682737', 'https://openalex.org/W1977984478'], 'abstract_inverted_index': {'Studies': [0], 'were': [1, 25], 'undertaken': [2], 'to': [3, 29, 137, 194, 231], 'examine': [4], 'whether': [5, 31], 'methoxsalen': [6, 32, 52, 84, 121, 149, 186], '(9-methoxyfuro[3,2-g][1]benzopyran-7-one),': [7], 'a': [8, 72, 107, 153, 209], 'specific': [9], 'and': [10, 38, 42, 94, 118, 130, 199, 218], 'relatively': [11], 'selective': [12], 'inhibitor': [13], 'of': [14, 74, 83, 90, 114, 127, 156, 171, 192, 223, 229], 'human': [15, 68], 'CYP2A6,': [16], 'inhibited': [17], 'CYP2A5-mediated': [18], 'nicotine': [19, 36, 57, 91, 115, 157, 172, 193, 216, 224, 233], 'metabolism': [20, 58, 217], 'in': [21, 27, 44, 55, 59, 67, 110, 145, 160, 168, 197, 200, 215], 'vitro.': [22], 'Furthermore,': [23, 142], 'studies': [24], 'performed': [26], 'vivo': [28], 'determine': [30], 'would': [33], 'modulate': [34], 'acute': [35], 'pharmacokinetics': [37], 'pharmacological': [39, 112, 178], 'effects': [40, 113, 147], '(antinociception': [41], 'hypothermia)': [43], 'the': [45, 87, 99, 111, 125, 169, 190, 227], 'ICR': [46], 'mouse.': [47], 'Our': [48], 'results': [49, 183], 'demonstrated': [50], 'that': [51, 81, 166, 185, 205], 'competitively': [53], 'inhibits': [54], 'vitro': [56, 198], 'mice.': [60, 161], 'The': [61], 'inhibition': [62, 69], 'was': [63, 106, 150], 'potent,': [64], 'as': [65], 'seen': [66], 'studies,': [70], 'with': [71, 102, 152], '<i>K</i><sub>i</sub>': [73], '0.32': [75], 'μM.': [76], 'In': [77, 180], 'addition,': [78], 'we': [79], 'found': [80], 'administration': [82], 'significantly': [85], 'increased': [86, 95], 'plasma': [88, 158], 'half-life': [89], '(approximately': [92], 'doubled)': [93], 'its': [96, 219], 'area': [97], 'under': [98], 'curve': [100], 'compared': [101], 'saline': [103], 'treatment.': [104, 122], 'There': [105], 'dose-dependent': [108], 'enhancement': [109], '(body': [116], 'temperature': [117], 'analgesia)': [119], 'after': [120, 148], 'Methoxsalen': [123], 'prolonged': [124], 'duration': [126], 'nicotine-induced': [128], 'antinociception': [129], 'hypothermia': [131], '(2.5': [132], 'mg/kg)': [133], 'for': [134, 212], 'periods': [135], 'up': [136], '180': [138], 'min': [139], 'postnicotine': [140], 'administration.': [141], 'this': [143], 'prolongation': [144, 155], 'nicotine9s': [146, 177], 'associated': [151], 'parallel': [154], 'levels': [159], 'These': [162], 'data': [163], 'strongly': [164], 'suggest': [165, 204], 'variation': [167, 214], 'rates': [170], 'metabolic': [173], 'inactivation': [174], 'substantially': [175], 'alter': [176], 'effects.': [179], 'conclusion,': [181], 'these': [182], 'confirmed': [184], 'did': [187], 'indeed': [188], 'inhibit': [189], 'conversion': [191], 'cotinine': [195], 'both': [196], 'vivo.': [201], 'They': [202], 'also': [203], 'mice': [206], 'may': [207], 'represent': [208], 'suitable': [210], 'model': [211], 'studying': [213], 'impact': [220], 'on': [221], 'mechanisms': [222], 'dependence,': [225], 'including': [226], 'use': [228], 'inhibitors': [230], 'reduce': [232], 'metabolism.': [234]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2133617154', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 4}], 'updated_date': '2024-12-08T17:45:08.840245', 'created_date': '2016-06-24'}