Publication Information

{'id': 'https://openalex.org/W2090356052', 'doi': 'https://doi.org/10.1038/clpt.1987.209', 'title': 'Methoxsalen is a potent inhibitor of the metabolism of caffeine in humans', 'display_name': 'Methoxsalen is a potent inhibitor of the metabolism of caffeine in humans', 'publication_year': 1987, 'publication_date': '1987-12-01', 'ids': {'openalex': 'https://openalex.org/W2090356052', 'doi': 'https://doi.org/10.1038/clpt.1987.209', 'mag': '2090356052', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/3690940'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/clpt.1987.209', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S159852663', 'display_name': 'Clinical Pharmacology & Therapeutics', 'issn_l': '0009-9236', 'issn': ['0009-9236', '1085-8733', '1532-6535'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5108208037', 'display_name': 'Dennis C. Mays', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I52357470', 'display_name': 'The Ohio State University', 'ror': 'https://ror.org/00rs6vg23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I52357470']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Dennis C Mays', 'raw_affiliation_strings': ['Department of Pharmacology, Ohio State University, Columbus 43210.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology, Ohio State University, Columbus 43210.', 'institution_ids': ['https://openalex.org/I52357470']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062058551', 'display_name': 'Charles Camisa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I52357470', 'display_name': 'The Ohio State University', 'ror': 'https://ror.org/00rs6vg23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I52357470']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Charles Camisa', 'raw_affiliation_strings': ['Departments of Pharmacology and Medicine, College of Medicine The Ohio State University'], 'affiliations': [{'raw_affiliation_string': 'Departments of Pharmacology and Medicine, College of Medicine The Ohio State University', 'institution_ids': ['https://openalex.org/I52357470']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113649582', 'display_name': 'Paivi Cheney', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I52357470', 'display_name': 'The Ohio State University', 'ror': 'https://ror.org/00rs6vg23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I52357470']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Paivi Cheney', 'raw_affiliation_strings': ['Departments of Pharmacology and Medicine, College of Medicine The Ohio State University'], 'affiliations': [{'raw_affiliation_string': 'Departments of Pharmacology and Medicine, College of Medicine The Ohio State University', 'institution_ids': ['https://openalex.org/I52357470']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011218022', 'display_name': 'C M Pacula', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I52357470', 'display_name': 'The Ohio State University', 'ror': 'https://ror.org/00rs6vg23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I52357470']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christine M Pacula', 'raw_affiliation_strings': ['Departments of Pharmacology and Medicine, College of Medicine The Ohio State University'], 'affiliations': [{'raw_affiliation_string': 'Departments of Pharmacology and Medicine, College of Medicine The Ohio State University', 'institution_ids': ['https://openalex.org/I52357470']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012105438', 'display_name': 'S Nawoot', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I52357470', 'display_name': 'The Ohio State University', 'ror': 'https://ror.org/00rs6vg23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I52357470']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sopone Nawoot', 'raw_affiliation_strings': ['Departments of Pharmacology and Medicine, College of Medicine The Ohio State University'], 'affiliations': [{'raw_affiliation_string': 'Departments of Pharmacology and Medicine, College of Medicine The Ohio State University', 'institution_ids': ['https://openalex.org/I52357470']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5009590404', 'display_name': 'Nicolas Gerber', 'orcid': 'https://orcid.org/0000-0003-0308-699X'}, 'institutions': [{'id': 'https://openalex.org/I52357470', 'display_name': 'The Ohio State University', 'ror': 'https://ror.org/00rs6vg23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I52357470']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nicholas Gerber', 'raw_affiliation_strings': ['Departments of Pharmacology and Medicine, College of Medicine The Ohio State University'], 'affiliations': [{'raw_affiliation_string': 'Departments of Pharmacology and Medicine, College of Medicine The Ohio State University', 'institution_ids': ['https://openalex.org/I52357470']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4000, 'currency': 'USD', 'value_usd': 4000, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.781, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 28, 'citation_normalized_percentile': {'value': 0.821124, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '42', 'issue': '6', 'first_page': '621', 'last_page': '626'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11264', 'display_name': 'Coffee research and impacts', 'score': 0.991, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11264', 'display_name': 'Coffee research and impacts', 'score': 0.991, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10854', 'display_name': 'Bipolar Disorder and Treatment', 'score': 0.9627, 'subfield': {'id': 'https://openalex.org/subfields/2738', 'display_name': 'Psychiatry and Mental health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13127', 'display_name': 'Biotin and Related Studies', 'score': 0.9381, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/methoxsalen', 'display_name': 'Methoxsalen', 'score': 0.9800801}], 'concepts': [{'id': 'https://openalex.org/C2779175014', 'wikidata': 'https://www.wikidata.org/wiki/Q408570', 'display_name': 'Methoxsalen', 'level': 3, 'score': 0.9800801}, {'id': 'https://openalex.org/C2778500429', 'wikidata': 'https://www.wikidata.org/wiki/Q60235', 'display_name': 'Caffeine', 'level': 2, 'score': 0.83861667}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.7971116}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.6789303}, {'id': 'https://openalex.org/C112705442', 'wikidata': 'https://www.wikidata.org/wiki/Q323936', 'display_name': 'Pharmacokinetics', 'level': 2, 'score': 0.6202414}, {'id': 'https://openalex.org/C2777056448', 'wikidata': 'https://www.wikidata.org/wiki/Q285166', 'display_name': 'Oral administration', 'level': 2, 'score': 0.6124672}, {'id': 'https://openalex.org/C2777477808', 'wikidata': 'https://www.wikidata.org/wiki/Q407595', 'display_name': 'Metabolite', 'level': 2, 'score': 0.4414837}, {'id': 'https://openalex.org/C62231903', 'wikidata': 'https://www.wikidata.org/wiki/Q1057', 'display_name': 'Metabolism', 'level': 2, 'score': 0.4230539}, {'id': 'https://openalex.org/C2780564577', 'wikidata': 'https://www.wikidata.org/wiki/Q179945', 'display_name': 'Psoriasis', 'level': 2, 'score': 0.3060835}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.26864606}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.20649543}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.18205544}, {'id': 'https://openalex.org/C16005928', 'wikidata': 'https://www.wikidata.org/wiki/Q171171', 'display_name': 'Dermatology', 'level': 1, 'score': 0.061270088}], 'mesh': [{'descriptor_ui': 'D002110', 'descriptor_name': 'Caffeine', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': True}, {'descriptor_ui': 'D008730', 'descriptor_name': 'Methoxsalen', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001711', 'descriptor_name': 'Biotransformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002110', 'descriptor_name': 'Caffeine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008657', 'descriptor_name': 'Metabolic Clearance Rate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008657', 'descriptor_name': 'Metabolic Clearance Rate', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008730', 'descriptor_name': 'Methoxsalen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011701', 'descriptor_name': 'PUVA Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011565', 'descriptor_name': 'Psoriasis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011565', 'descriptor_name': 'Psoriasis', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/clpt.1987.209', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S159852663', 'display_name': 'Clinical Pharmacology & Therapeutics', 'issn_l': '0009-9236', 'issn': ['0009-9236', '1085-8733', '1532-6535'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/3690940', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.77}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4387644765', 'https://openalex.org/W2091276981', 'https://openalex.org/W2068997830', 'https://openalex.org/W2056938528', 'https://openalex.org/W2041051947', 'https://openalex.org/W2020458168', 'https://openalex.org/W2020059354', 'https://openalex.org/W2009291044', 'https://openalex.org/W2006760364', 'https://openalex.org/W1992051646'], 'abstract_inverted_index': {'The': [0, 65, 115], 'acute': [1], 'effect': [2], 'of': [3, 8, 13, 49, 57, 61, 67, 93, 100, 113, 118, 128, 145, 153, 160, 182, 193, 205, 207, 220], 'a': [4, 45, 142], 'single': [5, 46], 'oral': [6, 47, 59], 'dose': [7, 48, 60], 'methoxsalen': [9, 52, 176, 197, 208], 'on': [10], 'the': [11, 80, 91, 96, 121, 125, 158, 178], 'pharmacokinetics': [12], 'caffeine': [14, 68, 101, 119, 129, 146], 'was': [15, 27, 43], 'investigated': [16], 'in': [17, 79, 148, 167, 185, 213, 216], 'five': [18], 'nonsmoking': [19], 'volunteers': [20], 'with': [21, 36, 135, 150, 173, 200], 'psoriasis.': [22, 151], 'Caffeine,': [23], '200': [24, 62], 'mg': [25, 63], 'orally,': [26], 'administered': [28, 139, 162], 'to': [29, 83, 108, 123, 209], 'each': [30, 41], 'subject': [31, 42], 'at': [32, 106], 'baseline': [33, 107], 'before': [34, 55], 'treatment': [35], 'methoxsalen.': [37, 89, 114, 136, 170], 'One': [38], 'week': [39], 'later': [40], 'given': [44], '1.2': [50], 'mg/kg': [51], '1': [53], 'hour': [54], 'administration': [56, 112], 'another': [58], 'caffeine.': [64], 'clearance': [66], 'declined': [69], 'markedly': [70], 'from': [71, 103], '110': [72], '±': [73, 77, 85], '17': [74], 'ml/min': [75, 87], '(mean': [76], 'SE)': [78], 'control': [81], 'study': [82], '34': [84], '5': [86], 'after': [88, 111], 'During': [90], 'period': [92], 'maximum': [94], 'inhibition': [95, 192], 'mean': [97], 'elimination': [98, 159], 'half-life': [99], 'increased': [102], '5.6': [104], 'hours': [105, 110], '57': [109], 'peak': [116, 126], 'concentration': [117, 127], 'and': [120, 215, 218, 225], 'time': [122], 'reach': [124], 'were': [130], 'not': [131], 'affected': [132], 'by': [133, 196], 'pretreatment': [134], 'Thus,': [137], 'methoxsalen,': [138], 'acutely,': [140], 'is': [141, 177, 198], 'potent': [143, 180], 'inhibitor': [144, 181], 'metabolism': [147, 184, 195], 'humans': [149], 'Results': [152], 'this': [154], 'investigation': [155], 'suggest': [156], 'that': [157, 191], 'concurrently': [161], 'drugs': [163], 'may': [164], 'be': [165], 'inhibited': [166], 'patients': [168], 'receiving': [169], 'In': [171], 'comparison': [172], 'other': [174], 'drugs,': [175], 'most': [179], 'drug': [183, 194], 'humans.': [186], 'Other': [187], 'work': [188], 'has': [189], 'shown': [190], 'associated': [199], 'both': [201], 'extensive': [202], 'covalent': [203], 'binding': [204], 'metabolite(s)': [206], 'liver': [210], 'microsomal': [211], 'protein': [212], 'vitro': [214], 'vivo': [217], 'inactivation': [219], 'cytochrome': [221], 'P-450.': [222], 'Clinical': [223], 'Pharmacology': [224], 'Therapeutics': [226], '(1987)': [227], '42,': [228], '621–626;': [229], 'doi:10.1038/clpt.1987.209': [230]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2090356052', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 4}], 'updated_date': '2024-12-10T22:22:42.855185', 'created_date': '2016-06-24'}